{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:02:25Z","timestamp":1773378145202,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ygyno.2014.08.003","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T20:05:44Z","timestamp":1407528344000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Methylation marker analysis and HPV16\/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer"],"prefix":"10.1016","volume":"135","clinical-trial-number":[{"clinical-trial-number":"ntr6026","registry":"10.18810\/dutch-trial-register"}],"author":[{"given":"Viola M.J.","family":"Verhoef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00eblle A.M.","family":"Heideman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rozendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remko P.","family":"Bosgraaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albertus T.","family":"Hesselink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud L.M.","family":"Bekkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon F.A.G.","family":"Massuger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renske D.M.","family":"Steenbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.F.","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.L.M.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2014.08.003_bb0005","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.ejca.2009.07.018","article-title":"Trends of cervical cancer mortality in the member states of the European Union","volume":"45","author":"Arbyn","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0010","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(04)16674-9","article-title":"The cervical cancer epidemic that screening has prevented in the UK","volume":"364","author":"Peto","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0015","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/ijc.22114","article-title":"Nonattendance is still the main limitation for the effectiveness of screening for cervical cancer in the Netherlands","volume":"119","author":"Bos","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0020","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/ijc.27790","article-title":"High-risk HPV testing on self-sampled versus clinician-collected specimens: a review on the clinical accuracy and impact on population attendance in cervical cancer screening","volume":"132","author":"Snijders","year":"2013","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0025","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/jnci\/djr532","article-title":"Pooled analysis of a self-sampling HPV DNA Test as a cervical cancer primary screening method","volume":"104","author":"Zhao","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0030","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/S0140-6736(11)61522-5","article-title":"Self-collection of vaginal specimens for human papillomavirus testing in cervical cancer prevention (MARCH): a community-based randomised controlled trial","volume":"378","author":"Lazcano-Ponce","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0035","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S1470-2045(08)70210-9","article-title":"A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China","volume":"9","author":"Qiao","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0040","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1470-2045(13)70570-9","article-title":"Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis","volume":"15","author":"Arbyn","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0045","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","article-title":"Overview of the European and North American studies on HPV testing in primary cervical cancer screening","volume":"119","author":"Cuzick","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0050","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/jnci\/djn065","article-title":"Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test","volume":"100","author":"Ronco","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0055","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ijc.26056","article-title":"Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screening","volume":"130","author":"Rijkaart","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0060","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S1470-2045(11)70188-7","article-title":"Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25years and older: a subanalysis of the ATHENA study","volume":"12","author":"Castle","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0065","first-page":"266","article-title":"Cross-sectional study of patient- and physician-collected cervical cytology and human papillomavirus","volume":"102","author":"Garcia","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0070","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1128\/JCM.02440-05","article-title":"High concordance of results of testing for human papillomavirus in cervicovaginal samples collected by two methods, with comparison of a novel self-sampling device to a conventional endocervical brush","volume":"44","author":"Brink","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0075","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/jnci\/dji187","article-title":"The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice","volume":"97","author":"Khan","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0080","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ajog.2011.07.024","article-title":"The ATHENA human papillomavirus study: design, methods, and baseline results","volume":"206","author":"Wright","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0085","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ijc.28723","article-title":"Methylation marker analysis of self-sampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy","volume":"135","author":"Hesselink","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0090","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","article-title":"The causal relation between human papillomavirus and cervical cancer","volume":"55","author":"Bosch","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0095","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0100","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1158\/1078-0432.CCR-10-2548","article-title":"Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women","volume":"17","author":"Hesselink","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ygyno.2008.10.012","article-title":"Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science","volume":"112","author":"Wentzensen","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0110","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/ijc.26326","article-title":"A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients","volume":"130","author":"Eijsink","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0115","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ijc.25890","article-title":"Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women","volume":"129","author":"Overmeer","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0120","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/ijc.28138","article-title":"CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease","volume":"133","author":"Bierkens","year":"2013","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0125","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ygyno.2010.10.029","article-title":"Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study","volume":"120","author":"Eijsink","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1470-2045(14)70019-1","article-title":"Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial","volume":"15","author":"Verhoef","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6874-13-21","article-title":"A second generation cervico-vaginal lavage device shows similar performance as its preceding version with respect to DNA yield and HPV DNA results","volume":"13","author":"Verhoef","year":"2013","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0140","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/jcp.2003.011841","article-title":"The Dutch CISOE-A framework for cytology reporting increases efficacy of screening upon standardisation since 1996","volume":"57","author":"Bulk","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1470-2045(11)70296-0","article-title":"Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial","volume":"13","author":"Rijkaart","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0150","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie","year":"2007","journal-title":"Cell Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0155","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JCM.44.2.504-512.2006","article-title":"Bead-based multiplex genotyping of human papillomaviruses","volume":"44","author":"Schmitt","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1476-4598-9-167","article-title":"Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer","volume":"9","author":"Wilting","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1158\/1055-9965.EPI-13-0173","article-title":"Primary hrHPV DNA testing in Cervical Cancer screening: how to manage screen positive women? A POBASCAM Trial sub study","volume":"23","author":"Dijkstra","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0170","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","article-title":"Overview of the European and North American studies on HPV testing in primary cervical cancer screening","volume":"119","author":"Cuzick","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0175","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1470-2045(11)70296-0","article-title":"Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial","volume":"13","author":"Rijkaart","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.29026","article-title":"Comparative performance of novel self-sampling methods in detecting high-risk human papillomavirus in 30,130 women not attending cervical screening","author":"Bosgraaf","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ygyno.2014.08.003_bb0185","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.ejca.2011.11.022","article-title":"Offering self-sampling for human papillomavirus testing to non-attendees of the cervical screening programme: characteristics of the responders","volume":"48","author":"Gok","year":"2011","journal-title":"Eur J Cancer"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825814012554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825814012554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T18:44:11Z","timestamp":1565721851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825814012554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0090825814012554"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2014.08.003","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylation marker analysis and HPV16\/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2014.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}