{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:56:19Z","timestamp":1793357779483,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ygyno.2019.10.028","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T09:06:03Z","timestamp":1574154363000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer"],"prefix":"10.1016","volume":"156","author":[{"given":"Marina","family":"Stasenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Tunnage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia J.","family":"Latham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Da Cruz Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Mario M.","family":"Leitao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire F.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Makker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Soslow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah F.","family":"DeLair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitriy","family":"Zamarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaled M.","family":"Alektiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Aghajanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem R.","family":"Abu-Rustum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Weigelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Cadoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2019.10.028_bib1","first-page":"7","article-title":"Cancer statistics","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin 2019"},{"key":"10.1016\/j.ygyno.2019.10.028_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Cancer Genome Atlas Research Kandoth","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2019.10.028_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1126\/science.1144067","article-title":"Yeast DNA polymerase epsilon participates in leading-strand DNA replication","volume":"317","author":"Pursell","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2019.10.028_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.dnarep.2019.02.007","article-title":"POLE proofreading defects: contributions to mutagenesis and cancer","volume":"76","author":"Park","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.ygyno.2019.10.028_bib5","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1101\/gr.174789.114","article-title":"Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication","volume":"24","author":"Shinbrot","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.ygyno.2019.10.028_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/jnci\/dju402","article-title":"Prognostic significance of POLE proofreading mutations in endometrial cancer","volume":"107","author":"Church","year":"2015","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.ygyno.2019.10.028_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/cncr.29046","article-title":"Polymerase varepsilon (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing","volume":"121","author":"Billingsley","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.ygyno.2019.10.028_bib8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/PAS.0000000000001020","article-title":"Molecular classification of grade 3 endometrioid endometrial cancers identifies distinct prognostic subgroups","volume":"42","author":"Bosse","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib9","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/IGC.0000000000000681","article-title":"Prognostic significance of POLE exonuclease domain mutations in high-grade endometrioid endometrial cancer on survival and recurrence: a subanalysis","volume":"26","author":"Billingsley","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2019.10.028_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2014.05.006","article-title":"POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium","volume":"134","author":"Meng","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/path.5034","article-title":"The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses","volume":"244","author":"McAlpine","year":"2018","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm.4333","article-title":"Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients","volume":"23","author":"Zehir","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ygyno.2019.10.028_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial sloan Kettering-integrated mutation profiling of actionable cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology","volume":"17","author":"Cheng","year":"2015","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.ygyno.2019.10.028_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.2017.11137","article-title":"Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing","volume":"318","author":"Mandelker","year":"2017","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.ygyno.2019.10.028_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/gim.2016.190","article-title":"Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics","volume":"19","author":"Kalia","year":"2017","journal-title":"Genet. Med."},{"key":"10.1016\/j.ygyno.2019.10.028_bib16","doi-asserted-by":"crossref","first-page":"2820282","DOI":"10.1093\/hmg\/ddt131","article-title":"DNA polymerase epsilon and delta exonuclease domain mutations in endometrial cancer","volume":"22","author":"Church","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ygyno.2019.10.028_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1158\/2159-8290.CD-17-0321","article-title":"Accelerating discovery of functional mutant alleles in cancer","volume":"8","author":"Chang","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ygyno.2019.10.028_bib18","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ygyno.2019.10.028_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ygyno.2018.10.032","article-title":"Analysis of mutational signatures in primary and metastatic endometrial cancer reveals distinct patterns of DNA repair defects and shifts during tumor progression","volume":"152","author":"Ashley","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib20","article-title":"Reliable pan-cancer microsatellite instability assessment by using targeted next-generation sequencing data","volume":"2017","author":"Middha","year":"2017","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.ygyno.2019.10.028_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/bioinformatics\/btt755","article-title":"MSIsensor: microsatellite instability detection using paired tumor-normal sequence data","volume":"30","author":"Niu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygyno.2019.10.028_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/01.pas.0000213428.61374.06","article-title":"Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma","volume":"31","author":"Modica","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib23","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1158\/1078-0432.CCR-07-1849","article-title":"Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients","volume":"14","author":"Walsh","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2019.10.028_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2019.10.028_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13059-016-0893-4","article-title":"DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution","volume":"17","author":"Rosenthal","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib26","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1158\/1078-0432.CCR-15-2233","article-title":"Endometrial carcinomas with POLE exonuclease domain mutations have a favorable prognosis","volume":"22","author":"McConechy","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2019.10.028_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gore.2018.10.010","article-title":"Brain metastases in patients with low-grade endometrial carcinoma","volume":"26","author":"Cybulska","year":"2018","journal-title":"Gynecol Oncol Rep"},{"key":"10.1016\/j.ygyno.2019.10.028_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ygyno.2016.04.013","article-title":"Primary brain metastases of endometrial cancer: a report of 18 cases and review of the literature","volume":"142","author":"Uccella","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ygyno.2018.10.012","article-title":"Discordant loss of mismatch repair proteins in advanced endometrial endometrioid carcinoma compared to paired primary uterine tumors","volume":"151","author":"Ta","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib30","series-title":"Uterine Neoplasm","author":"National Comprehensive Cancer Network","year":"2019"},{"key":"10.1016\/j.ygyno.2019.10.028_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ygyno.2019.03.247","article-title":"Diagnosis and management of a recurrent polymerase-epsilon (POLE)-mutated endometrial cancer","volume":"153","author":"Veneris","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ygyno.2017.09.015","article-title":"Primum non nocere: are we ready for POLE testing in endometrial cancer?","volume":"147","author":"Cosgrove","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib33","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/s41436-019-0489-y","article-title":"The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome","volume":"21","author":"Crosbie","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.ygyno.2019.10.028_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ctrv.2016.06.008","article-title":"Tumor genotype and immune microenvironment in POLE-ultramutated and MSI-hypermutated Endometrial Cancers: new candidates for checkpoint blockade immunotherapy?","volume":"48","author":"Gargiulo","year":"2016","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.ygyno.2019.10.028_bib35","author":"U.S. Food and Drug Administration"},{"key":"10.1016\/j.ygyno.2019.10.028_bib36","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1172\/JCI84940","article-title":"Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer","volume":"126","author":"Mehnert","year":"2016","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.ygyno.2019.10.028_bib37","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1158\/1078-0432.CCR-16-1031","article-title":"Regression of chemotherapy-resistant polymerase epsilon (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab","volume":"22","author":"Santin","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2019.10.028_bib38","first-page":"JCO1901021","article-title":"Phase II study of avelumab in patients with mismatch repair deficient and mismatch repair proficient recurrent\/persistent endometrial cancer","author":"Konstantinopoulos","year":"2019","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ygyno.2019.10.028_bib39","author":"ClinicalTrialsgov"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825819316154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825819316154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:46:05Z","timestamp":1758771965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825819316154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0090825819316154"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2019.10.028","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2019.10.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}