{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:56:54Z","timestamp":1777874214185,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ygeno.2026.111217","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T22:53:53Z","timestamp":1770591233000},"page":"111217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic and metabolic signatures in systemic lupus erythematous: The impact of excess body weight on adipose tissue DNA methylation profile"],"prefix":"10.1016","volume":"118","author":[{"given":"Lucas M.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhulia Caroline N.L.","family":"da Mota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia L.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael B.","family":"Sposeto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela A.S.","family":"Pinhel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla B.","family":"Nonino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Costa-Fraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Belen","family":"Crujeiras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Gonzales","family":"Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Diaz-Lagares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidossessi W.","family":"Hounkpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Borba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Gualano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina F.","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2026.111217_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102374","article-title":"Inflammatory markers in systemic lupus erythematosus","volume":"110","author":"Aringer","year":"2020","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard-2022-223035","article-title":"Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study","volume":"82","author":"Tian","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ygeno.2026.111217_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102359","article-title":"The pathogenesis of systemic lupus erythematosus: harnessing big data to understand the molecular basis of lupus","volume":"110","author":"Catalina","year":"2020","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0020","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41590-020-0677-6","article-title":"Autoimmunity and organ damage in systemic lupus erythematosus","volume":"21","author":"Tsokos","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ygeno.2026.111217_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","article-title":"Systemic lupus erythematosus: diagnosis and clinical management","volume":"96","author":"Fava","year":"2019","journal-title":"J. Autoimmun."},{"issue":"12","key":"10.1016\/j.ygeno.2026.111217_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102693","article-title":"Childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome: a multicenter study with 1519 patients","volume":"19","author":"Islab\u00e3o","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ygeno.2026.111217_bb0035","first-page":"8","article-title":"Risk of systemic lupus erythematosus in patients with anti-phospholipid syndrome: a population-based study","author":"Chen","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0040","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12882-020-01868-9","article-title":"Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study","volume":"21","author":"Katsuyama","year":"2020","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.ygeno.2026.111217_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100291","article-title":"Adults with systemic lupus exhibit distinct molecular phenotypes in a cross-sectional study","volume":"20","author":"Guthridge","year":"2020","journal-title":"EClinicalMedicine"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0050","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12882-024-03882-7","article-title":"Prevalence and risk factors of osteoporosis in lupus nephritis patients in China: a cross-sectional study","volume":"25","author":"Hong","year":"2024","journal-title":"BMC Nephrol."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3899\/jrheum.200435","article-title":"Higher prevalence and degree of insulin resistance in patients with rheumatoid arthritis than in patients with systemic lupus erythematosus","volume":"48","author":"Quevedo-Abeledo","year":"2021","journal-title":"J. Rheumatol."},{"issue":"5","key":"10.1016\/j.ygeno.2026.111217_bb0060","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3899\/jrheum.210087","article-title":"Gestational diabetes mellitus risk in pregnant women with systemic lupus erythematosus","volume":"49","author":"Gernaat","year":"2022","journal-title":"J. Rheumatol."},{"issue":"10","key":"10.1016\/j.ygeno.2026.111217_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102371","article-title":"Systemic lupus erythematosus and hypertension","volume":"18","author":"Munguia-Realpozo","year":"2019","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0070","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/rheumatology\/keaa453","article-title":"Impact of overweight and obesity on patient-reported health-related quality of life in systemic lupus erythematosus","volume":"60","author":"Gomez","year":"2021","journal-title":"Rheumatology"},{"issue":"7","key":"10.1016\/j.ygeno.2026.111217_bb0075","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/09612033211006790","article-title":"Prevalence and treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus: a multi-Centre cross-sectional study","volume":"30","author":"Saito","year":"2021","journal-title":"Lupus"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0080","first-page":"3","article-title":"Correlation between body mass index and disease activity in patients with systemic lupus erythematosus from China","volume":"66","author":"Li","year":"2025"},{"issue":"10","key":"10.1016\/j.ygeno.2026.111217_bb0085","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1007\/s10067-021-05731-6","article-title":"Metabolic syndrome and adipokine levels in systemic lupus erythematosus and systemic sclerosis","volume":"40","author":"Gigante","year":"2021","journal-title":"Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0090","doi-asserted-by":"crossref","DOI":"10.12669\/pjms.36.6.2093","article-title":"Metabolic syndrome in systemic lupus erythematosus was closely related to body mass index, blood pressure, blood sugar, blood lipids, and arthritis","volume":"36","author":"Jin","year":"2020","journal-title":"Pak. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0095","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1756-185X.2011.01698.x","article-title":"The impact of obesity in systemic lupus erythematosus on disease parameters, quality of life, functional capacity and the risk of atherosclerosis","volume":"15","author":"Rizk","year":"2012","journal-title":"Int. J. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111217_bb0100","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/nu13020504","article-title":"The impact of obesity and a high-fat diet on clinical and immunological features in systemic lupus erythematosus","volume":"13","author":"Kono","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/rheumatology\/keaa210","article-title":"Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study","volume":"60","author":"Pocovi-Gerardino","year":"2021","journal-title":"Rheumatology"},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287753","article-title":"Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: a systematic review and meta-analysis protocol","volume":"18","author":"de Medeiros","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2026.111217_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108637","article-title":"Association of cardiometabolic risk status with clinical activity and damage in systemic lupus erythematosus patients: a cross-sectional study","volume":"222","author":"Campos-L\u00f3pez","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ygeno.2026.111217_bb0120","first-page":"8","article-title":"The interplay between adipose tissue and vasculature: role of oxidative stress in obesity","author":"Zhou","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0125","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000436","article-title":"Associations of metabolic syndrome in SLE","volume":"7","author":"Apostolopoulos","year":"2020","journal-title":"Lupus Sci. Med."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0130","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/0961203320913616","article-title":"Obesity increases the incidence of new-onset lupus nephritis and organ damage during follow-up in patients with systemic lupus erythematosus","volume":"29","author":"Kang","year":"2020","journal-title":"Lupus"},{"issue":"4","key":"10.1016\/j.ygeno.2026.111217_bb0135","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3988\/jcn.2020.16.4.605","article-title":"Causes, risk factors, and clinical outcomes of stroke in Korean young adults: systemic lupus erythematosus is associated with unfavorable outcomes","volume":"16","author":"Kwon","year":"2020","journal-title":"J. Clin. Neurol."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0140","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/medicina59061033","article-title":"Disentangling the pathogenesis of systemic lupus erythematosus: close ties between immunological, genetic and environmental factors","volume":"59","author":"Sutanto","year":"2023","journal-title":"Medicina (B Aires)"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0145","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/08916934.2020.1722108","article-title":"DNA methylation changes on immune cells in systemic lupus erythematosus","volume":"53","author":"Hurtado","year":"2020","journal-title":"Autoimmunity"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/09612033221148099","article-title":"DNA methylation alterations in systemic lupus erythematosus: a systematic review of case-control studies","volume":"32","author":"Ehtesham","year":"2023","journal-title":"Lupus"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13072-017-0130-8","article-title":"DNA methylation and DNA methyltransferases","volume":"10","author":"Edwards","year":"2017","journal-title":"Epigenetics Chromatin"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111217_bb0160","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2017-212379","article-title":"DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus","volume":"77","author":"Imgenberg-Kreuz","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ygeno.2026.111217_bb0165","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaut.2018.09.007","article-title":"Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI","volume":"96","author":"Joseph","year":"2019","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0170","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-4632.2010.04804.x","article-title":"Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus","volume":"50","author":"Zhu","year":"2011","journal-title":"Int. J. Dermatol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0175","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13148-024-01699-7","article-title":"DNA methylation and whole-genome transcription analysis in CD4+ T cells from systemic lupus erythematosus patients with or without renal damage","volume":"16","author":"Liu","year":"2024","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41525-024-00420-0","article-title":"Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants","volume":"9","author":"Castellini-P\u00e9rez","year":"2024","journal-title":"NPJ Genom. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0185","doi-asserted-by":"crossref","DOI":"10.1111\/exd.14986","article-title":"Epigenetic mechanisms driving the pathogenesis of systemic lupus erythematosus, systemic sclerosis and dermatomyositis","volume":"33","author":"Zhang","year":"2024","journal-title":"Exp. Dermatol."},{"issue":"5\u20136","key":"10.1016\/j.ygeno.2026.111217_bb0190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00011-022-01554-6","article-title":"Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus","volume":"71","author":"Bolouri","year":"2022","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/15592294.2021.1876285","article-title":"DNA methylation profile of genes involved in inflammation and autoimmunity correlates with vascular function in morbidly obese adults","volume":"17","author":"Ali","year":"2022","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0200","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12881-018-0542-8","article-title":"Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes","volume":"19","author":"Barajas-Olmos","year":"2018","journal-title":"BMC Med. Genet."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0205","first-page":"31","article-title":"Diet, DNA methylation and systemic lupus erythematosus: evidence and perspectives focused on personalized nutrition","volume":"17","author":"Ribeiro","year":"2024","journal-title":"Lifestyle Genomics"},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0210","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.18632\/aging.101882","article-title":"DNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications","volume":"11","author":"Salas-P\u00e9rez","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.ygeno.2026.111217_bb0215","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.semcdb.2022.09.008","article-title":"Epigenetic regulation of inflammation: the metabolomics connection","volume":"154","author":"Rath","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0220","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/21623945.2021.1978157","article-title":"Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes","volume":"10","author":"Mirzaeicheshmeh","year":"2021","journal-title":"Adipocyte"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0225","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1038\/s41467-022-29792-6","article-title":"DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases","volume":"13","author":"Wielscher","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.ygeno.2026.111217_bb0230","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.17219\/acem\/110321","article-title":"Obesity-induced insulin resistance via changes in the DNA methylation profile of insulin pathway genes","volume":"28","author":"Ma\u0142odobra-Mazur","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0235","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1515\/biol-2018-0024","article-title":"Aberrant DNA methylation involved in obese women with systemic insulin resistance","volume":"13","author":"Zhang","year":"2018","journal-title":"Open Life Sci."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevEukaryotGeneExpr.2018024760","article-title":"Epigenetic modification related to acetylation of histone and methylation of DNA as a key player in immunological disorders","volume":"29","author":"Qadir","year":"2019","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111217_bb0245","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2024-001279","article-title":"Methyl-donor supplementation in women with systemic lupus erythematosus with different nutritional status: the protocol for a randomised, double-blind, placebo-controlled trial","volume":"11","author":"da Mota","year":"2024","journal-title":"Lupus Sci. Med."},{"issue":"9","key":"10.1016\/j.ygeno.2026.111217_bb0250","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/art.40930","article-title":"2019 European league against rheumatism\/American College of Rheumatology Classification Criteria for systemic lupus erythematosus","volume":"71","author":"Aringer","year":"2019","journal-title":"Arthritis Rheum."},{"issue":"10","key":"10.1016\/j.ygeno.2026.111217_bb0255","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111217_bb0260","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0265","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s12864-021-07801-0","article-title":"Validation of reference genes for whole blood gene expression analysis in cord blood of preterm and full-term neonates and peripheral blood of healthy adults","volume":"22","author":"Hieronymus","year":"2021","journal-title":"BMC Genomics"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0270","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/physiolgenomics.00025.2005","article-title":"GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues","volume":"21","author":"Barber","year":"2005","journal-title":"Physiol. Genomics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0275","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0954422421000287","article-title":"Epigenetic linkage of systemic lupus erythematosus and nutrition","volume":"36","author":"Montoya","year":"2023","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.ygeno.2026.111217_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01686","article-title":"Shared and unique patterns of DNA methylation in systemic lupus erythematosus and primary Sj\u00f6gren\u2019s syndrome","volume":"10","author":"Imgenberg-Kreuz","year":"2019","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111217_bb0285","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3390\/nu17061086","article-title":"Genome-wide impact of folic acid on DNA methylation and gene expression in lupus adipocytes: an in vitro study on obesity","volume":"17","author":"Souza","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.ygeno.2026.111217_bb0290","first-page":"15","article-title":"An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus","author":"Zhou","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ygeno.2026.111217_bb0295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13148-025-02041-5","article-title":"Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial","volume":"18","author":"da Mota","year":"2026","journal-title":"Clin. Epigenetics."},{"issue":"7635","key":"10.1016\/j.ygeno.2026.111217_bb0300","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature20784","article-title":"Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity","volume":"541","author":"Wahl","year":"2017","journal-title":"Nature"},{"issue":"8042","key":"10.1016\/j.ygeno.2026.111217_bb0305","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-024-08165-7","article-title":"Adipose tissue retains an epigenetic memory of obesity after weight loss","volume":"636","author":"Hinte","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2026.111217_bb0310","first-page":"12","article-title":"DNA methylation sustains \u201cinflamed\u201d memory of peripheral immune cells aggravating kidney inflammatory response in chronic kidney disease","author":"Chen","year":"2021","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.ygeno.2026.111217_bb0315","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.3390\/cimb46070441","article-title":"Epigenetic and molecular alterations in obesity: linking CRP and DNA methylation to systemic inflammation","volume":"46","author":"Cucoreanu","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"7","key":"10.1016\/j.ygeno.2026.111217_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070982","article-title":"Epigenetic reprogramming of the inflammatory response in obesity and type 2 diabetes","volume":"12","author":"Zatterale","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111217_bb0325","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/07853890.2013.857259","article-title":"DNA methylation in obesity and type 2 diabetes","volume":"46","author":"de Mello","year":"2014","journal-title":"Ann. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0330","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1038\/s41598-022-12325-y","article-title":"Effect of excess weight and insulin resistance on DNA methylation in prepubertal children","volume":"12","author":"Barbosa","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111217_bb0335","doi-asserted-by":"crossref","first-page":"184","DOI":"10.12997\/jla.2021.10.2.184","article-title":"Immunologic aspects of dyslipidemia: a critical regulator of adaptive immunity and immune disorders","volume":"10","author":"Kim","year":"2021","journal-title":"J. Lipid Atheroscler."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0340","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s10020-020-00220-z","article-title":"DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia","volume":"26","author":"P\u0142atek","year":"2020","journal-title":"Mol. Med."},{"issue":"11","key":"10.1016\/j.ygeno.2026.111217_bb0345","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1093\/jimmun\/vkaf135","article-title":"Epigenetic and metabolic regulation of macrophage responsiveness and memory","volume":"214","author":"Daskalaki","year":"2025","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.ygeno.2026.111217_bb0350","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.3390\/genes14122207","article-title":"Epigenetic profiling of type 2 diabetes mellitus: an epigenome-wide association study of DNA methylation in the Korean genome and epidemiology study","volume":"14","author":"Seo","year":"2023","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/jcm8010087","article-title":"Altered adipose tissue DNA methylation status in metabolic syndrome: relationships between global DNA methylation and specific methylation at Adipogenic, lipid metabolism and inflammatory candidate genes and metabolic variables","volume":"8","author":"Castellano-Castillo","year":"2019","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0360","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13148-024-01679-x","article-title":"Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in east Asians","volume":"16","author":"Li","year":"2024","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0365","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13148-021-01162-x","article-title":"Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals","volume":"13","author":"Chen","year":"2021","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0370","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13148-024-01792-x","article-title":"Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes","volume":"16","author":"Horton","year":"2024","journal-title":"Clin. Epigenetics"},{"issue":"4","key":"10.1016\/j.ygeno.2026.111217_bb0375","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41366-024-01458-x","article-title":"Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain","volume":"48","author":"Opsahl","year":"2024","journal-title":"Int. J. Obes."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111217_bb0380","doi-asserted-by":"crossref","DOI":"10.1093\/exposome\/osad001","article-title":"Epigenetics and the exposome: DNA methylation as a proxy for health impacts of prenatal environmental exposures","volume":"3","author":"Colwell","year":"2023","journal-title":"Exposome"},{"issue":"14","key":"10.1016\/j.ygeno.2026.111217_bb0385","doi-asserted-by":"crossref","first-page":"14","DOI":"10.21037\/jlpm-25-4","article-title":"Impact of social stress on epigenetics: an updated narrative review","volume":"10","author":"Gabbianelli","year":"2025","journal-title":"J. Lab. Precis Med."},{"issue":"8","key":"10.1016\/j.ygeno.2026.111217_bb0390","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjae039","article-title":"Hypoxia signaling in the adipose tissue","volume":"16","author":"Huynh","year":"2025","journal-title":"J. Mol. Cell Biol."},{"issue":"18","key":"10.1016\/j.ygeno.2026.111217_bb0395","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.3390\/ijms25189802","article-title":"Hypoxia in human obesity: new insights from inflammation towards insulin resistance\u2014a narrative review","volume":"25","author":"Mirabelli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ygeno.2026.111217_bb0400","first-page":"12","article-title":"Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment","author":"Capatina","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1\u20133","key":"10.1016\/j.ygeno.2026.111217_bb0405","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/ars.2023.0397","article-title":"Activation of hypoxia inducible Factor-1 alpha-mediated DNA methylation enzymes (DNMT3a and TET2) under hypoxic conditions regulates S100A6 transcription to promote lung cancer cell growth and metastasis","volume":"41","author":"Wang","year":"2024","journal-title":"Antioxid. Redox Signal."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088875432600025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088875432600025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:19:34Z","timestamp":1777576774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088875432600025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S088875432600025X"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111217","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic and metabolic signatures in systemic lupus erythematous: The impact of excess body weight on adipose tissue DNA methylation profile","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111217"}}