{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:22:46Z","timestamp":1773922966242,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.ygyno.2005.01.024","type":"journal-article","created":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T14:42:40Z","timestamp":1111156960000},"page":"476-482","source":"Crossref","is-referenced-by-count":77,"title":["Outcome of surveillance and prophylactic salpingo-oophorectomy in asymptomatic women at high risk for ovarian cancer"],"prefix":"10.1016","volume":"97","author":[{"given":"Paul A.M.","family":"Meeuwissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Seynaeve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile T.M.","family":"Brekelmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne J.","family":"Meijers-Heijboer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.M.","family":"Klijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt W.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2005.01.024_bib1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2005.01.024_bib2","first-page":"496","article-title":"Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from three U.S. population-based case-control studies of ovarian cancer","volume":"60","author":"Whittemore","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2005.01.024_bib3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/jnci\/94.18.1365","article-title":"Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program","volume":"94","author":"Brose","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2005.01.024_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(94)91578-4","article-title":"Risks of cancer in BRCA1-mutation carriers. Breast cancer linkage consortium","volume":"343","author":"Ford","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2005.01.024_bib5","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast cancer linkage consortium","volume":"56","author":"Easton","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2005.01.024_bib6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/318181","article-title":"Variation in cancer risks, by mutation position, in BRCA2 mutation carriers","volume":"68","author":"Thompson","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2005.01.024_bib7","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/jnci\/91.15.1310","article-title":"Cancer risks in BRCA2 mutation carriers","volume":"91","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2005.01.024_bib8","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2005.01.024_bib9","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1471-0528.1998.tb09966.x","article-title":"The performance of screening tests for ovarian cancer: results of a systematic review","volume":"105","author":"Bell","year":"1998","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib10","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1080\/j.1600-0412.1999.781013.x","article-title":"Prospectively detected cancer in familial breast\/ovarian cancer screening","volume":"78","author":"Dorum","year":"1999","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.ygyno.2005.01.024_bib11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0140-6736(98)10261-1","article-title":"Screening for ovarian cancer: a pilot randomised controlled trial","volume":"353","author":"Jacobs","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2005.01.024_bib12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0002-9378(99)70663-0","article-title":"Peritoneal serous papillary carcinoma, a phenotypic variant of familial ovarian cancer: implications for ovarian cancer screening","volume":"180","author":"Karlan","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/1097-0142(20000801)89:3<582::AID-CNCR13>3.0.CO;2-#","article-title":"Usefulness of mass screening for ovarian carcinoma using transvaginal ultrasonography","volume":"89","author":"Sato","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2005.01.024_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1006\/gyno.2000.5816","article-title":"The efficacy of transvaginal sonographic screening in asymptomatic women at risk for ovarian cancer","volume":"77","author":"van Nagell","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1006\/gyno.2000.5983","article-title":"Long-term follow-up of the Stockholm screening study on ovarian cancer","volume":"79","author":"Einhorn","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib16","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1200\/JCO.20.5.1260","article-title":"Outcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriers","volume":"20","author":"Scheuer","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1200\/JCO.2001.19.4.924","article-title":"Effectiveness of breast cancer surveillance in BRCA1\/2 gene mutation carriers and women with high familial risk","volume":"19","author":"Brekelmans","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM200107193450301","article-title":"Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation","volume":"345","author":"Meijers-Heijboer","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2005.01.024_bib19","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/S0140-6736(00)02347-3","article-title":"Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation","volume":"355","author":"Meijers-Heijboer","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2005.01.024_bib20","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bmj.306.6884.1025","article-title":"Screening for early familial ovarian cancer with transvaginal ultrasonography and colour blood flow imaging","volume":"306","author":"Bourne","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.ygyno.2005.01.024_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/scbi.1998.0114","article-title":"CA 125: fundamental and clinical aspects","volume":"9","author":"Verheijen","year":"1999","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib22","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0002-9378(11)91720-7","article-title":"The effect of the menstrual cycle on serum CA 125 levels: a population study","volume":"167","author":"Grover","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib23","first-page":"511","article-title":"Factors influencing serum CA 125 levels in normal women","volume":"79","author":"Grover","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/gyno.1993.1239","article-title":"Screening for ovarian cancer: the preliminary experience of a familial ovarian cancer center","volume":"51","author":"Muto","year":"1993","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib25","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1097-0142(19951115)76:10+<2004::AID-CNCR2820761317>3.0.CO;2-G","article-title":"Toward an optimal algorithm for ovarian cancer screening with longitudinal tumor markers","volume":"76","author":"Skates","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2005.01.024_bib26","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1002\/1097-0142(19951115)76:10+<2092::AID-CNCR2820761331>3.0.CO;2-T","article-title":"Ovarian cancer screening. The use of serial complementary tumor markers to improve sensitivity and specificity for early detection","volume":"76","author":"Berek","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2005.01.024_bib27","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1471-0528.1993.tb15177.x","article-title":"Differential diagnosis of ovarian cancer with tumour markers CA 125, CA 15-3 and TAG 72.3","volume":"100","author":"Jacobs","year":"1993","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00001703-200102000-00004","article-title":"Current status of prophylactic surgery for hereditary breast and gynecologic cancers","volume":"13","author":"Lynch","year":"2001","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/gyno.1993.1238","article-title":"A morphology index based on sonographic findings in ovarian cancer","volume":"51","author":"De Priest","year":"1993","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1469-0705.2000.00287.x","article-title":"Terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the international ovarian tumor analysis (IOTA) group","volume":"16","author":"Timmerman","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/096914139400100404","article-title":"Feasibility study of a randomised trial of ovarian cancer screening among the general population","volume":"1","author":"Parkes","year":"1994","journal-title":"J. Med. Screen."},{"key":"10.1016\/j.ygyno.2005.01.024_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/gyno.1999.5647","article-title":"Three-dimensional ultrasound and power doppler improve the diagnosis of ovarian lesions","volume":"76","author":"Kurjak","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib33","first-page":"33","article-title":"Prophylactic oophorectomy in inherited breast\/ovarian cancer families","author":"Struewing","year":"1995","journal-title":"J. Natl. Cancer Inst. Monogr."},{"issue":"21","key":"10.1016\/j.ygyno.2005.01.024_bib34","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa020119","article-title":"Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation","volume":"346","author":"Kauff","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.ygyno.2005.01.024_bib35","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1056\/NEJMoa012158","article-title":"Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations","volume":"346","author":"Rebbeck","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2005.01.024_bib36","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cncr.2820710214","article-title":"Familial ovarian cancer. A report of 658 families from the Gilda Radner Familial Ovarian Cancer Registry 1981\u20131991","volume":"71","author":"Piver","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2005.01.024_bib37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM199808133390702","article-title":"Oral contraceptives and the risk of hereditary ovarian cancer. Hereditary Ovarian Cancer Clinical Study Group","volume":"339","author":"Narod","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2005.01.024_bib38","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(00)04642-0","article-title":"Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study","volume":"357","author":"Narod","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2005.01.024_bib39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/gyno.2001.6290","article-title":"Occult cancer in the fallopian tube in patients with a BRCA-1 germline mutation","volume":"83","author":"Ansink","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/gyno.2001.6257","article-title":"Prophylactic surgery in patients with inherited risk of ovarian cancer","volume":"83","author":"Morice","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib41","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/jama.277.12.997","article-title":"Recommendations for follow-up care of individuals with an inherited predisposition to cancer","volume":"277","author":"Burke","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.ygyno.2005.01.024_bib42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1634\/theoncologist.1-5-326","article-title":"Prophylactic oophorectomy: reducing the U.S. death rate from epithelial ovarian cancer. A continuing debate","volume":"1","author":"Piver","year":"1996","journal-title":"Oncologist"},{"key":"10.1016\/j.ygyno.2005.01.024_bib43","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1200\/JCO.2000.18.9.1980","article-title":"Prophylactic surgery in women with a hereditary predisposition to breast and ovarian cancer","volume":"18","author":"Eisen","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.273.6.491","article-title":"Ovarian cancer. Screening, treatment, and follow-up. NIH consensus development panel on ovarian cancer","volume":"273","author":"AnonymousNIH consensus conference","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ygyno.2005.01.024_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/gyno.2000.5740","article-title":"Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a case report","volume":"77","author":"Rose","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/gyno.1999.5623","article-title":"Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations","volume":"76","author":"Zweemer","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib47","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/gyno.2000.6071","article-title":"Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis","volume":"80","author":"Paley","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1067\/mob.2002.119187","article-title":"Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening","volume":"186","author":"Hebert-Blouin","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib49","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/1097-0142(19951015)76:8<1416::AID-CNCR2820760818>3.0.CO;2-D","article-title":"Risks of cancer among members of families in the Gilda Radner Familial Ovarian Cancer Registry","volume":"76","author":"Jishi","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2005.01.024_bib50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/gyno.2000.6082","article-title":"Risk of endometrial carcinoma associated with BRCA mutation","volume":"80","author":"Levine","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0029-7844(00)00851-6","article-title":"BRCA1 germline mutations in women with uterine serous papillary carcinoma","volume":"96","author":"Lavie","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib52","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/jnci\/94.18.1358","article-title":"Cancer incidence in BRCA1 mutation carriers","volume":"94","author":"Thompson","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2005.01.024_bib53","first-page":"325","article-title":"The Gilda Radner Familial Ovarian Cancer Registry 1981\u20132000","volume":"21","author":"Piver","year":"2000","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.01.024_bib54","article-title":"Effectiveness of prophylactic oophorectomy in inherited breast\/ovarian cancer families","volume":"A384","author":"Struewing","year":"1994","journal-title":"Am. J. Hum. Genet."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825805000752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825805000752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:26:43Z","timestamp":1586172403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825805000752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0090825805000752"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2005.01.024","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}