{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:23:53Z","timestamp":1791199433890,"version":"4.2.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.ygyno.2014.03.556","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T21:03:10Z","timestamp":1395522190000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":194,"title":["Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer"],"prefix":"10.1016","volume":"134","author":[{"given":"Jun-jun","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-chi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-xin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-qin","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2014.03.556_bb0005","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0010","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2644","article-title":"The biology of ovarian cancer: new opportunities for translation","volume":"9","author":"Bast","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0015","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc2946","article-title":"The genesis and evolution of high-grade serous ovarian cancer","volume":"10","author":"Bowtell","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0020","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(11)60126-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer","volume":"377","author":"Rustin","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0025","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1101\/gad.1800909","article-title":"Long noncoding RNAs: functional surprises from the RNA world","volume":"23","author":"Wilusz","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0030","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cell.2011.03.014","article-title":"No-nonsense functions for long noncoding RNAs","volume":"145","author":"Nagano","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0035","doi-asserted-by":"crossref","first-page":"e845","DOI":"10.1371\/journal.pone.0000845","article-title":"The H19 non-coding RNA is essential for human tumor growth","volume":"2","author":"Matouk","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0040","doi-asserted-by":"crossref","first-page":"26302","DOI":"10.1074\/jbc.M112.342113","article-title":"Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18","volume":"287","author":"Du","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","article-title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0050","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-12-0008","article-title":"MEG3 noncoding RNA: a tumor suppressor","volume":"48","author":"Zhou","year":"2012","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0055","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.onc.1209846","article-title":"A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas","volume":"26","author":"Lin","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0060","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/jnci\/djr416","article-title":"Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1","volume":"103","author":"Pasmant","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0065","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0070","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0075","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1245\/s10434-011-1581-y","article-title":"Overexpression of long noncoding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation","volume":"18","author":"Yang","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0080","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","article-title":"Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers","volume":"71","author":"Kogo","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0085","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2012.193","article-title":"HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer","volume":"32","author":"Kim","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0090","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1158\/0008-5472.CAN-11-1803","article-title":"Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors","volume":"72","author":"Niinuma","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0095","first-page":"57","article-title":"Expression of long non-coding RNA HOTAIR mRNA in ovarian cancer","volume":"44","author":"Cui","year":"2013","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0100","first-page":"891","article-title":"Enhanced c-erbB-2\/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A","volume":"53","author":"Yu","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/ijgc-00009577-200601000-00033","article-title":"Analysis of gene expression patterns of ovarian cancer cell lines with different metastatic potentials","volume":"16","author":"Bai","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1631\/jzus.B1000192","article-title":"Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior","volume":"12","author":"Wang","year":"2011","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0115","first-page":"233","article-title":"Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization","volume":"18","author":"Shenhua","year":"1999","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0120","doi-asserted-by":"crossref","first-page":"e46609","DOI":"10.1371\/journal.pone.0046609","article-title":"Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0125","first-page":"2949","article-title":"Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases","volume":"60","author":"Boissier","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0130","doi-asserted-by":"crossref","first-page":"e31251","DOI":"10.1371\/journal.pone.0031251","article-title":"Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0135","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11010-011-0909-z","article-title":"Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9","volume":"357","author":"Zhang","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0140","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1039\/c2mb25070e","article-title":"Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition","volume":"8","author":"Ying","year":"2012","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0145","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1016\/j.febslet.2010.10.008","article-title":"MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes","volume":"584","author":"Tano","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0150","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/carcin\/bgh228","article-title":"BC200 RNA in invasive and preinvasive breast cancer","volume":"25","author":"Iacoangeli","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0155","first-page":"5975","article-title":"DD3: a new prostate-specific gene, highly overexpressed in prostate cancer","volume":"9","author":"Bussemakers","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0160","doi-asserted-by":"crossref","first-page":"12216","DOI":"10.1073\/pnas.97.22.12216","article-title":"PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer","volume":"97","author":"Srikantan","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ygyno.2014.03.556_bb0165","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00109-013-1028-y","article-title":"MALAT1 \u2014 a paradigm for long noncoding RNA function in cancer","volume":"91","author":"Gutschner","year":"2013","journal-title":"J Mol Med (Berl)"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825814007987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825814007987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:35:08Z","timestamp":1758771308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825814007987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0090825814007987"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2014.03.556","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2014.03.556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}