{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:43:51Z","timestamp":1785905031227,"version":"3.56.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82173459"],"award-info":[{"award-number":["82173459"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82473571"],"award-info":[{"award-number":["82473571"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["81872559"],"award-info":[{"award-number":["81872559"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["81972978"],"award-info":[{"award-number":["81972978"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ygeno.2026.111277","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:01:52Z","timestamp":1781312512000},"page":"111277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolocumab protects mice from radiation-induced damage by affecting hematopoietic cell lineage"],"prefix":"10.1016","volume":"118","author":[{"given":"Yuhan","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0005","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12964-024-01651-5","article-title":"Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury","volume":"22","author":"Liao","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"17","key":"10.1016\/j.ygeno.2026.111277_bb0010","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2009-10-248278","article-title":"Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose \u03b3-irradiation","volume":"115","author":"Yu","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41467-019-13853-4","article-title":"GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis","volume":"11","author":"Regan-Komito","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111277_bb0020","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1016\/S2352-3026(24)00077-2","article-title":"Immune effector cell-associated haematotoxicity after CAR T-cell therapy: from mechanism to management","volume":"11","author":"Rejeski","year":"2024","journal-title":"Lancet Haematol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0025","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41598-023-48248-5","article-title":"Exploring the mechanism of celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics","volume":"14","author":"Zeng","year":"2024","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.ygeno.2026.111277_bb0030","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2013.5635","article-title":"Hematopoietic stem cell injury induced by ionizing radiation","volume":"20","author":"Shao","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jcmm.13937","article-title":"Radioprotective effects of roxadustat (FG \u22124592) in haematopoietic system","volume":"23","author":"Zhang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ygeno.2026.111277_bb0040","article-title":"CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111277_bb0045","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/imm.13797","article-title":"FG-4592 protected haematopoietic system from ionising radiation in mice","volume":"172","author":"Wang","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.ygeno.2026.111277_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111614","article-title":"Scleroglucan protects the intestine from irradiation-induced injury by targeting the IL-17 signaling pathway","volume":"129","author":"Huang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111277_bb0055","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3892\/ijmm.2017.3047","article-title":"Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT\/sirtuin 1 pathway in mice","volume":"40","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ygeno.2026.111277_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156064","article-title":"PCSK9 in metabolism and diseases","volume":"163","author":"Ajoolabady","year":"2025","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111277_bb0065","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1210\/endrev\/bnab035","article-title":"The multifaceted biology of PCSK9","volume":"43","author":"Seidah","year":"2022","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ygeno.2026.111277_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108480","article-title":"Targeting PCSK9 to tackle cardiovascular disease","volume":"249","author":"Hummelgaard","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"16","key":"10.1016\/j.ygeno.2026.111277_bb0075","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa1500858","article-title":"Efficacy and safety of evolocumab in reducing lipids and cardiovascular events","volume":"372","author":"Sabatine","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111277_bb0080","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s13238-021-00821-2","article-title":"Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling","volume":"12","author":"Yuan","year":"2021","journal-title":"Protein Cell"},{"issue":"7","key":"10.1016\/j.ygeno.2026.111277_bb0085","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-011657","article-title":"Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8+ T cells","volume":"13","author":"Liu","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41392-023-01690-3","article-title":"Targeting proprotein convertase subtilisin\/kexin type 9 (PCSK9): from bench to bedside","volume":"9","author":"Bao","year":"2024","journal-title":"Sig. Transduct. Target Ther."},{"key":"10.1016\/j.ygeno.2026.111277_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108812","article-title":"Therapeutic PCSK9 targeting: inside versus outside the hepatocyte?","volume":"268","author":"Corsini","year":"2025","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111277_bb0100","first-page":"77","article-title":"Blood cell changes after radiation exposure as an indicator for hemopoietic stem cell function","volume":"3","author":"Fliedner","year":"1988","journal-title":"Bone Marrow Transplant."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111277_bb0105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rpd\/ncac033","article-title":"The influence of low-dose occupational radiation exposure on peripheral blood cells in a cohort of Chinese medical radiation workers","volume":"198","author":"Wang","year":"2022","journal-title":"Radiat. Prot. Dosimetry"},{"issue":"5","key":"10.1016\/j.ygeno.2026.111277_bb0110","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.exphem.2014.01.001","article-title":"Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors","volume":"42","author":"Dolence","year":"2014","journal-title":"Exp. Hematol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111277_bb0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.2021011570","article-title":"IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice","volume":"139","author":"Kovtonyuk","year":"2022","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ygeno.2026.111277_bb0120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1165\/rcmb.2010-0122OC","article-title":"Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression","volume":"44","author":"Mathew","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326000856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326000856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:45:31Z","timestamp":1785901531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754326000856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0888754326000856"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111277","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolocumab protects mice from radiation-induced damage by affecting hematopoietic cell lineage","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111277"}}