{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:00:04Z","timestamp":1776254404273,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ygyno.2018.12.010","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T22:30:58Z","timestamp":1552429858000},"page":"522-527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evolving trends in the management of high-intermediate risk endometrial cancer in the United States"],"prefix":"10.1016","volume":"152","author":[{"given":"Sara J.","family":"Zakem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler P.","family":"Robin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-9159","authenticated-orcid":false,"given":"Arya","family":"Amini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Lefkowits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0090-8258(91)90086-K","article-title":"Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study","volume":"40","author":"Morrow","year":"1991","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0015","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ygyno.2003.11.048","article-title":"A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study","volume":"92","author":"Keys","year":"2004","journal-title":"Gynecol. Oncol."},{"issue":"9213","key":"10.1016\/j.ygyno.2018.12.010_bb0020","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/S0140-6736(00)02139-5","article-title":"Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma","volume":"355","author":"Creutzberg","year":"2000","journal-title":"Lancet"},{"issue":"9717","key":"10.1016\/j.ygyno.2018.12.010_bb0025","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(09)62163-2","article-title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial","volume":"375","author":"Nout","year":"2010","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ygyno.2018.12.010_bb0030","first-page":"999","article-title":"Pelvic radiation therapy for early endometrial cancer: careful selection is key","volume":"27","author":"Fisher","year":"2013","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.ygyno.2018.12.010_bb0035","series-title":"Pelvic Radiation Therapy Standard for Early Endometrial Cancer","author":"Samson","year":"2017"},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0040","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1245\/s10434-007-9747-3","article-title":"The National Cancer Data Base: a powerful initiative to improve cancer care in the United States","volume":"15","author":"Bilimoria","year":"2008","journal-title":"Ann. Surg. Oncol."},{"issue":"13","key":"10.1016\/j.ygyno.2018.12.010_bb0045","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.ejca.2015.05.015","article-title":"Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer\u2014a pooled analysis of PORTEC 1 and 2 trials","volume":"51","author":"Bosse","year":"2015","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.ygyno.2018.12.010_bb0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0090-8258(03)00087-8","article-title":"Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy","volume":"89","author":"Straughn","year":"2003","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0360-3016(90)90477-2","article-title":"Patterns of failure in patients with stage I, grade 3 carcinoma of the endometrium","volume":"19","author":"Greven","year":"1990","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ygyno.2018.12.010_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003916.pub2","article-title":"Adjuvant radiotherapy for stage I endometrial cancer","volume":"2","author":"Kong","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"issue":"21","key":"10.1016\/j.ygyno.2018.12.010_bb0065","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/jnci\/djs374","article-title":"Adjuvant radiotherapy for stage I endometrial cancer: an updated Cochrane systematic review and meta-analysis","volume":"104","author":"Kong","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"issue":"4","key":"10.1016\/j.ygyno.2018.12.010_bb0070","doi-asserted-by":"crossref","first-page":"e631","DOI":"10.1016\/j.ijrobp.2011.04.013","article-title":"Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma","volume":"81","author":"Creutzberg","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"5","key":"10.1016\/j.ygyno.2018.12.010_bb0075","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0360-3016(01)01765-5","article-title":"The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial","volume":"51","author":"Creutzberg","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"13","key":"10.1016\/j.ygyno.2018.12.010_bb0080","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1200\/JCO.2010.32.4590","article-title":"Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in endometrial carcinoma 1 (PORTEC-1) trial","volume":"29","author":"Nout","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2018.12.010_bb0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0360-3016(99)00427-7","article-title":"High-dose-rate postoperative vaginal cuff irradiation alone for stage IB and IC endometrial cancer","volume":"46","author":"Anderson","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijrobp.2004.09.054","article-title":"Intravaginal brachytherapy alone for intermediate-risk endometrial cancer","volume":"62","author":"Alektiar","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/gyno.1999.5526","article-title":"Patterns of failure in endometrial carcinoma stage IB grade 3 and IC patients treated with postoperative vaginal vault brachytherapy","volume":"75","author":"Chadha","year":"1999","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0100","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ygyno.2005.04.030","article-title":"Stage II endometrial carcinoma: limiting post-operative radiotherapy to the vaginal vault in node-negative tumors","volume":"98","author":"Rittenberg","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/gyno.1998.5155","article-title":"Adjuvant vaginal high-dose-rate afterloading alone in endometrial carcinoma: patterns of relapse and side effects following low-dose therapy","volume":"71","author":"Weiss","year":"1998","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2018.12.010_bb0110","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1111\/j.1525-1438.2008.01198.x","article-title":"Vaginal high dose rate brachytherapy alone in patients with intermediate- to high-risk stage I endometrial carcinoma after radical surgery","volume":"18","author":"Atahan","year":"2008","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0115","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ygyno.2009.06.027","article-title":"Adjuvant vaginal brachytherapy alone for high risk localized endometrial cancer as defined by the three major randomized trials of adjuvant pelvic radiation","volume":"116","author":"McCloskey","year":"2010","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2018.12.010_bb0120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijrobp.2011.12.010","article-title":"Clinical outcomes in international federation of gynecology and obstetrics stage IA endometrial cancer with myometrial invasion treated with or without postoperative vaginal brachytherapy","volume":"84","author":"Diavolitsis","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0125","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ygyno.2005.02.021","article-title":"Vaginal brachytherapy alone: an alternative to adjuvant whole pelvis radiation for early stage endometrial cancer","volume":"97","author":"Jolly","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0130","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijrobp.2011.05.052","article-title":"Trends in the utilization of adjuvant vaginal cuff brachytherapy and\/or external beam radiation treatment in stage I and II endometrial cancer: a surveillance, epidemiology, and end-results study","volume":"83","author":"Patel","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"5","key":"10.1016\/j.ygyno.2018.12.010_bb0135","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.brachy.2016.06.012","article-title":"Trends in the utilization of adjuvant vaginal brachytherapy in women with early-stage endometrial carcinoma: results of an updated period analysis of SEER data","volume":"15","author":"Modh","year":"2016","journal-title":"Brachytherapy"},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brachy.2016.09.010","article-title":"Patterns of care in women with high-intermediate risk endometrioid adenocarcinoma in the PORTEC-2 era: a SEER database analysis","volume":"16","author":"Zavitsanos","year":"2017","journal-title":"Brachytherapy"},{"issue":"3","key":"10.1016\/j.ygyno.2018.12.010_bb0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.prro.2014.01.003","article-title":"The role of postoperative radiation therapy for endometrial cancer: executive summary of an American Society for Radiation Oncology evidence-based guideline","volume":"4","author":"Klopp","year":"2014","journal-title":"Pract. Radiat. Oncol."},{"issue":"26","key":"10.1016\/j.ygyno.2018.12.010_bb0150","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1200\/JCO.2015.62.5459","article-title":"Postoperative radiation therapy for endometrial Cancer: American society of clinical oncology clinical practice guideline endorsement of the American society for radiation oncology evidence-based guideline","volume":"33","author":"Meyer","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2018.12.010_bb0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ygyno.2016.07.107","article-title":"Disparities in treatment and survival for women with endometrial cancer: a contemporary national cancer database registry analysis","volume":"143","author":"Fader","year":"2016","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2018.12.010_bb0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J. Clin. Epidemiol."},{"issue":"6","key":"10.1016\/j.ygyno.2018.12.010_bb0165","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1245\/s10434-013-2901-1","article-title":"Comparison of cases captured in the national cancer data base with those in population-based central cancer registries","volume":"20","author":"Lerro","year":"2013","journal-title":"Ann. Surg. Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825818314744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825818314744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T23:11:20Z","timestamp":1552432280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825818314744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0090825818314744"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2018.12.010","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolving trends in the management of high-intermediate risk endometrial cancer in the United States","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2018.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}