{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:58:19Z","timestamp":1794265099000,"version":"4.9.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ygyno.2020.08.025","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T08:39:14Z","timestamp":1599122354000},"page":"636-641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study"],"prefix":"10.1016","volume":"159","author":[{"given":"Giorgio","family":"BOGANI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violante","family":"DI DONATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"SOPRACORDEVOLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"CIAVATTINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"GHELARDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"LOPEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"SIMONCINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"PLOTTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jvan","family":"CASARIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"SERATI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"PINELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"VALENTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"BERGAMINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"GARDELLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"DELL'ACQUA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermelinda","family":"MONTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"VERCELLINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"FISCHETTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"D'IPPOLITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"AGUZZOLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo D.","family":"MANDATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"CARUNCHIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"CARLINFANTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"GIANNELLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cono","family":"SCAFFA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"FALCONE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"BORGHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"DITTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"MALZONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"GIANNINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"SALERNO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"LIBERALE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"CONTINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"DONFRANCESCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"DESIATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Myriam","family":"PERRONE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"DONDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierandrea","family":"De IACO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"LEONE ROBERTI MAGGIORE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"SIGNORELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"CHIAPPA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"FERRERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"SARPIETRO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"MATARAZZO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"CIANCI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"BOSIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"RUISI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"GUERRISI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"BRUSADELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"MOSCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"TINELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"DE VINCENZO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Franco","family":"ZANNONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"FERRANDINA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"PETRILLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"DESSOLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"ANGIOLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"GREGGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsenio","family":"SPINILLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"GHEZZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"COLACURCI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"MUZII","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"BENEDETTI PANICI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"SCAMBIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"RASPAGLIESI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2020.08.025_bb0005","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0010","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ijc.32752","article-title":"Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status","volume":"147","author":"Sand","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0015","doi-asserted-by":"crossref","unstructured":"Sahlgren H, Elfstr\u00f6m KM, Lamin H, et al. Colposcopic and histopathologic evaluation of women with HPV persistence exiting an organized screening program. Am J Obstet Gynecol 2020;222:253.e1\u2013253.e8. doi:https:\/\/doi.org\/10.1016\/j.ajog.2019.09.039","DOI":"10.1016\/j.ajog.2019.09.039"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/CEJ.0000000000000475","article-title":"Nomogram-based prediction of cervical dysplasia persistence\/recurrence","volume":"28","author":"Bogani","year":"2019","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0025","doi-asserted-by":"crossref","unstructured":"Athanasiou A, Veroniki AA, Efthimiou O, et al. Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group. BMJ Open 2019;9:e028008. Published 2019 Aug 2. Doi:https:\/\/doi.org\/10.1136\/bmjopen-2018-028008","DOI":"10.1136\/bmjopen-2018-028008"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0030","first-page":"4345","article-title":"Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer","volume":"34","author":"Sopracordevole","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/LGT.0000000000000439","article-title":"Comparison of electrosurgical devices for cervical Conization: novel Monopolar scalpel (VIO) versus ultrasonic scalpel","volume":"23","author":"Akazawa","year":"2019","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0040","first-page":"803","article-title":"Complications of laser conization versus loop electrosurgical excision procedure in pre- and postmenopausal patients","volume":"37","author":"Kiuchi","year":"2016","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0301-2115(02)00245-2","article-title":"Long-term outcome of a randomized study comparing three techniques of conization: cold knife, laser, and LEEP","volume":"106","author":"Mathevet","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/gyno.1996.0088","article-title":"One-session Management of Cervical Intraepithelial Neoplasia: a solution for developing countries. A prospective, randomized trial of LEEP versus laser excisional Conization","volume":"61","author":"Santos","year":"1996","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0055","unstructured":"IARC working group. Monographs. Human papillomaviruses. Available at: https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono100B-11.pdf Last accessed 07\/07\/2020."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejogrb.2019.07.014","article-title":"Adenocarcinoma in situ of the uterine cervix: clinical practice guidelines from the Italian society of colposcopy and cervical pathology (SICPCV)","volume":"240","author":"Ciavattini","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ygyno.2019.04.007","article-title":"Long-term results of fertility-sparing treatment for early-stage cervical cancer","volume":"154","author":"Bogani","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0070","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ygyno.2016.02.016","article-title":"Incorporating robotic-assisted surgery for endometrial cancer staging: analysis of morbidity and costs","volume":"141","author":"Bogani","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0075","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1001\/jama.291.17.2100","article-title":"Treatment for cervical intraepithelial neoplasia and risk of preterm delivery","volume":"291","author":"Sadler","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0080","doi-asserted-by":"crossref","unstructured":"Kyrgiou M, Athanasiou A, Paraskevaidi M, et al. Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis. BMJ 2016;354:i3633. Published 2016 Jul 28. Doi:https:\/\/doi.org\/10.1136\/bmj.i3633","DOI":"10.1136\/bmj.i3633"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0085","doi-asserted-by":"crossref","unstructured":"Hurtado-Roca Y, Becerra-Chauca N, Malca M. Efficacy and safety of cryotherapy, cold cone or thermocoagulation compared to LEEP as a therapy for cervical intraepithelial neoplasia: Systematic review. Rev Saude Publica. 2020;54:27. Published 2020 Mar 16. Doi:10.11606\/s1518-8787.2020054001750","DOI":"10.11606\/s1518-8787.2020054001750"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0090","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(15)00239-1","article-title":"Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2\/3: a randomized, double-blind, placebo-controlled phase 2b trial","volume":"386","author":"Trimble","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0095","unstructured":"WHO. WHO guidelines for treatment of cervical intraepithelial neoplasia 2\u20133 and adenocarcinoma in situ. Available at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/104174\/9789241506779_eng.pdf?sequence=1. Last accessed: July 16, 2020."},{"key":"10.1016\/j.ygyno.2020.08.025_bb0100","doi-asserted-by":"crossref","unstructured":"Mitra A, MacIntyre DA, Ntritsos G, et al. The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nat Commun. 2020;11(1):1999. Published 2020 Apr 24. doi:https:\/\/doi.org\/10.1038\/s41467-020-15856-y","DOI":"10.1038\/s41467-020-15856-y"},{"key":"10.1016\/j.ygyno.2020.08.025_bb0105","doi-asserted-by":"crossref","unstructured":"Rossi PG, Carozzi F, Ronco G, et al. p16\/ki67 and E6\/E7 mRNA accuracy and prognostic value in triaging HPV DNA-positive women [published online ahead of print, 2020 Aug 3]. J Natl Cancer Inst. 2020;djaa105. doi:https:\/\/doi.org\/10.1093\/jnci\/djaa105","DOI":"10.1093\/jnci\/djaa105"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820338269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820338269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:56:08Z","timestamp":1758772568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825820338269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0090825820338269"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.08.025","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}