{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:07:00Z","timestamp":1789945620347,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.ygyno.2015.01.537","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T01:18:07Z","timestamp":1421975887000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Hereditary predisposition to ovarian cancer, looking beyond BRCA1\/BRCA2"],"prefix":"10.1016","volume":"137","author":[{"given":"Lindsey E.","family":"Minion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill S.","family":"Dolinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana M.","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Monk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.ygyno.2015.01.537_bb0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrclinonc.2013.5","article-title":"Latest research and treatment of advanced-stage epithelial ovarian cancer","volume":"10","author":"Coleman","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"21","key":"10.1016\/j.ygyno.2015.01.537_bb0015","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa020119","article-title":"Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation","volume":"346","author":"Kauff","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.ygyno.2015.01.537_bb0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/jnci\/djn442","article-title":"Meta-analysis of risk reduction estimates associated with risk-reduction salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers","volume":"101","author":"Rebbeck","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.ygyno.2015.01.537_bb0025","doi-asserted-by":"crossref","first-page":"362","DOI":"10.7326\/0003-4819-143-5-200509060-00012","article-title":"Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: systematic evidence review for the U.S. Preventive Services Task Force","volume":"143","author":"Nelson","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ygyno.2015.01.537_bb0030","author":"American Cancer Society"},{"issue":"4","key":"10.1016\/j.ygyno.2015.01.537_bb0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/PPO.0b013e31826246c2","article-title":"Genetic testing by cancer site ovary","volume":"18","author":"Weisman","year":"2012","journal-title":"Cancer J."},{"issue":"2","key":"10.1016\/j.ygyno.2015.01.537_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s13402-011-0010-3","article-title":"Pathology of hereditary breast cancer","volume":"34","author":"Van der Groep","year":"2011","journal-title":"Cell. Oncol."},{"issue":"5182","key":"10.1016\/j.ygyno.2015.01.537_bb0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"issue":"6559","key":"10.1016\/j.ygyno.2015.01.537_bb0050","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2015.01.537_bb0055","author":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology"},{"issue":"5","key":"10.1016\/j.ygyno.2015.01.537_bb0060","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risk of breast and ovarian cancer associated with BRCA1 and BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.ygyno.2015.01.537_bb0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10689-013-9664-5","article-title":"Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention","volume":"12","author":"Lu","year":"2013","journal-title":"Fam. Cancer"},{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/hmg\/6.1.105","article-title":"Cancer risk associated with germline DNA mismatch repair gene mutations","volume":"6","author":"Dunlop","year":"1997","journal-title":"Hum. Mol. Genet."},{"issue":"44","key":"10.1016\/j.ygyno.2015.01.537_bb0075","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1073\/pnas.1115052108","article-title":"Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing","volume":"108","author":"Walsh","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.ygyno.2015.01.537_bb0080","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/ng.569","article-title":"Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene","volume":"42","author":"Meindl","year":"2010","journal-title":"Nat. Genet."},{"issue":"19","key":"10.1016\/j.ygyno.2015.01.537_bb0085","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1200\/JCO.2013.53.6607","article-title":"Clinical evaluation of multiple-gene sequencing panel for hereditary cancer risk assessment","volume":"32","author":"Kurian","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"11","key":"10.1016\/j.ygyno.2015.01.537_bb0090","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ng.955","article-title":"Mutations in BRIP1 confer high risk of ovarian cancer","volume":"43","author":"Rafnar","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.ygyno.2015.01.537_bb0095","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jama.295.12.1379","article-title":"Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer","volume":"295","author":"Walsh","year":"2006","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ygyno.2015.01.537_bb0100","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1399-0004.2012.01917.x","article-title":"Germline RAD51C mutations in ovarian cancer susceptibility","volume":"83","author":"Coulet","year":"2013","journal-title":"Clin. Genet."},{"issue":"3","key":"10.1016\/j.ygyno.2015.01.537_bb0105","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/bcr3669","article-title":"Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case\u2013control mutation-screening study","volume":"16","author":"Damiola","year":"2014","journal-title":"Breast Cancer Res."},{"issue":"20","key":"10.1016\/j.ygyno.2015.01.537_bb0110","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMra0809889","article-title":"Susceptibility pathways in Fanconi's anemia and breast cancer","volume":"362","author":"D'Andrea","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.ygyno.2015.01.537_bb0115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa1400382","article-title":"Breast-cancer risk in families with mutations in PALB2","volume":"371","author":"Antoniou","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0120","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/bcr2832","article-title":"Screening for BRCA1, BRCA2, CHEK2, PLAB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1\/2-founder mutations-negative breast and\/or ovarian cancer individuals","volume":"13","author":"Kuusisto","year":"2011","journal-title":"Breast Cancer Res."},{"issue":"12","key":"10.1016\/j.ygyno.2015.01.537_bb0125","first-page":"3325","article-title":"Contributions of ATM mutations to familial breast and ovarian cancer","volume":"63","author":"Thorstenson","year":"2003","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.ygyno.2015.01.537_bb0130","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/1078-0432.CCR-13-2287","article-title":"Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas","volume":"20","author":"Pennington","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.ygyno.2015.01.537_bb0135","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1158\/0008-5472.CAN-10-3958","article-title":"Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer","volume":"71","author":"Casadei","year":"2011","journal-title":"Cancer Res."},{"issue":"16","key":"10.1016\/j.ygyno.2015.01.537_bb0140","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1093\/hmg\/ddr229","article-title":"RAD51C is a susceptibility gene for ovarian cancer","volume":"20","author":"Pelttari","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.ygyno.2015.01.537_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygyno.2011.12.415","article-title":"Hereditary ovarian cancer: beyond the usual suspects","volume":"124","author":"Pennington","year":"2012","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0150","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ygyno.2004.07.015","article-title":"Analysis of CHEK2 gene for ovarian cancer susceptibility","volume":"95","author":"Baysal","year":"2004","journal-title":"Gynecol. Oncol."},{"issue":"11","key":"10.1016\/j.ygyno.2015.01.537_bb0155","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ejhg.2014.16","article-title":"Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes","volume":"22","author":"Castera","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2015.01.537_bb0160","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1038\/ncomms4156","article-title":"Integrated analysis of germline and somatic variants in ovarian cancer","volume":"5","author":"Kanchi","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc970","article-title":"The Fanconi anaemia\/BRCA pathway","volume":"3","author":"D'Andrea","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.ygyno.2015.01.537_bb0170","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/GIM.0b013e31816b5cae","article-title":"ACMG recommendations for standards for interpretation and reporting of sequence variations: revisions 2007","volume":"10","author":"Richards","year":"2008","journal-title":"Genet. Med."},{"key":"10.1016\/j.ygyno.2015.01.537_bb0175","article-title":"Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients","volume":"24","author":"LaDuca","year":"2014","journal-title":"Genet. Med."},{"issue":"34","key":"10.1016\/j.ygyno.2015.01.537_bb0180","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1200\/JCO.2008.16.1703","article-title":"\u201cBRCA\u201d syndrome in ovarian cancer: a case\u2013control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations","volume":"26","author":"Tan","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2015.01.537_bb0185","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/1078-0432.CCR-13-2287","article-title":"Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube and peritoneal carcinomas","volume":"20","author":"Pennington","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.ygyno.2015.01.537_bb0190","doi-asserted-by":"crossref","first-page":"e97408","DOI":"10.1371\/journal.pone.0097408","article-title":"The validation and clinical implementation of BRCAplus: a comprehensive high-risk breast cancer assay","volume":"9","author":"Chong","year":"2014","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.ygyno.2015.01.537_bb0195","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1200\/JCO.2009.27.5719","article-title":"Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer","volume":"28","author":"Konstantinopoulos","year":"2010","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2015.01.537_bb0200","doi-asserted-by":"crossref","first-page":"e30042","DOI":"10.1371\/journal.pone.0030042","article-title":"BRCAness profile of sporadic ovarian cancer predicts disease recurrence","volume":"7","author":"Wysham","year":"2012","journal-title":"PLoS One"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825815005417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825815005417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T21:16:09Z","timestamp":1566249369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825815005417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0090825815005417"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2015.01.537","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hereditary predisposition to ovarian cancer, looking beyond BRCA1\/BRCA2","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2015.01.537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}