{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:42:30Z","timestamp":1775011350805,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ygeno.2024.110930","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:33:09Z","timestamp":1724826789000},"page":"110930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Whole transcriptome sequencing indicated the Anti-tumor immunity of NLRP3 in breast cancer"],"prefix":"10.1016","volume":"116","author":[{"given":"Da","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoshen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygeno.2024.110930_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"issue":"11","key":"10.1016\/j.ygeno.2024.110930_bb0015","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"issue":"6468","key":"10.1016\/j.ygeno.2024.110930_bb0020","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.aav2588","article-title":"Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion","volume":"366","author":"Leone","year":"2019","journal-title":"Science"},{"issue":"31","key":"10.1016\/j.ygeno.2024.110930_bb0025","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/onc.2017.65","article-title":"Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1","volume":"36","author":"Cohen","year":"2017","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.ygeno.2024.110930_bb0030","doi-asserted-by":"crossref","first-page":"9136","DOI":"10.1002\/jcp.26847","article-title":"Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity","volume":"233","author":"Hong","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.ygeno.2024.110930_bb0035","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.it.2021.11.009","article-title":"Inflammatory and immune effects on tumor progression","volume":"43","author":"Mehla","year":"2022","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.ygeno.2024.110930_bb0045","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1158\/0008-5472.CAN-22-1427","article-title":"Lipid-associated macrophages are induced by Cancer-associated fibroblasts and mediate immune suppression in breast Cancer","volume":"82","author":"Timperi","year":"2022","journal-title":"Cancer Res."},{"issue":"6284","key":"10.1016\/j.ygeno.2024.110930_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ygeno.2024.110930_bb0055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1158\/2326-6066.CIR-16-0269","article-title":"Inflammasomes and Cancer","volume":"5","author":"Karki","year":"2017","journal-title":"Cancer Immunol. Res."},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"Regulation of inflammasome activation","volume":"265","author":"Man","year":"2015","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nm.2999","article-title":"Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth","volume":"19","author":"Bruchard","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0070","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pharmthera.2014.02.002","article-title":"Inflammasome: cancer's friend or foe?","volume":"143","author":"Terlizzi","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.ygeno.2024.110930_bb0075","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181709","article-title":"NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer","volume":"39","author":"Velloso","year":"2019","journal-title":"Biosci. Rep."},{"issue":"18","key":"10.1016\/j.ygeno.2024.110930_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814254","article-title":"Thymoquinone, a novel multi-strike inhibitor of pro-tumorigenic breast Cancer (BC) markers: CALR, NLRP3 pathway and sPD-L1 in PBMCs of HR+ and TNBC patients","volume":"24","author":"Elgohary","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0085","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.bbrc.2017.06.117","article-title":"IL-1beta induced methylation of the estrogen receptor ERalpha gene correlates with EMT and chemoresistance in breast cancer cells","volume":"490","author":"Jimenez-Garduno","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2024.110930_bb0090","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2023.14","article-title":"Inflammasomes in breast cancer: the ignition spark of progression and resistance?","volume":"25","author":"Elgohary","year":"2023","journal-title":"Expert Rev. Mol. Med."},{"issue":"8","key":"10.1016\/j.ygeno.2024.110930_bb0095","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1080\/15548627.2016.1183081","article-title":"SESN2\/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages","volume":"12","author":"Kim","year":"2016","journal-title":"Autophagy"},{"issue":"7329","key":"10.1016\/j.ygeno.2024.110930_bb0100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13045-020-00936-9","article-title":"Crosstalks between inflammasome and autophagy in cancer","volume":"13","author":"Chung","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.ygeno.2024.110930_bb0110","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1084\/jem.20160392","article-title":"S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3\/IL-1beta","volume":"214","author":"Weichand","year":"2017","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.ygeno.2024.110930_bb0115","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1069938","article-title":"Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: a large-scale meta-analysis","volume":"5","author":"Garg","year":"2016","journal-title":"Oncoimmunology"},{"issue":"15","key":"10.1016\/j.ygeno.2024.110930_bb0120","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.ygeno.2024.110930_bb0125","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"18","key":"10.1016\/j.ygeno.2024.110930_bb0130","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0135","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov. (Camb)"},{"key":"10.1016\/j.ygeno.2024.110930_bb0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"issue":"10","key":"10.1016\/j.ygeno.2024.110930_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/psp.2013.56","article-title":"Application of ggplot2 to Pharmacometric graphics","volume":"2","author":"Ito","year":"2013","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.ygeno.2024.110930_bb0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinform."},{"issue":"49","key":"10.1016\/j.ygeno.2024.110930_bb0155","doi-asserted-by":"crossref","first-page":"12994","DOI":"10.1073\/pnas.1705165114","article-title":"Cancer cells induce interleukin-22 production from memory CD4(+) T cells via interleukin-1 to promote tumor growth","volume":"114","author":"Voigt","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.ygeno.2024.110930_bb0160","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1073\/pnas.1812266115","article-title":"Blocking IL-1beta reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation","volume":"116","author":"Kaplanov","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0165","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/acsnano.0c00962","article-title":"Cell-penetrating nanoparticles activate the Inflammasome to enhance antibody production by targeting microtubule-associated protein 1-light chain 3 for degradation","volume":"14","author":"Zhu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.ygeno.2024.110930_bb0170","doi-asserted-by":"crossref","first-page":"1104753","DOI":"10.3389\/fimmu.2023.1104753","article-title":"Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME)","volume":"14","author":"Reid","year":"2023","journal-title":"Front. Immunol."},{"issue":"7081","key":"10.1016\/j.ygeno.2024.110930_bb0175","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ygeno.2024.110930_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121756","article-title":"EIF4G1 is a potential prognostic biomarker of breast Cancer","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0185","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1038\/s41467-019-12370-8","article-title":"NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis","volume":"10","author":"Ershaid","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0190","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1158\/2326-6066.CIR-21-1073","article-title":"Tumor-associated CD19+CD39- B regulatory cells deregulate class-switch recombination to suppress antibody responses","volume":"11","author":"Pati","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"9","key":"10.1016\/j.ygeno.2024.110930_bb0195","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.18632\/aging.204081","article-title":"CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database","volume":"14","author":"Wang","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.ygeno.2024.110930_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005869","article-title":"CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer","volume":"16","author":"Chen","year":"2018","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.ygeno.2024.110930_bb0205","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-023-01337-3","article-title":"PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ygeno.2024.110930_bb0210","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12943-015-0306-4","article-title":"The role of CCL21\/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis","volume":"14","author":"Tutunea-Fatan","year":"2015","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.ygeno.2024.110930_bb0215","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s10528-021-10029-y","article-title":"Impact of genetic variants in IL-2RA and IL-2RB on breast cancer risk in Chinese Han women","volume":"59","author":"He","year":"2021","journal-title":"Biochem. Genet."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:59:34Z","timestamp":1728370774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754324001514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0888754324001514"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110930","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole transcriptome sequencing indicated the Anti-tumor immunity of NLRP3 in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110930"}}