{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:40:34Z","timestamp":1763746834872,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.ygyno.2009.06.020","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T04:09:29Z","timestamp":1247458169000},"page":"127-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["p16INK4A in routine practice as a marker of cervical epithelial neoplasia"],"prefix":"10.1016","volume":"115","author":[{"given":"Fisnik","family":"Kurshumliu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Thorns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lumturije","family":"Gashi-Luci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2005","series-title":"Cervix Cancer Screening","author":"International Agency for Research on Cancer","key":"10.1016\/j.ygyno.2009.06.020_bb0005"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0010","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(06)69225-8","article-title":"The globalisation of cancer","volume":"368","author":"Boyle","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0015","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1309\/AGB1MJ9H5N43MEGX","article-title":"Assisted primary screening using the automated ThinPrep Imaging System","volume":"123","author":"Biscotti","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000325959","article-title":"Performance of an imaging system vs. manual screening in the detection of squamous intraepithelial lesions of the uterine cervix","volume":"50","author":"Dziura","year":"2006","journal-title":"Acta Cytol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1365-2303.2002.00403.x","article-title":"Comparative study: conventional cervical and ThinPrep Pap tests in a routine clinical setting","volume":"13","author":"Grace","year":"2002","journal-title":"Cytopathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0030","first-page":"443","article-title":"Viral latency \u2014 the papillomavirus model","volume":"106","author":"Broker","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0035","first-page":"1343","article-title":"A statistical model of the natural history of cervical carcinoma based on a prospective study of 557 cases","volume":"41","author":"Barron","year":"1968","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0040","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","article-title":"Overview of the European and North American studies on HPV testing in primary cervical cancer screening","volume":"119","author":"Cuzick","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0045","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1053\/hupa.2002.127439","article-title":"Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia","volume":"33","author":"Riethdorf","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0050","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1128\/JCM.37.4.1030-1034.1999","article-title":"Human papillomavirus DNA copy number is dependent on grade of cervical disease and HPV type","volume":"37","author":"Swan","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0055","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/01.aids.0000168972.65304.6b","article-title":"High levels of HPV-16 DNA are associated with high-grade cervical lesions in women at risk or infected with HIV","volume":"19","author":"Fontaine","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0060","first-page":"112","article-title":"p16INK4a as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: experience with squamous lesions in 189 consecutive cervical biopsies","volume":"37","author":"Dray","year":"2005","journal-title":"Anat Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/modpathol.3800290","article-title":"Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents","volume":"18","author":"Hu","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0070","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00000478-200107000-00006","article-title":"Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus- related cervical neoplasia","volume":"25","author":"Keating","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0075","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"Klaes","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0080","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0959-8049(02)00462-8","article-title":"New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections","volume":"38","author":"von Knebel Doeberitz","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0085","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00428-005-0141-x","article-title":"p16INK4A overexpression and HPV infection in uterine cervix adenocarcinoma","volume":"448","author":"Missaoui","year":"2006","journal-title":"Virchows Archiv"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ygyno.2004.11.034","article-title":"Is p16INK4a expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear \u2014 a comparative analysis using abnormal cervical smears with follow-up biopsies","volume":"97","author":"Nieh","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0095","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1159\/000333170","article-title":"False positive cervicovaginal cytology: a follow-up study","volume":"41","author":"Anderson","year":"1997","journal-title":"Acta Cytol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/oxfordjournals.aje.a117485","article-title":"Meta-analysis of Pap test accuracy","volume":"141","author":"Fahey","year":"1995","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0105","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1067\/mob.2002.123732","article-title":"Aberrant expression of E- cadherin in cervical intraepithelial neoplasia correlates with a false negative Papanicolaou smear","volume":"186","author":"Felix","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/01.MP.0000077518.78046.0C","article-title":"p16INK4a expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types","volume":"16","author":"Agoff","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0115","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/scbi.1999.0146","article-title":"The serological response to papillomaviruses","volume":"9","author":"Dillner","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0120","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1159\/000326578","article-title":"Immunocytochemical detection of p16INK4a protein in scraped cervical cells","volume":"47","author":"Pientong","year":"2003","journal-title":"Acta Cytol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.22580","article-title":"Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay. Correlation with biopsy follow-up results","volume":"111","author":"Meyer","year":"2007","journal-title":"Cancer Cytopathology"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0130","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1309\/0DGGQBDQAMJCJBXB","article-title":"The predictive value of p16INK4a and hybrid capture 2 human papilloma virus testing for high-grade cervical intraepithelial neoplasia","volume":"122","author":"Guo","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0135","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jmv.1890200310","article-title":"Detection of human papilloma- virus DNA by the nucleic acid sandwich hybridization method from cervical scraping","volume":"20","author":"Parkkinen","year":"1986","journal-title":"J Med Virol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0140","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0002-9378(03)00418-6","article-title":"Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance","volume":"188","author":"ASC-US LSIL Triage Study (ALTS) Group","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0145","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1159\/000326445","article-title":"Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples","volume":"48","author":"Trunk","year":"2004","journal-title":"Acta Cytologica"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0150","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cncr.21378","article-title":"Evaluation of nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples","volume":"105","author":"Wentzensen","year":"2005","journal-title":"Cancer Cytopathology"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00000478-200302000-00006","article-title":"p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations","volume":"27","author":"Negri","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ygyno.2009.06.020_bb0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/01.pgp.0000236942.51840.56","article-title":"The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix","volume":"26","author":"Hariri","year":"2007","journal-title":"Int J Gynecol Pathol"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825809004582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825809004582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:25:47Z","timestamp":1758770747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825809004582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0090825809004582"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2009.06.020","relation":{},"ISSN":["0090-8258"],"issn-type":[{"type":"print","value":"0090-8258"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p16INK4A in routine practice as a marker of cervical epithelial neoplasia","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2009.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}