{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:36:28Z","timestamp":1783128988843,"version":"3.54.6"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.ygyno.2005.12.024","type":"journal-article","created":{"date-parts":[[2006,1,28]],"date-time":"2006-01-28T12:10:36Z","timestamp":1138450236000},"page":"353-355","source":"Crossref","is-referenced-by-count":38,"title":["Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: A case report and review of the literature"],"prefix":"10.1016","volume":"101","author":[{"given":"Mehdi M.","family":"Kebria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Belinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek M.","family":"Mekhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2005.12.024_bib1","first-page":"265","article-title":"Malignant acanthosis nigricans","volume":"3","author":"Andreev","year":"1984","journal-title":"Semin. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(94)70128-8","article-title":"Acanthosis nigricans","volume":"31","author":"Schwartz","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaad.2004.09.028","article-title":"Hyperkeratosis of the nipple associated with acanthosis nigricans: treatment with topical calcipotriol","volume":"52\u20133","author":"Lee","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1365-4632.2004.02159.x","article-title":"Oral acanthosis nigricans, tripe palms and sign of Leser-Tr\u00e9lat in a patient with gastric adenocarcinoma","volume":"43","author":"Pentenero","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(94)70128-8","article-title":"Acanthosis nigricans","volume":"31","author":"Schwartz","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0738-081X(93)90076-O","article-title":"Acanthosis nigricans","volume":"11","author":"Matsuoka","year":"1993","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1056\/NEJM197604012941401","article-title":"The syndromes of insulin resistance and acanthosis nigricans: insulin receptor disorder in man","volume":"294","author":"Kahn","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2005.12.024_bib8","first-page":"319","article-title":"Acanthosis nigricans, florid cutaneous paplillomatosis and the sign of Leser-Tre'lat","volume":"28","author":"Schwartz","year":"1981","journal-title":"Cutis"},{"key":"10.1016\/j.ygyno.2005.12.024_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2230.1980.tb01686.x","article-title":"Acanthosis palmaris: tripe palms. A distinctive pattern of palmar keratoderma frequently associated with internal malignancy","volume":"5","author":"Breathnach","year":"1980","journal-title":"Clin. Exp. Dermatol."},{"issue":"5","key":"10.1016\/j.ygyno.2005.12.024_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1200\/JCO.1989.7.5.669","article-title":"Tripe palms and malignancy","volume":"7","author":"Cohen","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0738-081X(93)90114-R","article-title":"Tripe palms and cancer","volume":"11","author":"Cohen","year":"1993","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0738-081X(93)90111-O","article-title":"Sign of Leser-Trelat","volume":"11","author":"Ellis","year":"1993","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0190-9622(96)90502-2","article-title":"Sign of Leser-Tr\u00e9lat","volume":"35","author":"Schwartz","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/gyno.1997.4674","article-title":"Case report: malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma\u2014A case report and review of literature","volume":"65","author":"Gorisek","year":"1997","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-0142(196203\/04)15:2<364::AID-CNCR2820150220>3.0.CO;2-M","article-title":"The site and histology of the cancers associated with acanthosis nigricans","volume":"15","author":"Curth-Ollendorff","year":"1962","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.ygyno.2005.12.024_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ejim.2004.06.014","article-title":"Acanthosis nigricans associated with acute myeloid leukaemia","volume":"15","author":"Badawi","year":"2004","journal-title":"Eur. J. Int. Med."},{"key":"10.1016\/j.ygyno.2005.12.024_bib17","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0022-5347(05)66369-0","article-title":"Tripe palms and malignant acanthosis nigricans: cutaneous signs of imminent metastasis in bladder cancer","volume":"165","author":"Hrenschlager","year":"2001","journal-title":"J. Urol."},{"issue":"8","key":"10.1016\/j.ygyno.2005.12.024_bib18","first-page":"920","article-title":"Malignant acanthosis nigricans in adrenal carcinoma","volume":"32","author":"Hiranandani","year":"1995","journal-title":"Indian Pediatr."},{"issue":"5","key":"10.1016\/j.ygyno.2005.12.024_bib19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2340\/0001555573378379","article-title":"Acanthosis nigricans and bile duct malignancy","volume":"73","author":"Ravnborg","year":"1993","journal-title":"Acta Derm. Venereol."},{"issue":"3","key":"10.1016\/j.ygyno.2005.12.024_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000248689","article-title":"Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma. Report of 2 cases","volume":"176","author":"Janier","year":"1988","journal-title":"Dermatologica"},{"issue":"3","key":"10.1016\/j.ygyno.2005.12.024_bib21","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archderm.106.3.384","article-title":"Malignant acanthosis nigricans associated with osteogenic sarcoma","volume":"106","author":"Garrott","year":"1972","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/archsurg.1943.01220180003001","article-title":"Cancer associated acanthosis nigricans: review of the literature and report of a case of acanthosis nigricans with cancer of the breast","volume":"47","author":"Curth","year":"1943","journal-title":"Arch. Surg."},{"key":"10.1016\/j.ygyno.2005.12.024_bib23","first-page":"141","article-title":"Malignant acanthosis nigricans associated with endometrial adenocarcinoma","volume":"8","author":"Curth","year":"1962","journal-title":"Bull Sloane Hosp. Wom. NY"},{"key":"10.1016\/j.ygyno.2005.12.024_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/gyno.1997.4674","article-title":"Malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma\u2014A case report and review of the literature","volume":"65","author":"Gorisek","year":"1997","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2005.12.024_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/archderm.115.2.201","article-title":"Generalized malignant acanthosis nigricans","volume":"115","author":"Mikhail","year":"1979","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000249721","article-title":"Acanthosis nigricans maligna","volume":"168","author":"Gross","year":"1984","journal-title":"Dermatologica"},{"issue":"2","key":"10.1016\/j.ygyno.2005.12.024_bib27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1006\/gyno.2001.6472","article-title":"Acanthosis nigricans with endometrial carcinoma: case report and review of the literature","volume":"84","author":"Mekhail","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib28","first-page":"441","article-title":"Growth in continuous culture, and in hamsters, of cells from a neoplasm associated with acanthosis nigricans","volume":"33","author":"Dawe","year":"1964","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2005.12.024_bib29","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1056\/NEJM198712173172506","article-title":"Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multiple acrocondrons: a possible role for alpha transforming growth factor in cutaneous paraneoplastic syndromes","volume":"317","author":"Ellis","year":"1987","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ygyno.2005.12.024_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01213299","article-title":"Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus","volume":"32","author":"Koyoma","year":"1997","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ygyno.2005.12.024_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1200\/JCO.1989.7.5.669","article-title":"Tripe palms and malignancy","volume":"7","author":"Cohen","year":"1989","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ygyno.2005.12.024_bib32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1046\/j.1365-2133.1999.03116.x","article-title":"Malignant acanthosis nigricans: potential role of chemotherapy","volume":"141","author":"Anderson","year":"1999","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.ygyno.2005.12.024_bib33","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1346-8138.1995.tb03430.x","article-title":"Tripe palms: a cutaneous marker of internal malignancy","volume":"22","author":"Requena","year":"1995","journal-title":"J. Dermatol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825805011297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825805011297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T16:22:48Z","timestamp":1706890968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825805011297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0090825805011297"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2005.12.024","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}