{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:04:55Z","timestamp":1784045095511,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601015"],"award-info":[{"award-number":["31601015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["C2015201156"],"award-info":[{"award-number":["C2015201156"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ygeno.2026.111267","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:08:55Z","timestamp":1779811735000},"page":"111267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compartmentalized co-cultivation and temporal transcriptomics reveal SexM-mediated crosstalk between pheromone signaling and metabolic reprogramming in the industrial carotenoid producer Blakeslea trispora"],"prefix":"10.1016","volume":"118","author":[{"given":"Xin","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygeno.2026.111267_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11418-019-01364-x","article-title":"Carotenoids as natural functional pigments","volume":"74","author":"Maoka","year":"2020","journal-title":"J. Nat. Med."},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0120","article-title":"Natural carotenoids: recent advances on separation from microbial biomass and methods of analysis","volume":"12","author":"Papapostolou","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.ygeno.2026.111267_bb0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00253-004-1669-4","article-title":"Biotechnological lycopene production by mated fermentation of Blakeslea trispora","volume":"66","author":"Lopez-Nieto","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111267_bb0095","doi-asserted-by":"crossref","first-page":"28748","DOI":"10.1038\/s41598-025-13082-4","article-title":"Adaptive laboratory evolution of Blakeslea trispora under acetoacetanilide stress leads to enhanced beta-carotene biosynthesis","volume":"15","author":"Moradi","year":"2025","journal-title":"Sci. Rep."},{"issue":"25","key":"10.1016\/j.ygeno.2026.111267_bb0105","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1080\/10408398.2021.1908222","article-title":"Current developments on the application of microbial carotenoids as an alternative to synthetic pigments","volume":"62","author":"Mussagy","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"7175","key":"10.1016\/j.ygeno.2026.111267_bb0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature06453","article-title":"Identification of the sex genes in an early diverged fungus","volume":"451","author":"Idnurm","year":"2008","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ygeno.2026.111267_bb0090","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/AEM.69.7.4043-4048.2003","article-title":"Mutants and intersexual heterokaryons of Blakeslea trispora for production of beta-carotene and lycopene","volume":"69","author":"Mehta","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ygeno.2026.111267_bb0140","series-title":"Molecular aspects of sex and trisporoid signalling in mucoralean fungi","author":"Sahadevan","year":"2009"},{"issue":"15\u201316","key":"10.1016\/j.ygeno.2026.111267_bb0160","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.phytochem.2009.07.014","article-title":"Carotene derivatives in sexual communication of zygomycete fungi","volume":"70","author":"Schimek","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ygeno.2026.111267_bb0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0040-4020(01)99104-5","article-title":"The structure of trisporic C acid","volume":"22","author":"Caglioti","year":"1966","journal-title":"Tetrahedron Supplement"},{"key":"10.1016\/j.ygeno.2026.111267_bb0040","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0031-9422(00)85663-0","article-title":"Extraction of a sexual hormone from the mycelium of Mucor mucedo","volume":"7","author":"Gooday","year":"1968","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0010","first-page":"733","article-title":"Occurrence and chemical synthesis of apocarotenoids from mucorales: A review","volume":"12","author":"Barrero","year":"2017","journal-title":"Nat. Prod. Commun."},{"issue":"20","key":"10.1016\/j.ygeno.2026.111267_bb0020","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1039\/c1ob05712j","article-title":"New apocarotenoids and beta-carotene cleavage in Blakeslea trispora","volume":"9","author":"Barrero","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ygeno.2026.111267_bb0125","series-title":"Sexual Pheromones in the Fungi","first-page":"171","author":"Polaino SIdnurm","year":"2012"},{"issue":"11","key":"10.1016\/j.ygeno.2026.111267_bb0025","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.fgb.2007.07.008","article-title":"Cleavage of beta-carotene as the first step in sexual hormone synthesis in zygomycetes is mediated by a trisporic acid regulated beta-carotene oxygenase","volume":"44","author":"Burmester","year":"2007","journal-title":"Fungal Genet. Biol."},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0185","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.fgb.2012.03.002","article-title":"A gene for carotene cleavage required for pheromone biosynthesis and carotene regulation in the fungus Phycomyces blakesleeanus","volume":"49","author":"Tagua","year":"2012","journal-title":"Fungal Genet. Biol."},{"issue":"18","key":"10.1016\/j.ygeno.2026.111267_bb0155","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/cbic.200800477","article-title":"Cooperative biosynthesis of Trisporoids by the (+) and (\u2212) mating types of the zygomycete Blakeslea trispora","volume":"9","author":"Schachtschabel","year":"2008","journal-title":"Chembiochem"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0200","first-page":"570","article-title":"Trisporoids under the Stimulation of Carotenogenesis in Blakeslea trispora","volume":"81","author":"Vereshchagina","year":"2012","journal-title":"Mikrobiologiia"},{"issue":"2","key":"10.1016\/j.ygeno.2026.111267_bb0065","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0041-2017","article-title":"Fungal sex: The Mucoromycota","volume":"5","author":"Lee","year":"2017","journal-title":"Microbiol. Spectrum"},{"issue":"15","key":"10.1016\/j.ygeno.2026.111267_bb0130","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1039\/c2ob07147a","article-title":"Apocarotenoids in the sexual interaction of Phycomyces blakesleeanus","volume":"10","author":"Polaino","year":"2012","journal-title":"Org. Biomol. Chem."},{"issue":"23","key":"10.1016\/j.ygeno.2026.111267_bb0145","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1128\/AEM.02096-13","article-title":"Early and late trisporoids differentially regulate beta-carotene production and gene transcript Levels in the mucoralean fungi Blakeslea trispora and Mucor mucedo","volume":"79","author":"Sahadevan","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1134\/S0026261714050270","article-title":"Trisporoids and carotenogenesis in Blakeslea trispora","volume":"83","author":"Vereshchagina","year":"2014","journal-title":"Microbiology"},{"issue":"4","key":"10.1016\/j.ygeno.2026.111267_bb0170","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00253-005-1941-2","article-title":"Analysis of mating-dependent transcription of Blakeslea trispora carotenoid biosynthesis genes carB and carRA by quantitative real-time PCR","volume":"67","author":"Schmidt","year":"2005","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111267_bb0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00294-008-0206-x","article-title":"Genes involved in carotene synthesis and mating in Blakeslea trispora","volume":"54","author":"Kuzina","year":"2008","journal-title":"Curr. Genet."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111267_bb0205","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12934-022-01853-x","article-title":"SR5AL serves as a key regulatory gene in lycopene biosynthesis by Blakeslea trispora","volume":"21","author":"Wang","year":"2022","journal-title":"Microb. Cell Factories"},{"issue":"4","key":"10.1016\/j.ygeno.2026.111267_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/foods8040120","article-title":"Improved lycopene production from different substrates by mated fermentation of Blakeslea trispora","volume":"8","author":"Sevgili","year":"2019","journal-title":"Foods"},{"key":"10.1016\/j.ygeno.2026.111267_bb0165","series-title":"Microbial Carotenoids From Fungi: Methods and Protocols","first-page":"61","article-title":"Biosynthesis, extraction, purification, and analysis of trisporoid sexual communication compounds from mated cultures of Blakeslea trispora","author":"Schimek","year":"2012"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111267_bb0085","doi-asserted-by":"crossref","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads.pdf","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111267_bb0050","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.ygeno.2026.111267_bb0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.ygeno.2026.111267_bb0075","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2026.111267_bb0005","author":"Alexa"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0215","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"11","key":"10.1016\/j.ygeno.2026.111267_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: A free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2026.111267_bib216","author":"Zhang"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111267_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.228","article-title":"OmicShare tools: A zero-code interactive online platform for biological data analysis and visualization","volume":"3","author":"Mu","year":"2024","journal-title":"Imeta"},{"issue":"7","key":"10.1016\/j.ygeno.2026.111267_bb0055","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1128\/AEM.02845-05","article-title":"Modification of sexual development and carotene production by acetate and other small carboxylic acids in Blakeslea trispora and Phycomyces blakesleeanus","volume":"72","author":"Kuzina","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"issue":"Pt 4","key":"10.1016\/j.ygeno.2026.111267_bb0210","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1099\/mic.0.054106-0","article-title":"The mating-related loci sexM and sexP of the zygomycetous fungus Mucor mucedo and their transcriptional regulation by trisporoid pheromones","volume":"158","author":"Wetzel","year":"2012","journal-title":"Microbiology (Reading)"},{"issue":"4","key":"10.1016\/j.ygeno.2026.111267_bb0135","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1365-2958.2006.05293.x","article-title":"Regulation by blue light and heat shock of gene transcription in the fungus Phycomyces: proteins required for photoinduction and mechanism for adaptation to light","volume":"61","author":"Rodriguez-Romero","year":"2006","journal-title":"Mol. Microbiol."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111267_bb0035","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10123-021-00225-6","article-title":"Transcriptome sequencing and global analysis of blue light-responsive genes provide clues for high carotenoid yields in Blakeslea trispora","volume":"25","author":"Ge","year":"2022","journal-title":"Int. Microbiol."},{"issue":"22","key":"10.1016\/j.ygeno.2026.111267_bb0110","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1016\/j.cub.2020.08.051","article-title":"The DASH-type cryptochrome from the fungus Mucor circinelloides is a canonical CPD-photolyase","volume":"30","author":"Navarro","year":"2020","journal-title":"Curr. Biol."},{"issue":"49","key":"10.1016\/j.ygeno.2026.111267_bb0190","doi-asserted-by":"crossref","first-page":"15130","DOI":"10.1073\/pnas.1514637112","article-title":"Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution","volume":"112","author":"Tagua","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.ygeno.2026.111267_bb0150","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1073\/pnas.0900879106","article-title":"Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ygeno.2026.111267_bb0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fgb.2017.02.005","article-title":"The inhibition of mating in Phycomyces blakesleeanus by light is dependent on the MadA-MadB complex that acts in a sex-specific manner","volume":"101","author":"Shakya","year":"2017","journal-title":"Fungal Genet. Biol."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326000753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326000753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:20:28Z","timestamp":1784042428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754326000753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0888754326000753"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111267","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compartmentalized co-cultivation and temporal transcriptomics reveal SexM-mediated crosstalk between pheromone signaling and metabolic reprogramming in the industrial carotenoid producer Blakeslea trispora","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111267"}}