{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:24:08Z","timestamp":1766269448575,"version":"3.44.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Science and Technology Programs of Foshan","award":["2017AB002801"],"award-info":[{"award-number":["2017AB002801"]}]},{"name":"Medical Research Foundation of Guangdong Province, China","award":["B2018034"],"award-info":[{"award-number":["B2018034"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ygyno.2019.03.006","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T18:34:20Z","timestamp":1553193260000},"page":"661-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-4685","authenticated-orcid":false,"given":"Yutao","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2019.03.006_bb0005","first-page":"1622","article-title":"ClC-3 chloride channel modulates the proliferation and migration of osteosarcoma cells via AKT\/GSK3beta signaling pathway","volume":"8","author":"Du","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0010","doi-asserted-by":"crossref","unstructured":"Wang B, Xie J, He HY, Huang EW, Cao QH, Luo L, et al. Suppression of CLC-3 chloride channel reduces the aggressiveness of glioma through inhibiting nuclear factor-kappaB pathway. Oncotarget. 2017;8:63788\u201398.","DOI":"10.18632\/oncotarget.19093"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0015","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2147\/CMAR.S159790","article-title":"Overexpression of chloride channel-3 predicts unfavorable prognosis and promotes cellular invasion in gastric cancer","volume":"10","author":"Peng","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0020","doi-asserted-by":"crossref","unstructured":"Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, et al. Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-kappaB pathway. Hypertension. 2012;60:1287\u201393.","DOI":"10.1161\/HYPERTENSIONAHA.112.198648"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0025","doi-asserted-by":"crossref","unstructured":"Liu J, Zhang D, Li Y, Chen W, Ruan Z, Deng L, et al. Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities. J. Med. Chem.. 2013;56:5734\u201343.","DOI":"10.1021\/jm400881m"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0030","unstructured":"Wang F, Tan WH, Liu W, Jin YX, Dong DD, Zhao XJ, et al. Effects of miR-214 on cervical cancer cell proliferation, apoptosis and invasion via modulating PI3K\/AKT\/mTOR signal pathway. Eur. Rev. Med. Pharmacol. Sci. 2018;22:1891\u20138."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0035","doi-asserted-by":"crossref","first-page":"10707","DOI":"10.1007\/s13277-014-2386-y","article-title":"FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K\/AKT\/mTOR\/p70S6K signaling pathway","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0040","doi-asserted-by":"crossref","unstructured":"Guan YT, Huang YQ, Wu JB, Deng ZQ, Wang Y, Lai ZY, et al. Overexpression of chloride channel-3 is associated with the increased migration and invasion ability of ectopic endometrial cells from patients with endometriosis. Hum. Reprod.. 2016;31:986\u201398.","DOI":"10.1093\/humrep\/dew034"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0045","first-page":"6077","article-title":"Volume-sensitive chloride channels associated with human cervical carcinogenesis","volume":"55","author":"Chou","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0050","first-page":"689","article-title":"CLC-3 Cl\u2212 channel-mediated invasion and migration of human ovarian cancer cells","volume":"37","author":"Li","year":"2016","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0055","first-page":"60","article-title":"Effects of volume-activated chloride channels on the invasion and migration of human endometrial cancer cells","volume":"34","author":"Li","year":"2013","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0060","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3181\/0711-MR-308","article-title":"An unexpected role for ion channels in brain tumor metastasis","volume":"233","author":"Sontheimer","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/md15080238","article-title":"Sinulariolide suppresses cell migration and invasion by inhibiting matrix metalloproteinase-2\/-9 and urokinase through the PI3K\/AKT\/mTOR signaling pathway in human bladder cancer cells","volume":"15","author":"Cheng","year":"2017","journal-title":"Mar. Drugs"},{"issue":"7","key":"10.1016\/j.ygyno.2019.03.006_bb0070","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3727\/096504018X15166223632406","article-title":"Phosphoglycerate mutase 1 (PGAM1) promotes pancreatic ductal adenocarcinoma (PDAC) metastasis by acting as a novel downstream target of PI3K\/Akt\/mTOR pathway","volume":"26","author":"Liu","year":"2018","journal-title":"Oncol. Res."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0075","first-page":"3067","article-title":"LHX6 inhibits the proliferation, invasion and migration of breast cancer cells by modulating the PI3K\/Akt\/mTOR signaling pathway","volume":"22","author":"Bi","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0080","doi-asserted-by":"crossref","unstructured":"Neoh CA, Wu WT, Dai GF, Su JH, Liu CI, Su TR, et al. Flaccidoxide-13-acetate extracted from the soft coral Cladiella kashmani reduces human bladder cancer cell migration and invasion through reducing activation of the FAK\/PI3K\/AKT\/mTOR signaling pathway. Molecules. 2017;23.","DOI":"10.3390\/molecules23010058"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0085","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1210\/en.2012-2074","article-title":"TGF-beta effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K\/AKT\/mTOR pathway","volume":"154","author":"Vo","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0090","doi-asserted-by":"crossref","unstructured":"Bahrami A, Hasanzadeh M, Hassanian SM, ShahidSales S, Ghayour-Mobarhan M, Ferns GA, et al. The potential value of the PI3K\/Akt\/mTOR signaling pathway for assessing prognosis in cervical cancer and as a target for therapy. J. Cell. Biochem.. 2017;118:4163\u20139.","DOI":"10.1002\/jcb.26118"},{"issue":"9","key":"10.1016\/j.ygyno.2019.03.006_bb0095","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1111\/cas.13715","article-title":"Transcriptional repression of HER2 by ClC-3 Cl\u2212\/H+ transporter inhibition in human breast cancer cells","volume":"109","author":"Fujimoto","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0100","first-page":"2321","article-title":"MicroRNA-520a-3p inhibits cell growth and metastasis of non-small cell lung cancer through PI3K\/AKT\/mTOR signaling pathway","volume":"22","author":"Lv","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0105","doi-asserted-by":"crossref","unstructured":"Jiang Y, Zhang Q, Bao J, Du C, Wang J, Tong Q, et al. Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR\/MMP-9 signal pathway. Biomed. Pharmacother.. 2015;74:77\u201382.","DOI":"10.1016\/j.biopha.2015.07.006"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0110","doi-asserted-by":"crossref","unstructured":"Kou B, Liu W, He W, Zhang Y, Zheng J, Yan Y, et al. Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt\/mTOR\/MMP-9 signaling pathway. Oncol. Rep.. 2016;35:2880\u20136.","DOI":"10.3892\/or.2016.4649"},{"key":"10.1016\/j.ygyno.2019.03.006_bb0115","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.2147\/OTT.S175578","article-title":"(ZD6474) induces antiangiogenesis through mTOR-HIF-1 alpha-VEGF signaling axis in breast cancer cells","volume":"11","author":"Li","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.ygyno.2019.03.006_bb0120","first-page":"1160","article-title":"Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF1alpha pathway","volume":"53","author":"Kim","year":"2018","journal-title":"Int. J. Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825819301544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825819301544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:44:39Z","timestamp":1758771879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825819301544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0090825819301544"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2019.03.006","relation":{},"ISSN":["0090-8258"],"issn-type":[{"type":"print","value":"0090-8258"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2019.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}