{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:30:07Z","timestamp":1787164207468,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["IKNL2014-6838"],"award-info":[{"award-number":["IKNL2014-6838"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ygyno.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T09:27:10Z","timestamp":1531128430000},"page":"446-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Interval between debulking surgery and adjuvant chemotherapy is associated with overall survival in patients with advanced ovarian cancer"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-8328","authenticated-orcid":false,"given":"M.","family":"Timmermans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"van der Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.I.","family":"Lalisang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.O.","family":"Witteveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Van de Vijver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.F.","family":"Kruitwagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"Sonke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2018.07.004_bb0005","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1200\/JCO.2016.68.6907","article-title":"Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: Society of Gynecologic Oncology and American Society of Clinical Oncology clinical practice guideline","volume":"34","author":"Wright","year":"2016","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0010","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ygyno.2013.05.040","article-title":"Survival impact of complete cytoreduction to no gross residual disease for advanced-stage ovarian cancer: a meta-analysis","volume":"130","author":"Chang","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(14)62223-6","article-title":"Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial","volume":"386","author":"Kehoe","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0020","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1056\/NEJMoa0908806","article-title":"Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer","volume":"363","author":"Vergote","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/imj.13190","article-title":"Timely initiation of chemotherapy: a systematic literature review of six priority cancers - results and recommendations for clinical practice","volume":"47","author":"Alexander","year":"2017","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0030","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/gyno.2002.6750","article-title":"Does the interval from primary surgery to chemotherapy influence progression-free survival in ovarian cancer?","volume":"86","author":"Flynn","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejca.2012.07.023","article-title":"Prognostic impact of the time interval between surgery and chemotherapy in advanced ovarian cancer: analysis of prospective randomised phase III trials","volume":"49","author":"Mahner","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0040","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1200\/JCO.2013.49.7693","article-title":"Clinical impact of delaying initiation of adjuvant chemotherapy in patients with breast cancer","volume":"32","author":"Gagliato Dde","year":"2014","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0045","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s12032-010-9566-4","article-title":"Optimal timing of adjuvant treatment in patients with early breast cancer","volume":"28","author":"Alkis","year":"2011","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0050","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ejca.2010.01.020","article-title":"Does delaying adjuvant chemotherapy after curative surgery for colorectal cancer impair survival? A meta-analysis","volume":"46","author":"Des Guetz","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0055","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.ejca.2015.08.016","article-title":"Timing of adjuvant chemotherapy and its relation to survival among patients with stage III colon cancer","volume":"51","author":"Bos","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/00016340902814559","article-title":"Epithelial ovarian cancer: does the time interval between primary surgery and postoperative chemotherapy have any prognostic importance?","volume":"88","author":"Larsen","year":"2009","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0065","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1200\/JCO.2005.03.065","article-title":"Relationship between time interval from primary surgery to the start of taxane-plus platinum-based chemotherapy and clinical outcome of patients with advanced epithelial ovarian cancer: results of a multicenter retrospective Italian study","volume":"23","author":"Gadducci","year":"2005","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ygyno.2006.01.035","article-title":"Influence of interval between primary surgery and chemotherapy on short-term survival of patients with advanced ovarian, tubal or peritoneal cancer","volume":"102","author":"Paulsen","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ygyno.2006.07.045","article-title":"Is time to chemotherapy a determinant of prognosis in advanced-stage ovarian cancer?","volume":"104","author":"Aletti","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0080","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/0284186X.2015.1054950","article-title":"Variations in adjuvant chemotherapy and survival in women with epithelial ovarian cancer - a population-based study","volume":"55","author":"Anuradha","year":"2016","journal-title":"Acta Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0085","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ejso.2006.02.013","article-title":"The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma","volume":"32","author":"Rosa","year":"2006","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0090","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ygyno.2014.04.004","article-title":"Is it possible to define an optimal time for chemotherapy after surgery for ovarian cancer?","volume":"133","author":"Lydiksen","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0095","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1048-891X.2004.014509.x","article-title":"Prognostic importance of the time interval from surgery to chemotherapy in treatment of ovarian carcinoma","volume":"14","author":"Sorbe","year":"2004","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2013.07.086","article-title":"The time interval from surgery to start of chemotherapy significantly impacts prognosis in patients with advanced serous ovarian carcinoma - analysis of patient data in the prospective OVCAD study","volume":"131","author":"Hofstetter","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0105","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/sj.bjc.6604298","article-title":"Variability in chemotherapy delivery for elderly women with advanced stage ovarian cancer and its impact on survival","volume":"98","author":"Wright","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/annonc\/mdv500","article-title":"Early initiation of chemotherapy following complete resection of advanced ovarian cancer associated with improved survival: NRG Oncology\/Gynecologic Oncology Group study","volume":"27","author":"Tewari","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0115","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/AOG.0b013e31826981de","article-title":"Effect of radical cytoreductive surgery on omission and delay of chemotherapy for advanced-stage ovarian cancer","volume":"120","author":"Wright","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ygyno.2016.09.004","article-title":"Preoperative predictors of delay in initiation of adjuvant chemotherapy in patients undergoing primary debulking surgery for ovarian cancer","volume":"143","author":"Singh","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0125","series-title":"International Classification of Diseases for Oncology: ICD-O","author":"Fritz","year":"2000"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0135","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1002\/cncr.25537","article-title":"TNM seventh edition: what's new, what's changed: communication from the International Union Against Cancer and the American Joint Committee on Cancer","volume":"116","author":"Sobin","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0140","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/IGC.0000000000001001","article-title":"Ovarian cancer and comorbidity: is poor survival explained by choice of primary treatment or system delay?","volume":"27","author":"Noer","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2018.07.004_bb0145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ygyno.2015.05.034","article-title":"Predictive value of the Age-Adjusted Charlson Comorbidity Index on perioperative complications and survival in patients undergoing primary debulking surgery for advanced epithelial ovarian cancer","volume":"138","author":"Suidan","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0150","first-page":"1488","article-title":"Influence of the interval between primary tumor removal and chemotherapy on kinetics and growth of metastases","volume":"43","author":"Fisher","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0155","first-page":"3861","article-title":"Effect of surgical removal on the growth and kinetics of residual tumor","volume":"39","author":"Gunduz","year":"1979","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2018.07.004_bb0160","doi-asserted-by":"crossref","first-page":"13203","DOI":"10.1073\/pnas.94.24.13203","article-title":"Loss of ovarian function promotes angiogenesis in human ovarian carcinoma","volume":"94","author":"Schiffenbauer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825818310175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825818310175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T22:00:12Z","timestamp":1534802412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825818310175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0090825818310175"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2018.07.004","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interval between debulking surgery and adjuvant chemotherapy is associated with overall survival in patients with advanced ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2018.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}