{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:26:33Z","timestamp":1793957193203,"version":"4.8.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530003"],"award-info":[{"award-number":["82530003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470056"],"award-info":[{"award-number":["82470056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","award":["2024YG001"],"award-info":[{"award-number":["2024YG001"]}],"id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016804","name":"Natural Science Foundation of Shenzhen Municipality","doi-asserted-by":"publisher","award":["20231120193941001"],"award-info":[{"award-number":["20231120193941001"]}],"id":[{"id":"10.13039\/100016804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ygeno.2026.111324","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:46:13Z","timestamp":1790095573000},"page":"111324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative profiling of multi-modal plasma cfRNA signatures enables detection and prognostic risk stratification in breast cancer"],"prefix":"10.1016","volume":"118","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ygeno.2026.111324_bb0005","first-page":"477","article-title":"Breast cancer statistics 2024","volume":"74","author":"Giaquinto","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.ygeno.2026.111324_bb0015","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.annonc.2024.07.726","article-title":"Tumour heterogeneity in molecular imaging for breast cancer","volume":"35","author":"Lobo-Martins","year":"2024","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111324_bb0020","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccell.2025.01.002","article-title":"Dynamics of molecular heterogeneity in high-risk luminal breast cancer\u2014from intrinsic to adaptive subtyping","volume":"43","author":"Denkert","year":"2025","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.56142","article-title":"Incidence rate trends of breast cancer overall and by molecular subtype by race and ethnicity and age","volume":"8","author":"Li","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0030","first-page":"1","article-title":"Molecular classification of hormone receptor-positive \/HER2-positive breast cancer reveals potential neoadjuvant therapeutic strategies","volume":"10","author":"Liu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jamaoncol.2024.5780","article-title":"Biomarker-directed radiotherapy in breast cancer: a narrative review","volume":"11","author":"Meattini","year":"2025","journal-title":"JAMA Oncol."},{"issue":"10","key":"10.1016\/j.ygeno.2026.111324_bb0040","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.annonc.2021.06.023","article-title":"Customizing local and systemic therapies for women with early breast cancer: the st. Gallen international consensus guidelines for treatment of early breast cancer 2021","volume":"32","author":"Burstein","year":"2021","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ygeno.2026.111324_bb0045","first-page":"1","article-title":"Global patterns and trends in breast cancer incidence and mortality across 185 countries","author":"Kim","year":"2025","journal-title":"Nat. Med."},{"issue":"8053","key":"10.1016\/j.ygeno.2026.111324_bb0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/d41586-025-00265-2","article-title":"Breast cancer is on the rise: data reveal drastic gap in survival rates","volume":"639","author":"Guglielmi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2026.111324_bb0055","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2025.0167","article-title":"Incidence and risk factors of interval and screen-detected breast cancer","author":"Zhang","year":"2025","journal-title":"JAMA Oncol."},{"issue":"11","key":"10.1016\/j.ygeno.2026.111324_bb0060","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41571-020-0388-9","article-title":"Personalized early detection and prevention of breast cancer: ENVISION consensus statement","volume":"17","author":"Pashayan","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"16_suppl","key":"10.1016\/j.ygeno.2026.111324_bb0065","article-title":"Diagnostic accuracy of the CxPREVENTIVE breast model for early detection of breast cancer","volume":"40","author":"Calleja","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2026.111324_bb0070","doi-asserted-by":"crossref","first-page":"viii65","DOI":"10.1093\/annonc\/mdy270.198","article-title":"Molecular subtyping of breast cancer by dedicated breast PET","volume":"29","author":"Sueoka","year":"2018","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111324_bb0075","first-page":"C343","article-title":"Heterogeneity within molecular subtypes of breast cancer","volume":"321","author":"Turner","year":"2021","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-022-01505-z","article-title":"Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring","volume":"21","author":"Li","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-022-01351-y","article-title":"Liquid biopsy: current technology and clinical applications","volume":"15","author":"Nikanjam","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12943-023-01715-z","article-title":"Clinical application and detection techniques of liquid biopsy in gastric cancer","volume":"22","author":"Ma","year":"2023","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.ygeno.2026.111324_bb0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41591-020-0915-3","article-title":"Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring","volume":"26","author":"Zviran","year":"2020","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.ygeno.2026.111324_bb0100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.molmed.2024.03.007","article-title":"Cell-free DNA methylation in the clinical management of lung cancer","volume":"30","author":"Ezegbogu","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ygeno.2026.111324_bb0105","article-title":"A liquid biopsy analysis of exosomal miRNA to detect lymph node metastasis in early gastric cancer","author":"Wada","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2026.111324_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.annonc.2025.03.017","article-title":"Editorial: liquid biopsy in gliomas \u2013 are we there yet?","author":"Baldini","year":"2025","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0115","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.7150\/thno.106459","article-title":"Advances in subpopulation separation and detection of extracellular vesicles: for liquid biopsy and downstream research","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/hep.30805","article-title":"Tumor-specific transcripts are frequently expressed in hepatocellular carcinoma with clinical implication and potential function","volume":"71","author":"Zheng","year":"2020","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"17","key":"10.1016\/j.ygeno.2026.111324_bb0125","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.7150\/thno.99245","article-title":"Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer diagnosis","volume":"14","author":"Kim","year":"2024","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0130","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/s41467-021-22444-1","article-title":"A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection","volume":"12","author":"Larson","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0135","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240559","article-title":"tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells","volume":"222","author":"Miao","year":"2025","journal-title":"J. Exp. Med."},{"issue":"49","key":"10.1016\/j.ygeno.2026.111324_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add0005","article-title":"Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41467-023-44461-y","article-title":"Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ygeno.2026.111324_bb0150","author":"GENCODE - human release 41 [Internet]"},{"issue":"12","key":"10.1016\/j.ygeno.2026.111324_bb0155","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2026.111324_bb0160","series-title":"pheatmap: pretty heatmaps [Internet]","author":"Kolde","year":"2019"},{"key":"10.1016\/j.ygeno.2026.111324_bb0165","first-page":"2825","article-title":"Scikit-learn: machine learning in python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"issue":"60","key":"10.1016\/j.ygeno.2026.111324_bb0170","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"seaborn: statistical data visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J. Open Source Softw."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0175","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: a 2D graphics environment","volume":"9","author":"Hunter","year":"2007","journal-title":"Comput Sci Eng."},{"key":"10.1016\/j.ygeno.2026.111324_bb0180","author":"GDC data portal homepage [Internet]"},{"key":"10.1016\/j.ygeno.2026.111324_bb0185","author":"CIBERSORTx [Internet]"},{"issue":"11","key":"10.1016\/j.ygeno.2026.111324_bb0190","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.ygeno.2026.111324_bb0195","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ygeno.2026.111324_bb0200","article-title":"Mapping single-cell developmental potential in health and disease with interpretable deep learning","author":"Kang","year":"2024","journal-title":"Biorxiv Prepr. Serv. Biol."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"issue":"43","key":"10.1016\/j.ygeno.2026.111324_bb0210","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0215","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.ygeno.2026.111324_bb0220","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/biom14111352","article-title":"Integrated miRNA signatures: advancing breast cancer diagnosis and prognosis","volume":"14","author":"Samara","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ygeno.2026.111324_bb0225","article-title":"Simultaneous detection of membrane protein and mRNA at single extracellular vesicle level by droplet microfluidics for cancer diagnosis","volume":"24","author":"Lin","year":"2024","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0230","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12943-019-1000-8","article-title":"Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0235","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12943-020-01280-9","article-title":"Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer","volume":"19","author":"Gu","year":"2020","journal-title":"Mol. Cancer"},{"issue":"16","key":"10.1016\/j.ygeno.2026.111324_bb0240","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1007\/s00018-016-2217-y","article-title":"Nucleoside modifications in the regulation of gene expression: focus on tRNA","volume":"73","author":"Duechler","year":"2016","journal-title":"Cell Mol Life Sci CMLS."},{"issue":"S1","key":"10.1016\/j.ygeno.2026.111324_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.00158","article-title":"The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer","volume":"34","author":"Kay","year":"2020","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ygeno.2026.111324_bb0250","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s42003-021-02805-8","article-title":"DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer","volume":"4","author":"Shen","year":"2021","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.ygeno.2026.111324_bb0255","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.201005141","article-title":"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism","volume":"190","author":"Hiramoto-Yamaki","year":"2010","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.ygeno.2026.111324_bb0260","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1002\/jcp.26792","article-title":"EGFL7: master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis","volume":"233","author":"Hong","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"23","key":"10.1016\/j.ygeno.2026.111324_bb0265","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1158\/0008-5472.CAN-11-1301","article-title":"Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation","volume":"71","author":"Delfortrie","year":"2011","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.ygeno.2026.111324_bb0270","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1158\/2326-6066.CIR-22-0218","article-title":"DKK1 promotes tumor immune evasion and impedes anti-PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer","volume":"10","author":"Shi","year":"2022","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.ygeno.2026.111324_bb0275","article-title":"G3BP1 and SLU7 jointly promote immune evasion by downregulating MHC-I via PI3K\/akt activation in bladder cancer","volume":"11","author":"Zheng","year":"2024","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"issue":"10","key":"10.1016\/j.ygeno.2026.111324_bb0280","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1158\/2159-8290.CD-16-0716","article-title":"Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis, and immunotherapy","volume":"6","author":"Okkenhaug","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ygeno.2026.111324_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217112","article-title":"PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer","volume":"598","author":"Zhang","year":"2024","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111324_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/bcr569","article-title":"Akt kinases in breast cancer and the results of adjuvant therapy","volume":"5","author":"St\u00e5l","year":"2003","journal-title":"Breast Cancer Res."},{"issue":"2","key":"10.1016\/j.ygeno.2026.111324_bb0295","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1530\/ERC-15-0461","article-title":"FOXO factors and breast cancer: outfoxing endocrine resistance","volume":"23","author":"Bullock","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ygeno.2026.111324_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108764","article-title":"EGFL7: an emerging biomarker with great therapeutic potential","volume":"266","author":"Fabian","year":"2025","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.ygeno.2026.111324_bb0305","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood-2011-10-322446","article-title":"EGFL7: a unique angiogenic signaling factor in vascular development and disease","volume":"119","author":"Nichol","year":"2012","journal-title":"Blood"}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326001321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754326001321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:38:07Z","timestamp":1793954287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754326001321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0888754326001321"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111324","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative profiling of multi-modal plasma cfRNA signatures enables detection and prognostic risk stratification in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2026.111324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111324"}}