{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:42:28Z","timestamp":1767998548132,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ygyno.2015.08.006","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T14:07:44Z","timestamp":1439906864000},"page":"211-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Rescreening for genetic mutations using multi-gene panel testing in patients who previously underwent non-informative genetic screening"],"prefix":"10.1016","volume":"139","author":[{"given":"Melissa K.","family":"Frey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Yee","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Martineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yi","family":"Chern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie V.","family":"Blank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ygyno.2015.08.006_bb0005","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/gim.2014.56","article-title":"Panel testing for inherited susceptibility to breast, ovarian, and colorectal cancer","volume":"16","author":"Domchek","year":"2014","journal-title":"Genet. Med."},{"issue":"2","key":"10.1016\/j.ygyno.2015.08.006_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ygyno.2015.02.017","article-title":"Two decades beyond BRCA1\/2: homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy","volume":"137","author":"Walsh","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2015.08.006_bb0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ygyno.2015.01.537","article-title":"Hereditary predisposition to ovarian cancer, looking beyond BRCA1\/BRCA2","volume":"137","author":"Minion","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0020","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1073\/pnas.1115052108","article-title":"Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing","volume":"108","author":"Walsh","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygyno.2011.12.415","article-title":"Hereditary ovarian cancer: beyond the usual suspects","volume":"124","author":"Pennington","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2015.08.006_bb0040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2015.08.006_bb0045","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0050","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1200\/JCO.2011.39.8545","article-title":"BRCA mutation frequency and patterns of treatment response in BRCA mutation\u2013positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group","volume":"30","author":"Alsop","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0055","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1200\/JCO.2014.57.1414","article-title":"Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer","volume":"33","author":"Couch","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0060","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ng.955","article-title":"Mutations in BRIP1 confer high risk of ovarian cancer","volume":"43","author":"Rafnar","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0065","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ng.893","article-title":"Germline mutations in RAD51D confer susceptibility to ovarian cancer","volume":"43","author":"Loveday","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ygyno.2012.09.009","article-title":"Loss of function germline mutations in RAD51D in women with ovarian carcinoma","volume":"127","author":"Wickramanayake","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0075","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1080\/09553009414552011","article-title":"Cancer risks in A-T heterozygotes","volume":"66","author":"Easton","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0080","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/jnci\/dji141","article-title":"Cancer risks and mortality in heterozygous ATM mutation carriers","volume":"97","author":"Thompson","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0085","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2014.01.022","article-title":"Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer","volume":"146","author":"Win","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ygyno.2015.08.006_bb0090","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/cncr.26506","article-title":"MutYH mutation carriers have increased breast cancer risk","volume":"118","author":"Rennert","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2015.08.006_bb0095","first-page":"5480","article-title":"The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast\u2013ovarian cancer kindreds","volume":"57","author":"Petrukhin","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/GIM.0b013e318207f564","article-title":"Genetic testing and cancer risk management recommendations by physicians for at-risk relatives","volume":"13","author":"Plon","year":"2011","journal-title":"Genet. Med."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0105","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/bcr2223","article-title":"A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history","volume":"11","author":"Gomez Garcia","year":"2009","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10897-007-9090-7","article-title":"Risk assessment and genetic counseling for hereditary breast and ovarian cancer: recommendations of the National Society of Genetic Counselors","volume":"16","author":"Berliner","year":"2007","journal-title":"J. Genet. Couns."},{"key":"10.1016\/j.ygyno.2015.08.006_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/cge.12315","article-title":"A comprehensive laboratory-based program for classification of variants of uncertain significance in hereditary cancer genes","volume":"86","author":"Eggington","year":"2014","journal-title":"Clin. Genet."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825815301013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825815301013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T01:27:25Z","timestamp":1537406845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825815301013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0090825815301013"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2015.08.006","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rescreening for genetic mutations using multi-gene panel testing in patients who previously underwent non-informative genetic screening","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2015.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}