{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:05:53Z","timestamp":1793502353611,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013211","name":"Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ygeno.2024.110945","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:51:19Z","timestamp":1727398279000},"page":"110945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The molecular regulated mechanism of METTL3 and FTO in lipid metabolism of Hu sheep"],"prefix":"10.1016","volume":"116","author":[{"given":"Bowen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengkui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2024.110945_bb0005","first-page":"2430","article-title":"Variation in volatile flavor compounds of cooked mutton meatballs during storage","volume":"10","author":"Zhang","year":"2021","journal-title":"Foods (Basel, Switzerland)"},{"key":"10.1016\/j.ygeno.2024.110945_bb0010","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41586-020-03135-1","article-title":"m6A RNA methylation regulates the fate of endogenous retroviruses","volume":"591","author":"Chelmicki","year":"2021","journal-title":"Nat"},{"key":"10.1016\/j.ygeno.2024.110945_bb0015","first-page":"1635","article-title":"Cooper, comprehensive analysis of mrna methylation reveals enrichment in 3\u2032 utrs and near stop codons meyer et al cell","volume":"149","author":"Bhatnagar","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2024.110945_bb0020","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1097\/CM9.0000000000001528","article-title":"Development and validation of m6A RNA methylation regulators-based signature in lung adenocarcinoma","volume":"134","author":"Guo","year":"2021","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ygeno.2024.110945_bb0025","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105977","article-title":"m6A RNA methylation: from mechanisms to therapeutic potential","volume":"40","author":"He","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.ygeno.2024.110945_bb0030","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-024-05293-6","article-title":"The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases","volume":"22","author":"Wu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ygeno.2024.110945_bb0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A readers, writers, and erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12943-023-01782-2","article-title":"The role of m6A methylation in therapy resistance in cancer","volume":"22","author":"Zhuang","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ygeno.2024.110945_bb0045","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1111\/jcmm.13491","article-title":"METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells","volume":"22","author":"Feng","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ygeno.2024.110945_bb0050","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/iub.1974","article-title":"Loss of m6 a on FAM134B promotes adipogenesis in porcine adipocytes through m6 A-YTHDF2-dependent way","volume":"71","author":"Min","year":"2019","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ygeno.2024.110945_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102793","article-title":"RNA N6-methyladenosine profiling reveals differentially methylated genes associated with intramuscular fat metabolism during breast muscle development in chicken","volume":"102","author":"Yu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ygeno.2024.110945_bb0060","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.ygeno.2024.110945_bb0065","doi-asserted-by":"crossref","DOI":"10.1111\/obr.12942","article-title":"Emerging role of m6A RNA methylation in nutritional physiology and metabolism","volume":"21","author":"Wu","year":"2020","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ygeno.2024.110945_bb0070","doi-asserted-by":"crossref","first-page":"41606","DOI":"10.1038\/srep41606","article-title":"AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2024.110945_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12915-022-01239-w","article-title":"DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO\/m6A\/DDIT4\/PGC1\u03b1 signaling","volume":"20","author":"Chen","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2015.02.048","article-title":"MRNA m6A methylation downregulates adipogenesis in porcine adipocytes","volume":"459","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2024.110945_bb0085","first-page":"567","article-title":"Mettl3 deficiency sustains long-chain fatty acid absorption through suppressing Traf6-dependent inflammation response","volume":"202","author":"Xin","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0090","doi-asserted-by":"crossref","first-page":"e00116","DOI":"10.1128\/MCB.00116-18","article-title":"The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in Adipogenesis","volume":"38","author":"Kobayashi","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0095","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1002\/jcb.26746","article-title":"FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation","volume":"119","author":"Kang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ygeno.2024.110945_bb0100","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.3390\/ijms241511926","article-title":"Molecular mechanism of m6A methylation modification genes METTL3 and FTO in regulating heat stress in sheep","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ygeno.2024.110945_bb0105","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.3390\/cimb44080248","article-title":"Development of an improved method for the isolation and culture of newborn sheep primary hepatocytes","volume":"44","author":"Chen","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0110","first-page":"i884","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinf"},{"key":"10.1016\/j.ygeno.2024.110945_bb0115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ygeno.2024.110945_bb0120","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0125","first-page":"166","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinf"},{"key":"10.1016\/j.ygeno.2024.110945_bb0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0135","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1021\/acsbiomaterials.8b00652","article-title":"Establishment of an ex vivo model of nonalcoholic fatty liver disease using a tissue-engineered liver","volume":"4","author":"Wu","year":"2018","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.ygeno.2024.110945_bb0140","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cbi.2006.11.004","article-title":"A human hepatocellular in vitro model to investigate steatosis","volume":"165","author":"G\u00f3mez-Lech\u00f3n","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ygeno.2024.110945_bb0145","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.3390\/molecules28062570","article-title":"Nobiletin intake attenuates hepatic lipid profiling and oxidative stress in HFD-induced nonalcoholic-fatty-liver-disease mice","volume":"28","author":"Ke","year":"2023","journal-title":"Mol"},{"key":"10.1016\/j.ygeno.2024.110945_bb0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13098-021-00647-2","article-title":"Diet-induced obesity in animal models: points to consider and influence on metabolic markers","volume":"13","author":"de Moura","year":"2021","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ygeno.2024.110945_bb0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phymed.2018.07.008","article-title":"Lycopus iucidus turcz. Ex benth. Attenuates free fatty acid-induced steatosis in HepG2 cells and non-alcoholic fatty liver disease in high-fat diet-induced obese mice","volume":"55","author":"Lee","year":"2019","journal-title":"Phytomed"},{"key":"10.1016\/j.ygeno.2024.110945_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jmf.2018.4186","article-title":"Strontium alleviates endoplasmic reticulum stress in a nonalcoholic fatty liver disease model","volume":"21","author":"Jiang","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ygeno.2024.110945_bb0165","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1186\/s12864-018-5175-y","article-title":"RNA-seq of muscle from pigs divergent in feed efficiency and product quality identifies differences in immune response, growth, and macronutrient and connective tissue metabolism","volume":"19","author":"Horodyska","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygeno.2024.110945_bb0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12864-019-5460-4","article-title":"RNA-sequencing analysis of shell gland shows differences in gene expression profile at two time-points of eggshell formation in laying chickens","volume":"20","author":"Khan","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygeno.2024.110945_bb0175","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s12859-018-2553-z","article-title":"Gene co-expression networks from RNA sequencing of dairy cattle identifies genes and pathways affecting feed efficiency","volume":"19","author":"Salleh","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ygeno.2024.110945_bb0180","first-page":"1600","article-title":"Fat mass and obesity associated (FTO) gene and hepatic glucose and lipid metabolism","volume":"10","author":"Mizuno","year":"2018","journal-title":"Nutr"},{"key":"10.1016\/j.ygeno.2024.110945_bb0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ygeno.2024.110945_bb0190","series-title":"Syndr","first-page":"4843","article-title":"Regulation of methylase METTL3 on fat deposition, diabetes, Metab","volume":"vol. 14","author":"Luo","year":"2021"},{"key":"10.1016\/j.ygeno.2024.110945_bb0195","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Sci"},{"key":"10.1016\/j.ygeno.2024.110945_bb0200","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052348","article-title":"m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation","volume":"22","author":"Wu","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ygeno.2024.110945_bb0205","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41417-021-00406-5","article-title":"METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression","volume":"29","author":"Chen","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ygeno.2024.110945_bb0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fnut.2018.00061","article-title":"Betaine and choline improve lipid homeostasis in obesity by participation in mitochondrial oxidative demethylation","volume":"5","author":"Sivanesan","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ygeno.2024.110945_bb0215","first-page":"881","article-title":"Betaine supplementation causes an increase in fatty acid oxidation and carbohydrate metabolism in livers of mice fed a high-fat diet: a proteomic analysis","volume":"11","author":"Fan","year":"2022","journal-title":"Foods (Basel, Switzerland)"},{"key":"10.1016\/j.ygeno.2024.110945_bb0220","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/jpn.13633","article-title":"Mechanism of action and the uses betaine in pig production","volume":"106","author":"Fu","year":"2022","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.ygeno.2024.110945_bb0225","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.jnutbio.2015.08.014","article-title":"The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase \u03b11 subunit","volume":"26","author":"Zhou","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ygeno.2024.110945_bb0230","doi-asserted-by":"crossref","DOI":"10.1111\/obr.12942","article-title":"Emerging role of m6 a RNA methylation in nutritional physiology and metabolism","volume":"21","author":"Wu","year":"2020","journal-title":"Obes. Rev."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:09:17Z","timestamp":1733357357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754324001666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0888754324001666"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110945","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The molecular regulated mechanism of METTL3 and FTO in lipid metabolism of Hu sheep","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110945"}}