{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:08:27Z","timestamp":1793254107499,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/112.070\/2012"],"award-info":[{"award-number":["E-26\/112.070\/2012"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ygyno.2017.09.007","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T07:30:48Z","timestamp":1505806248000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Does hormonal contraception during molar pregnancy follow-up influence the risk and clinical aggressiveness of gestational trophoblastic neoplasia after controlling for risk factors?"],"prefix":"10.1016","volume":"147","author":[{"given":"Patr\u00edcia Rangel Sobral","family":"Dantas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izildinha","family":"Maest\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Rezende","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joffre Amin","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Howoritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6182","authenticated-orcid":false,"given":"Antonio","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross S.","family":"Berkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2017.09.007_bb0005","first-page":"241","article-title":"Epidemiological report on the treatment of patients with gestational trophoblastic disease in 10 Brazilian referral centers: results after 12years since International FIGO 2000 Consensus","volume":"59","author":"Braga","year":"2014","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"Suppl. 6","key":"10.1016\/j.ygyno.2017.09.007_bb0015","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1093\/annonc\/mdt345","article-title":"Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Seckl","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ygyno.2012.07.116","article-title":"Current advances in the management of gestational trophoblastic disease","volume":"128","author":"Berkowitz","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0020-7292(02)00063-2","article-title":"FIGO staging for gestational trophoblastic neoplasia 2000","volume":"77","author":"F\u00e9d\u00e9ration Internationale de Gyn\u00e9cologie et d'Obst\u00e9trique Oncology Committee","year":"2002","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0030","first-page":"145","article-title":"Worldwide survey of the results of treating gestational trophoblastic disease","volume":"59","author":"Kohorn","year":"2014","journal-title":"J. Reprod. Med."},{"issue":"9 Suppl 3","key":"10.1016\/j.ygyno.2017.09.007_bb0035","doi-asserted-by":"crossref","first-page":"109S","DOI":"10.1097\/IGC.0000000000000294","article-title":"Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup","volume":"24","author":"Mangili","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0040","first-page":"3","article-title":"Diagnosis, classification and treatment of gestational trophoblastic neoplasia","volume":"128","author":"Biscaro","year":"2013","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0045","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ygyno.2008.10.027","article-title":"Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women","volume":"112","author":"Braga","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0050","series-title":"Medical Eligibility Criteria for Contraceptive Use","author":"World Health Organization (WHO)","year":"2015"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0055","author":"Royal College of Obstetricians and Gynaecologists (RCOG)"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0060","author":"Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG)"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0065","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-0528.1976.tb00774.x","article-title":"Relationship of oral contraception to development of trophoblastic tumor after evacuation of a hydatidiform mole","volume":"83","author":"Stone","year":"1976","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0070","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1471-0528.1979.tb10694.x","article-title":"An analysis of the influences of maternal age, gestational age, contraceptive method, and the mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy","volume":"86","author":"Stone","year":"1979","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0075","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0140-6736(80)92510-6","article-title":"Oral contraceptives and post-molar trophoblastic tumours","volume":"2","author":"Bagshawe","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0080","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ygyno.2005.09.031","article-title":"Influence of oral contraceptives in the development of postmolar trophoblastic neoplasia - a systematic review","volume":"100","author":"Costa","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0085","first-page":"474","article-title":"Oral contraceptives and postmolar trophoblastic disease","volume":"58","author":"Berkowitz","year":"1981","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0090","first-page":"736","article-title":"Postmolar trophoblastic disease in women using hormonal contraception with and without estrogen","volume":"62","author":"Eddy","year":"1983","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0095","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/0002-9378(85)90669-6","article-title":"The influence of oral contraceptives on the postmolar human chorionic gonadotropin regression curve","volume":"151","author":"Morrow","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0100","first-page":"221","article-title":"The role of contraception in the development of postmolar trophoblastic tumor","volume":"78","author":"Deicas","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0105","series-title":"Comparison on the Need for Chemotherapy of the Hydatidiform Mole Patients Who Are Using Oral Contraceptives and Patients Who Are Not","first-page":"590","author":"Utoro","year":"1992"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1471-0528.1987.tb02246.x","article-title":"Medroxyprogesterone acetate in non-metastatic gestational trophoblastic disease","volume":"94","author":"Goldberg","year":"1987","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0002-9378(83)90494-5","article-title":"Relationship of oral contraceptives and the intrauterine contraceptive devices to the regression of concentration of the beta subunit of human chorionic gonadotropin and invasive complications after molar pregnancy","volume":"145","author":"Yuen","year":"1983","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0120","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0002-9378(89)90295-0","article-title":"Hormonal contraception and trophoblastic sequelae after hydatidiform mole (a Gynecologic Oncology Group study)","volume":"160","author":"Curry","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01443610063516","article-title":"Fertility regulatory methods and development of complications after evacuation of complete hydatidiform mole","volume":"20","author":"Adewole","year":"2000","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.contraception.2009.03.022","article-title":"Combined oral contraceptive and intrauterine device use among women with gestational trophoblastic disease","volume":"80","author":"Gaffield","year":"2009","journal-title":"Contraception"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0135","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/1471-0528.13617","article-title":"Hormonal contraceptive use before hCG remission does not increase the risk of gestational trophoblastic neoplasia following complete hydatidiform mole: a historical database review","volume":"123","author":"Braga","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15513810903266138","article-title":"Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications","volume":"29","author":"Sebire","year":"2010","journal-title":"Fetal Pediatr. Pathol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0145","first-page":"793","article-title":"The need for an hCG assay that appropriately detects trophoblastic disease and other hCG-producing cancers","volume":"51","author":"Cole","year":"2006","journal-title":"J. Reprod. Med."},{"issue":"5","key":"10.1016\/j.ygyno.2017.09.007_bb0150","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/IGC.0000000000000682","article-title":"Changing trends in the clinical presentation and management of complete hydatidiform mole among Brazilian women","volume":"26","author":"Braga","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2017.09.007_bb0155","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMcp0900696","article-title":"Clinical practice. Molar pregnancy","volume":"360","author":"Berkowitz","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0160","first-page":"254","article-title":"Complete hydatidiform mole in women aged 40 to 49years","volume":"57","author":"Elias","year":"2012","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0165","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ygyno.2016.01.005","article-title":"The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy","volume":"140","author":"Gockley","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0170","first-page":"940","article-title":"Poor compliance with postmolar surveillance and treatment protocols by indigent women","volume":"96","author":"Massad","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0175","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1067\/mob.2003.297","article-title":"Postmolar surveillance at a trophoblastic disease center that serves indigent women","volume":"188","author":"Allen","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ygyno.2005.12.048","article-title":"Gestational trophoblastic diseases: 4. Presentation with persistent low positive human chorionic gonadotropin test results","volume":"102","author":"Cole","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0185","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1373\/clinchem.2005.053595","article-title":"Diagnostic considerations in the measurement of human chorionic gonadotropin in aging women","volume":"51","author":"Snyder","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ygyno.2017.09.007_bb0190","first-page":"419","article-title":"Ageing and the glomerular filtration rate: truths and consequences","volume":"120","author":"Glassock","year":"2009","journal-title":"Trans. Am. Clin. Climatol. Assoc."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825817313100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825817313100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T09:37:40Z","timestamp":1583919460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825817313100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0090825817313100"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2017.09.007","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does hormonal contraception during molar pregnancy follow-up influence the risk and clinical aggressiveness of gestational trophoblastic neoplasia after controlling for risk factors?","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2017.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}