{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:27:40Z","timestamp":1793921260274,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.ygyno.2012.07.106","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T07:14:39Z","timestamp":1343114079000},"page":"379-383","source":"Crossref","is-referenced-by-count":190,"title":["Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass"],"prefix":"10.1016","volume":"127","author":[{"given":"Mona Aarenstrup","family":"Karlsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ib Jarle","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Nedergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Lundvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend A.","family":"Engelholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette T.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorthe","family":"Hartwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Lydolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga Alice","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid V.S.","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2012.07.106_bb0005","series-title":"NORDCAN: cancer incidence, mortality, prevalence and survival in the Nordic countries, version 4.0","author":"Engholm","year":"2011"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0010","series-title":"Kr\u00e6ftprofil \u2014 \u00e6ggestokkr\u00e6ft 2000\u20132006","year":"2009"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0015","series-title":"Danish Gynecologic Cancer Database. A nationwide clinical database for cancer in ovaries, uterus and cervix","first-page":"1","article-title":"Year report 2009\/2010","author":"H\u00f8gdall","year":"2012"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0020","series-title":"Retningslinier for visitation, diagnostik og kontrol af epithelial ovarie-, tuba- og prim\u00e6r peritonealcancer samt borderline tumorer","year":"2000"},{"issue":"Suppl. 1","key":"10.1016\/j.ygyno.2012.07.106_bb0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1525-1438.2006.00319.x","article-title":"Improved short-term survival for advanced ovarian, tubal, and peritoneal cancer patients operated at teaching hospitals","volume":"16","author":"Paulsen","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0030","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ygyno.2005.07.008","article-title":"Who should operate on patients with ovarian cancer? An evidence-based review","volume":"99","author":"Giede","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0035","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jnci\/djj019","article-title":"Effect of surgeon specialty on processes of care and outcomes for ovarian cancer patients","volume":"98","author":"Earle","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0040","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejca.2005.09.029","article-title":"Surgical treatment of ovarian cancer in different hospital categories\u2014a prospective nation-wide study in Finland","volume":"42","author":"Kumpulainen","year":"2006","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.ygyno.2012.07.106_bb0045","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1600-0412.2012.01359.x","article-title":"From the Danish \u2018pelvic mass\u2019 ovarian cancer study","volume":"91","author":"H\u00e5kansson","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0050","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ygyno.2009.11.014","article-title":"Evaluation of the risk of malignancy index in daily clinical management of adnexal masses","volume":"116","author":"Van den Akker","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0055","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1525-1438.2005.00130.x","article-title":"CA125 in ovarian cancer: European group on tumor markers guidelines for clinical use","volume":"15","author":"Duffy","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0060","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ygyno.2005.06.040","article-title":"Potential markers that complement expression of CA125 in epithelial ovarian cancer","volume":"99","author":"Rosen","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0065","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstrom","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0070","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ygyno.2007.10.017","article-title":"The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass","volume":"108","author":"Moore","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1470-2045(06)70579-4","article-title":"Proteins with whey-acidic-protein motifs and cancer","volume":"7","author":"Bouchard","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0080","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-04-3924","article-title":"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas","volume":"65","author":"Drapkin","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0085","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.bjc.6606092","article-title":"HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the risk of ovarian malignancy algorithm","volume":"104","author":"Van","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0090","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","article-title":"Comprehensive analysis of HE4 expression in normal and malignant human tissues","volume":"19","author":"Galgano","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2008.08.031","article-title":"A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass","volume":"112","author":"Moore","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1515\/CCLM.2011.075","article-title":"The ROMA (risk of ovarian malignancy algorithm) for estimating the risk of epithelial ovarian cancer in women presenting with pelvic mass: is it really useful?","volume":"49","author":"Montagnana","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0105","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ajog.2010.03.043","article-title":"Comparison of a novel multiple marker assay vs the risk of malignancy index for the prediction of epithelial ovarian cancer in patients with a pelvic mass","volume":"203","author":"Moore","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ygyno.2012.07.106_bb0110","doi-asserted-by":"crossref","first-page":"358.e1","DOI":"10.1016\/j.ajog.2011.05.017","article-title":"Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women","volume":"205","author":"Holcomb","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0115","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.bjc.6605011","article-title":"Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts","volume":"100","author":"Huhtinen","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0120","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.bjc.6605119","article-title":"Usefulness of serum HE4 in endometriotic cysts","volume":"101","author":"Montagnana","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0125","author":"Fujirebio Diagnostics"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0130","author":"Abbott Diagnostics"},{"key":"10.1016\/j.ygyno.2012.07.106_bb0135","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.ejca.2011.12.003","article-title":"Subjective assessment by ultrasound is superior to the risk of malignancy index (RMI) or the risk of ovarian malignancy algorithm (ROMA) in discriminating benign from malignant adnexal masses","volume":"48","author":"Van Gorp","year":"2012","journal-title":"Eur J Cancer"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825812006270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825812006270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T12:19:56Z","timestamp":1561983596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825812006270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0090825812006270"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2012.07.106","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}