{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:51:15Z","timestamp":1773683475124,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.ygyno.2007.08.082","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T11:30:49Z","timestamp":1191324649000},"page":"S138-S146","source":"Crossref","is-referenced-by-count":41,"special_numbering":"S","title":["The clinical effectiveness of optical spectroscopy for the in vivo diagnosis of cervical intraepithelial neoplasia: Where are we?"],"prefix":"10.1016","volume":"107","author":[{"given":"Marylou","family":"Cardenas-Turanzas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Adrian","family":"Freeberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Benedet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Neely","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis D.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Richards-Kortum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calum","family":"MacAulay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Follen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B.","family":"Cantor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2007.08.082_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1367-5931(02)00381-2","article-title":"Optical spectroscopy for detection of neoplasia","volume":"6","author":"Sokolov","year":"2002","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib2","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/cncr.11678","article-title":"Optical imaging of the cervix","volume":"98","author":"Drezek","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2007.08.082_bib3","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMoa020586","article-title":"A controlled trial of a human papillomavirus type 16 vaccine","volume":"347","author":"Koutsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2007.08.082_bib4","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0140-6736(04)17398-4","article-title":"Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women, a randomised controlled trial","volume":"364","author":"Harper","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2007.08.082_bib5","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.vaccine.2005.01.016","article-title":"Vaccination against human papillomavirus infection: a new paradigm in cervical cancer control","volume":"23","author":"Franco","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.ygyno.2007.08.082_bib6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0140-6736(05)67069-9","article-title":"Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis","volume":"366","author":"Clifford","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2007.08.082_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.297.8.813","article-title":"Prevalence of HPV infection among females in the United States","volume":"297","author":"Dunne","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ygyno.2007.08.082_bib8","doi-asserted-by":"crossref","first-page":"10229","DOI":"10.1158\/0008-5472.CAN-06-0630","article-title":"Prospects for cervical cancer prevention by human papillomavirus vaccination","volume":"66","author":"Schiller","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2007.08.082_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/bmj.296.6627.975","article-title":"Organisation and results of the cervical cytology screening programme in British Columbia, 1955\u201385","volume":"296","author":"Anderson","year":"1988","journal-title":"Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.ygyno.2007.08.082_bib10","first-page":"872","article-title":"A quality-control program for colposcopic practice","volume":"78","author":"Benedet","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib11","unstructured":"Anonymous. Electro-optical sensors for the in vivo detection of cervical cancer and its precursors: submission guidance for an IDE\/PMA. Rockville, MD: Food and Drug Administration. 1999 05\/21\/1999:Report No.: 266."},{"key":"10.1016\/j.ygyno.2007.08.082_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1471-0528.2002.01311.x","article-title":"Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasia","volume":"109","author":"Weingandt","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.ygyno.2007.08.082_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/gyno.1994.1007","article-title":"Fluorescence spectroscopy\u2014a diagnostic-tool for cervical intraepithelial neoplasia (CIN)","volume":"52","author":"Ramanujam","year":"1994","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/(SICI)1096-9101(1996)19:1<46::AID-LSM7>3.0.CO;2-Q","article-title":"Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo","volume":"19","author":"Ramanujam","year":"1996","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.ygyno.2007.08.082_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1096-9101(1996)19:1<63::AID-LSM8>3.0.CO;2-O","article-title":"Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser-induced fluorescence spectra at multiple excitation wavelengths","volume":"19","author":"Ramanujam","year":"1996","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.ygyno.2007.08.082_bib16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0029-7844(98)00385-8","article-title":"Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix","volume":"93","author":"Mitchell","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0029-7844(99)00408-1","article-title":"Screening for squamous intraepithelial lesions with fluorescence spectroscopy","volume":"94","author":"Mitchell","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib18","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1109\/TBME.2002.803597","article-title":"Optimal excitation wavelengths for discrimination of cervical neoplasia","volume":"49","author":"Chang","year":"2002","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.ygyno.2007.08.082_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/gyno.2001.6370","article-title":"Shanxi province cervical cancer screening study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia","volume":"83","author":"Belinson","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00128360-200004030-00001","article-title":"Multispectral diagnostic imaging of the cervix: report on a new investigational device","volume":"4","author":"Parker","year":"2000","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ygyno.2007.08.082_bib21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1067\/mob.2002.123940","article-title":"Initial neural net construction for the detection of cervical intraepithelial neoplasia by fluorescence imaging","volume":"187","author":"Parker","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib22","first-page":"45","article-title":"Detection of cervical squamous intraepithelial lesions using evoked tissue fluorescence. abstracts presented for the Thirtieth Annual Meeting of the Society of Gynecologic Oncologists","volume":"72","author":"Wright","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib23","series-title":"Annual reports of the Research Reactor Institute, Kyoto University","first-page":"3150","article-title":"Preliminary experimental results from multi-center clinical trials for detection of cervical precancerous lesions using the Cerviscan system: a novel full-field evoked tissue fluorescence based imaging instrument","author":"Dattamajumdar","year":"2001"},{"key":"10.1016\/j.ygyno.2007.08.082_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1525-1438.1994.04020079.x","article-title":"An electronic approach to the detection of precancer and cancer of the uterine cervix\u2014a preliminary evaluation of polarprobe","volume":"4","author":"Coppleson","year":"1994","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2007.08.082_bib25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1525-1438.2003.13393.x","article-title":"A real time optoelectronic device as an adjunct to the Pap smear for cervical screening: a multicenter evaluation","volume":"13","author":"Singer","year":"2003","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2007.08.082_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1117\/1.1502675","article-title":"Reflectance spectroscopy for in vivo detection of cervical precancer","volume":"7","author":"Mirabal","year":"2002","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.ygyno.2007.08.082_bib27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ygyno.2007.01.001","article-title":"In vivo light scattering measurements for detection of precancerous conditions of the cervix","volume":"105","author":"Mourant","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ygyno.2004.09.013","article-title":"A clinical study of optical biopsy of the uterine cervix using a multispectral imaging system","volume":"96","author":"Orfanoudaki","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/mob.2002.121075","article-title":"Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo","volume":"186","author":"Georgakoudi","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib30","doi-asserted-by":"crossref","first-page":"024031","DOI":"10.1117\/1.1899686","article-title":"Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer","volume":"10","author":"Chang","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.ygyno.2007.08.082_bib31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1526-0976.2001.005002065.x","article-title":"Multimodal multispectral imaging for the noninvasive diagnosis of cervical neoplasia","volume":"5","author":"Ferris","year":"2001","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ygyno.2007.08.082_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.lgt.0000230207.50495.05","article-title":"Spectroscopic imaging as a triage test for cervical disease: a prospective multicenter clinical trial","volume":"11","author":"DeSantis","year":"2007","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ygyno.2007.08.082_bib33","first-page":"90","article-title":"Use of autofluorescence of cells to evaluate cervical neoplasia","volume":"2","author":"Burke","year":"1996","journal-title":"J. Gynecol. Tech."},{"key":"10.1016\/j.ygyno.2007.08.082_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1526-0976.1999.08109.x","article-title":"Identification of squamous intraepithelial lesions: fluorescence of cervical tissue during colposcopy","volume":"3","author":"Burke","year":"1999","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ygyno.2007.08.082_bib35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/lsm.1097","article-title":"Identification of cervical intraepithelial neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy","volume":"29","author":"Nordstrom","year":"2001","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.ygyno.2007.08.082_bib36","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.ajog.2003.12.006","article-title":"Optical detection of high-grade cervical intraepithelial neoplasia in vivo: results of a 604-patient study","volume":"190","author":"Huh","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ygyno.2006.08.056","article-title":"Optical Detection Group. Effective cervical neoplasia detection with a novel optical detection system: a randomized trial","volume":"104","author":"Alvarez","year":"2007","journal-title":"Gynecol .Oncol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00001888-199207000-00002","article-title":"Technology assessment in medicine","volume":"67","author":"Littenberg","year":"1992","journal-title":"Acad. Med."},{"key":"10.1016\/j.ygyno.2007.08.082_bib39","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1366\/0003702934066244","article-title":"Optically dilute, absorbing, and turbid phantoms for fluorescence spectroscopy of homogeneous and inhomogeneous samples","volume":"47","author":"Durkin","year":"1993","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.ygyno.2007.08.082_bib40","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1364\/AO.33.000414","article-title":"Relation between fluorescence spectra of dilute and turbid samples","volume":"33","author":"Durkin","year":"1994","journal-title":"Appl. Opt."},{"key":"10.1016\/j.ygyno.2007.08.082_bib41","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1562\/0031-8655(2000)071<0730:APISTC>2.0.CO;2","article-title":"Autofluorescence patterns in short-term cultures of normal cervical tissue","volume":"71","author":"Brookner","year":"2000","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib42","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1117\/1.1413209","article-title":"Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications","volume":"6","author":"Drezek","year":"2001","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.ygyno.2007.08.082_bib43","first-page":"682","article-title":"NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes","volume":"62","author":"Georgakoudi","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2007.08.082_bib44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1364\/OE.5.000302","article-title":"Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology","volume":"5","author":"Sokolov","year":"1999","journal-title":"Opt. Express"},{"key":"10.1016\/j.ygyno.2007.08.082_bib45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00128360-200310000-00013","article-title":"Women's responses to cervical interrogation by fluorescent and reflective spectroscopy","volume":"7","author":"Ferris","year":"2003","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ygyno.2007.08.082_bib46","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1067\/S0002-9378(03)00540-4","article-title":"Patient distress and satisfaction with optical spectroscopy in cervical dysplasia detection","volume":"189","author":"Basen-Engquist","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0029-7844(97)00623-6","article-title":"Cost-effectiveness analysis of diagnosis and management of cervical squamous intraepithelial lesions","volume":"91","author":"Cantor","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/ijc.20190","article-title":"Accuracy of visual screening for cervical neoplasia: results from an IARC multicentre study in India and Africa","volume":"110","author":"Sankaranarayanan","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygyno.2007.08.082_bib49","unstructured":"International Agency for Research on Cancer-IARC Screening Group. Accuracy of screening tests. http:\/\/screening.iarc.fr\/study_acc.php?lang=1. Accessed March 18, 2007."},{"key":"10.1016\/j.ygyno.2007.08.082_bib50","unstructured":"McCrory DC, Mather DB, Bastian L, et al. Evaluation of cervical cytology. Evidence Report\/Technology Assessment No.5 (Prepared by Duke University under Contract No. 290-97-0014). AHCPR Publication No. 99-E010.Rockville, MD. Agency for Health Policy and Research, February 1999."},{"key":"10.1016\/j.ygyno.2007.08.082_bib51","doi-asserted-by":"crossref","unstructured":"Fahey, MT, Irwig L, Macaskill P. Meta-analysis of Pap test accuracy. Am J Epidemiol. 141:680\u20139.","DOI":"10.1093\/oxfordjournals.aje.a117485"},{"key":"10.1016\/j.ygyno.2007.08.082_bib52","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cncr.21993","article-title":"DNA ploidy compared with human papillomvirus testing (Hybrid Capture II) and conventional cytology as a primary screening test for cervical high-grade lesions and cancer in 1555 patients with biopsy confirmation","volume":"107","author":"Guillaud","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2007.08.082_bib53","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0029-7844(98)00006-4","article-title":"Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis","volume":"91","author":"Mitchell","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib54","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0002-9378(03)00418-6","article-title":"A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations","volume":"188","author":"The ASCUS-LGSIL Trial Study (ALTS) Group","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2007.08.082_bib55","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.AOG.0000220505.18525.85","article-title":"Number of cervical biopsies and sensitivity of colposcopy","volume":"108","author":"Gage","year":"2006","journal-title":"Obstet. Gynecol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825807006932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825807006932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T13:14:09Z","timestamp":1556889249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825807006932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0090825807006932"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2007.08.082","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}