{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:06:20Z","timestamp":1770822380325,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.ygyno.2008.06.032","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T04:09:50Z","timestamp":1218341390000},"page":"120-124","source":"Crossref","is-referenced-by-count":21,"title":["P16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies"],"prefix":"10.1016","volume":"111","author":[{"given":"Carmen M.","family":"Gurrola-D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel E.","family":"Su\u00e1rez-Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"V\u00e1zquez-Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Buonocunto-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Rosales-Quintana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"von Knebel Doeberitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2008.06.032_bib1","doi-asserted-by":"crossref","unstructured":"Direcci\u00f3n General de Informaci\u00f3n en Salud, Secretar\u00eda de Salud, M\u00e9xico. Mexico's mortality statistics. Deaths registered in 2003. Salud Publica Mex 2005; 47:171-87.","DOI":"10.1590\/S0036-36342005000200013"},{"key":"10.1016\/j.ygyno.2008.06.032_bib2","unstructured":"Norma Oficial Mexicana (1994) and last modification, available from: http:\/\/www.hgm.sald.gob.mx\/servmed\/nom_014_zssa2_1994.pdf and http:\/\/www.salud.gob.mx\/unidades\/cdi\/nom\/m014ssa24.html Accessed 4 June 2007."},{"key":"10.1016\/j.ygyno.2008.06.032_bib3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/jcp.49.10.833","article-title":"Interobserver variation in the reporting of cervical colposcopic biopsy specimens: comparison of grading systems","volume":"49","author":"McCluggage","year":"1996","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib4","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1001\/jama.285.11.1500","article-title":"Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study","volume":"285","author":"Stoler","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ygyno.2008.06.032_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1525-1438.2006.00759.x","article-title":"Clinical applications of immunohistochemistry in gynecological malignancies","volume":"17","author":"Shutter","year":"2007","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1440-1827.2002.01359.x","article-title":"Overexpression of p16 and p14ARF isassociated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia","volume":"52","author":"Sano","year":"2002","journal-title":"Pathol. Int."},{"key":"10.1016\/j.ygyno.2008.06.032_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"Klaes","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib8","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0959-8049(02)00462-8","article-title":"New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections","volume":"38","author":"von-Knebel-Doeberitz","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cncr.21713","article-title":"Role of P16(INK4a) expressioninidentifying CIN2 or more severe lesions among HPV-positive patients referred for colposcopy after abnormal cytology","volume":"108","author":"Carozzi","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib10","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00000478-200211000-00001","article-title":"p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia","volume":"26","author":"Klaes","year":"2002","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/00003081-196712000-00002","article-title":"Natural history of cervical intraepithelial neoplasia","volume":"10","author":"Richart","year":"1967","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<440::AID-IJC22>3.0.CO;2-A","article-title":"Report on consensus conference on cervical cancer screening and management","volume":"86","author":"Miller","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.ygyno.2008.06.032_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1471-0528.1998.tb10054.x","article-title":"Inter- and intra-observer variation in the histopathological reporting of cervical squamous intraepithelial lesions using a modified Bethesda grading system","volume":"105","author":"McCluggage","year":"1998","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib15","first-page":"330","article-title":"Diagnostic reproducibility of Pap testing in two regions of Mexico: the need for quality control mechanisms","volume":"30","author":"de-Ruiz","year":"1996","journal-title":"Bull. Pan. Am. Health Organ."},{"key":"10.1016\/j.ygyno.2008.06.032_bib16","first-page":"111","article-title":"Diagnostic concordance in gynecologic cytology","volume":"49","author":"Lazcano-Ponce","year":"1997","journal-title":"Rev. Invest. Clin."},{"key":"10.1016\/j.ygyno.2008.06.032_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000332512","article-title":"Validity and reproducibility of cytologic diagnosis in a sample of cervical cancer screening centers in Mexico","volume":"41","author":"Lazcano-Ponce","year":"1997","journal-title":"Acta. Cytol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/(SICI)1097-0339(199707)17:1<20::AID-DC4>3.0.CO;2-T","article-title":"Reproducibility study of cervical cytopathology in Mexico: a need for regulation and professional accreditation","volume":"17","author":"Lazcano-Ponce","year":"1997","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jnci\/91.3.252","article-title":"Natural history of dysplasia of the uterine cervix","volume":"91","author":"Holowaty","year":"1999","journal-title":"J. Natl. Cancer. Inst."},{"key":"10.1016\/j.ygyno.2008.06.032_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/bmj.298.6675.707","article-title":"Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia","volume":"298","author":"Ismail","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.ygyno.2008.06.032_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/jcp.42.3.231","article-title":"Observer variability in histopathological reporting of cervical biopsy specimens","volume":"42","author":"Robertson","year":"1989","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ygyno.2008.06.032_bib22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s00428-004-1127-9","article-title":"p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri","volume":"445","author":"Negri","year":"2004","journal-title":"Virchows Arch."},{"key":"10.1016\/j.ygyno.2008.06.032_bib23","first-page":"206","article-title":"Measuring the reliability of clinical data: the case for using three observers","volume":"32","author":"Walter","year":"1984","journal-title":"Rev. Epidemiol. Sante Publique"},{"key":"10.1016\/j.ygyno.2008.06.032_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ijc.22172","article-title":"Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening tests","volume":"120","author":"Zhang","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygyno.2008.06.032_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ygyno.2006.01.033","article-title":"Usefulness of combining testing for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening","volume":"103","author":"Ekalaksananan","year":"2006","journal-title":"Gynecol. Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825808004964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825808004964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T02:14:46Z","timestamp":1557713686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825808004964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0090825808004964"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2008.06.032","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}