{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:06:01Z","timestamp":1791889561413,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ygyno.2020.01.019","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T08:28:02Z","timestamp":1579595282000},"page":"245-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D"],"prefix":"10.1016","volume":"157","author":[{"given":"S.","family":"Timmerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Van Rompuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Van Gorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Vanden Bempt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Brems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Van Nieuwenhuysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Neven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Victoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Laenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Vergote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2020.01.019_bb0005","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur. J. Cancer"},{"issue":"10125","key":"10.1016\/j.ygyno.2020.01.019_bb0010","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37,513,025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2020.01.019_bb0015","series-title":"WHO Classification of Tumours of Female Reproductive Organs","author":"Kurman","year":"2014"},{"issue":"4","key":"10.1016\/j.ygyno.2020.01.019_bb0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/IGC.0b013e31821454f1","article-title":"Prognosis and reproducibility of new and existing binary grading systems for endometrial carcinoma compared to FIGO grading in hysterectomy specimens","volume":"21","author":"Guan","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"12","key":"10.1016\/j.ygyno.2020.01.019_bb0025","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/modpathol.2013.102","article-title":"Reproducibility of histological cell type in high-grade endometrial carcinoma","volume":"26","author":"Han","year":"2013","journal-title":"Mod. Pathol."},{"issue":"6","key":"10.1016\/j.ygyno.2020.01.019_bb0030","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/PAS.0b013e31827f576a","article-title":"Poor interobserver reproducibility in the diagnosis of high-grade endometrial carcinoma","volume":"37","author":"Gilks","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.ygyno.2020.01.019_bb0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ygyno.2016.12.015","article-title":"Molecular approaches for classifying endometrial carcinoma","volume":"145","author":"Piulats","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.01.019_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Levine","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ygyno.2020.01.019_bb0045","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00428-017-2279-8","article-title":"The evolution of endometrial carcinoma classification through application of immunohistochemistry and molecular diagnostics: past, present and future","volume":"472","author":"Goebel","year":"2018","journal-title":"Virchows Arch."},{"issue":"2","key":"10.1016\/j.ygyno.2020.01.019_bb0050","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjc.2015.190","article-title":"A clinically applicable molecular-based classification for endometrial cancers","volume":"113","author":"Talhouk","year":"2015","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.ygyno.2020.01.019_bb0055","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/cncr.30496","article-title":"Confirmation of ProMisE: a simple, genomics-based clinical classifier for endometrial cancer","volume":"123","author":"Talhouk","year":"2017","journal-title":"Cancer"},{"issue":"16","key":"10.1016\/j.ygyno.2020.01.019_bb0060","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1158\/1078-0432.CCR-15-2878","article-title":"Improved risk assessment by integrating molecular and clinicopathological factors in early-stage endometrial cancer-combined analysis of the PORTEC cohorts","volume":"22","author":"Stelloo","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.ygyno.2020.01.019_bb0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ygyno.2015.01.541","article-title":"Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas","volume":"137","author":"McConechy","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2020.01.019_bb0070","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2016.07.090","article-title":"Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide treatment","volume":"143","author":"Talhouk","year":"2016","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2020.01.019_bb0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/GCO.0000000000000342","article-title":"Molecular characterization of endometrial cancer and therapeutic implications","volume":"29","author":"Uppendahl","year":"2017","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.ygyno.2020.01.019_bb0080","first-page":"801","article-title":"Genetic susceptibility to non-polyposis colorectal cancer","volume":"36","author":"Lynch","year":"1999","journal-title":"J. Med. Genet."},{"issue":"10","key":"10.1016\/j.ygyno.2020.01.019_bb0085","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra012242","article-title":"Hereditary colorectal cancer","volume":"348","author":"Lynch","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"7447","key":"10.1016\/j.ygyno.2020.01.019_bb0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Kandoth","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ygyno.2020.01.019_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100041","article-title":"Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro","volume":"9","author":"Koppensteiner","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ygyno.2020.01.019_bb0100","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ygyno.2014.01.015","article-title":"Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study","volume":"132","author":"Fleming","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"14","key":"10.1016\/j.ygyno.2020.01.019_bb0105","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1093\/hmg\/ddt131","article-title":"DNA polymerase \u03b5 and \u03b4 exonuclease domain mutations in endometrial cancer","volume":"22","author":"Church","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.ygyno.2020.01.019_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2014.05.006","article-title":"POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium","volume":"134","author":"Meng","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"5","key":"10.1016\/j.ygyno.2020.01.019_bb0115","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/annonc\/mdy058","article-title":"Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series","volume":"29","author":"Kommoss","year":"2018","journal-title":"Ann. Oncol."},{"issue":"8","key":"10.1016\/j.ygyno.2020.01.019_bb0120","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/S1470-2045(12)70213-9","article-title":"Markers for individualised therapy in endometrial carcinoma","volume":"13","author":"Salvesen","year":"2012","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ygyno.2020.01.019_bb0125","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ygyno.2019.03.100","article-title":"Molecular markers in recurrent stage I, grade 1 endometrioid endometrial cancers","volume":"153","author":"Moroney","year":"2019","journal-title":"Gynecol. Oncol."},{"issue":"4","key":"10.1016\/j.ygyno.2020.01.019_bb0130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41416-018-0187-6","article-title":"L1CAM further stratifies endometrial carcinoma patients with no specific molecular risk profile","volume":"119","author":"Kommoss","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"Suppl. 6","key":"10.1016\/j.ygyno.2020.01.019_bb0135","doi-asserted-by":"crossref","first-page":"vi33","DOI":"10.1093\/annonc\/mdt353","article-title":"Endometrial cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Colombo","year":"2013","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2020.01.019_bb0140","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/cncr.29046","article-title":"Polymerase \u025b (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing","volume":"121","author":"Billingsley","year":"2015","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.ygyno.2020.01.019_bb0145","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1101\/gr.174789.114","article-title":"Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication","volume":"24","author":"Shinbrot","year":"2014","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.ygyno.2020.01.019_bb0150","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/modpathol.2014.143","article-title":"Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations","volume":"28","author":"Hussein","year":"2015","journal-title":"Mod. Pathol."},{"issue":"3","key":"10.1016\/j.ygyno.2020.01.019_bb0155","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ygyno.2019.03.098","article-title":"Molecular classification defines outcomes and opportunities in young women with endometrial carcinoma","volume":"153","author":"Britton","year":"2019","journal-title":"Gynecol. Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820300615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820300615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:51:50Z","timestamp":1758772310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825820300615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0090825820300615"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.01.019","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}