{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:45:45Z","timestamp":1794037545153,"version":"4.8.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ygyno.2020.11.026","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T01:53:20Z","timestamp":1607824400000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Stromal POSTN induced by TGF-\u03b21 facilitates the migration and invasion of ovarian cancer"],"prefix":"10.1016","volume":"160","author":[{"given":"Huiran","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2020.11.026_bb0005","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0010","first-page":"280","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1172\/JCI93554","article-title":"The fibrotic tumor stroma","volume":"128","author":"Yamauchi","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0020","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ygyno.2018.11.014","article-title":"Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer","volume":"152","author":"Zhang","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12943-017-0732-6","article-title":"Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression","volume":"16","author":"Yang","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10110406","article-title":"Cancer Associated Fibroblasts: Naughty Neighbors that Drive Ovarian Cancer Progression","volume":"10","author":"Dasari","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0035","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41388-018-0637-x","article-title":"An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment","volume":"38","author":"Motohara","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0040","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1186\/s12885-019-6470-y","article-title":"Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer","volume":"19","author":"Yue","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0045","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s13402-020-00513-9","article-title":"Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles","volume":"43","author":"Yousefi","year":"2020","journal-title":"Cellular Oncol. (Dordrecht)"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0050","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00018-013-1494-y","article-title":"The role of periostin in tissue remodeling across health and disease","volume":"71","author":"Conway","year":"2014","journal-title":"Cellular Mol. Life Sci."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0055","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1128\/MCB.24.9.3992-4003.2004","article-title":"Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression","volume":"24","author":"Shao","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1535-6108(04)00081-9","article-title":"Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt\/PKB pathway","volume":"5","author":"Bao","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0065","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3892\/ijo.2013.1847","article-title":"Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype","volume":"42","author":"Wang","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fonc.2018.00225","article-title":"Periostin: a Matricellular protein with multiple functions in cancer development and progression","volume":"8","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0075","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ygyno.2010.07.008","article-title":"Periostin promotes ovarian cancer angiogenesis and metastasis","volume":"119","author":"Zhu","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0080","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1158\/1078-0432.CCR-14-3111","article-title":"Upregulation of Periostin and reactive Stroma is associated with primary Chemoresistance and predicts clinical outcomes in epithelial ovarian Cancer","volume":"21","author":"Ryner","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0085","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.18632\/oncotarget.6700","article-title":"Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma","volume":"7","author":"Sung","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0090","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/cas.13567","article-title":"Cross-talk between ovarian cancer cells and macrophages through periostin promotes macrophage recruitment","volume":"109","author":"Tang","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0095","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ygyno.2013.12.021","article-title":"POSTN\/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer","volume":"132","author":"Karlan","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0100","first-page":"301","article-title":"A FXYD5\/TGF-\u03b2\/SMAD positive feedback loop drives epithelial-to-mesenchymal transition and promotes tumor growth and metastasis in ovarian cancer","volume":"56","author":"Bai","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0105","doi-asserted-by":"crossref","first-page":"bat013","DOI":"10.1093\/database\/bat013","article-title":"OvarianData: clinically annotated data for the ovarian cancer transcriptome","volume":"2013","author":"Ganzfried","year":"2013","journal-title":"Database"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0110","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","article-title":"Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome","volume":"14","author":"Tothill","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature10694","article-title":"Interactions between cancer stem cells and their niche govern metastatic colonization","volume":"481","author":"Malanchi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0125","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.celrep.2018.02.035","article-title":"Periostin limits tumor response to VEGFA inhibition","volume":"22","author":"Keklikoglou","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0130","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","article-title":"Integrin signaling in Cancer: Mechanotransduction, Stemness, epithelial plasticity, and therapeutic resistance","volume":"35","author":"Cooper","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/embor.2009.276","article-title":"Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing","volume":"11","author":"Margadant","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12935-020-01344-2","article-title":"The prognostic value of ITGA and ITGB superfamily members in patients with high grade serous ovarian cancer","volume":"20","author":"Zhu","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0150","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1158\/0008-5472.CAN-07-5167","article-title":"Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target","volume":"68","author":"Sawada","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2020.11.026_bb0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1593\/neo.101720","article-title":"Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer","volume":"13","author":"Schauer","year":"2011","journal-title":"Neoplasia (New York, N.Y.)"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/carcin\/bgr230","article-title":"Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness","volume":"33","author":"Cai","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ygyno.2020.11.026_bb0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/path.4889","article-title":"Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer","volume":"242","author":"Rynne-Vidal","year":"2017","journal-title":"J. Pathol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820341548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825820341548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:53:32Z","timestamp":1758772412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825820341548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0090825820341548"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.11.026","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stromal POSTN induced by TGF-\u03b21 facilitates the migration and invasion of ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2020.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}