{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:47:54Z","timestamp":1791082074680,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201904010490"],"award-info":[{"award-number":["201904010490"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","gynecologiconcology-online.net","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ygyno.2021.02.024","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T03:57:44Z","timestamp":1614743864000},"page":"613-620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Enrichment and detection method for the prognostic value of circulating tumor cells in ovarian cancer: A meta-analysis"],"prefix":"10.1016","volume":"161","author":[{"given":"Chengying","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2021.02.024_bb0005","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0010","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1186\/s12885-018-4498-z","article-title":"Changes in ovarian cancer survival during the 20 years before the era of targeted therapy","volume":"18","author":"Lee","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13048-019-0503-7","article-title":"Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review","volume":"12","author":"Dochez","year":"2019","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0020","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41571-019-0187-3","article-title":"Liquid biopsy and minimal residual disease - latest advances and implications for cure","volume":"16","author":"Pantel","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061632","article-title":"EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis","volume":"12","author":"Genna","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0030","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1039\/C6CS00803H","article-title":"Current detection technologies for circulating tumor cells","volume":"46","author":"Shen","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0035","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1158\/1078-0432.CCR-17-2092","article-title":"Cell-free DNA and circulating tumor cells: comprehensive liquid biopsy analysis in advanced breast Cancer","volume":"24","author":"Rossi","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s13402-018-0386-4","article-title":"Mesenchymal marker and LGR5 expression levels in circulating tumor cells correlate with colorectal cancer prognosis","volume":"41","author":"Wang","year":"2018","journal-title":"Cell Oncol (Dordr)."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0045","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3389\/fonc.2020.00582","article-title":"New screening test improves detection of prostate cancer using circulating tumor cells and prostate-specific markers","volume":"10","author":"Ried","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0050","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00404-020-05477-7","article-title":"Clinical relevance of circulating tumor cells in ovarian, fallopian tube and peritoneal cancer","volume":"301","author":"Banys-Paluchowski","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0055","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/IGC.0b013e3182907109","article-title":"Pooled Analysis of the Prognostic Relevance of Disseminated Tumor Cells in the Bone Marrow of Patients With Ovarian Cancer","volume":"23","author":"Fehm","year":"2013","journal-title":"Int. J. Gynecol.Cancer"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0060","doi-asserted-by":"crossref","first-page":"48820","DOI":"10.18632\/oncotarget.16179","article-title":"EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy","volume":"8","author":"Chebouti","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ygyno.2003.08.004","article-title":"Preoperative detection of peripherally circulating cancer cells and its prognostic significance in ovarian cancer","volume":"91","author":"Judson","year":"2003","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0070","first-page":"707","article-title":"Circulating tumor cells in the peripheral blood and bone marrow of patients with ovarian carcinoma do not predict prognosis","volume":"94","author":"Marth","year":"2002","journal-title":"Cancer Am. Cancer Soc."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ygyno.2008.09.021","article-title":"Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer","volume":"112","author":"Fan","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0080","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/IGC.0b013e318216cb91","article-title":"Molecular profiling and prognostic relevance of circulating tumor cells in the blood of ovarian cancer patients at primary diagnosis and after platinum-based chemotherapy","volume":"21","author":"Aktas","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ygyno.2011.06.022","article-title":"Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a gynecologic oncology group study","volume":"123","author":"Behbakht","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ygyno.2011.05.028","article-title":"Circulating tumor cells predict progression free survival and overall survival in patients with relapsed\/recurrent advanced ovarian cancer","volume":"122","author":"Poveda","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygyno.2013.08.006","article-title":"Predictive value of circulating tumor cells (CTCs) in newly-diagnosed and recurrent ovarian cancer patients","volume":"131","author":"Liu","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2012.09.021","article-title":"Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium","volume":"128","author":"Obermayr","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0105","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1373\/clinchem.2014.224808","article-title":"ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance","volume":"60","author":"Kuhlmann","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ygyno.2014.06.013","article-title":"Prognostic analysis of invasive circulating tumor cells (iCTCs) in epithelial ovarian cancer","volume":"134","author":"Pearl","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/1354750X.2013.865275","article-title":"Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer","volume":"19","author":"Sang","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ygyno.2017.02.042","article-title":"Predictive value of circulating tumor cells (CTCs) captured by microfluidic device in patients with epithelial ovarian cancer","volume":"145","author":"Lee","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1745-6215-8-16","article-title":"Practical methods for incorporating summary time-to-event data into meta-analysis","volume":"8","author":"Tierney","year":"2007","journal-title":"Trials"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0130","doi-asserted-by":"crossref","first-page":"e15354","DOI":"10.1097\/MD.0000000000015354","article-title":"Post-debulking circulating tumor cell as a poor prognostic marker in advanced stage ovarian cancer: A prospective observational study","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0135","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0140-6736(95)92054-4","article-title":"Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy","volume":"346","author":"Eschw\u00e8ge","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1477-7819-4-67","article-title":"Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells","volume":"4","author":"Camara","year":"2006","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF01268852","article-title":"Detection of circulating prostatic cells during radical prostatectomy","volume":"25","author":"Planz","year":"1997","journal-title":"Urol. Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0150","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1159\/000492521","article-title":"Analysis of circulating tumor cells in ovarian Cancer and their clinical value as a biomarker","volume":"48","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-981-13-0502-3_5","article-title":"Circulating tumor cells: the importance of single cell analysis","volume":"1068","author":"Heymann","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00408-015-9697-7","article-title":"Circulating tumor cells in lung cancer: detection methods and clinical applications","volume":"193","author":"Yu","year":"2015","journal-title":"Lung."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13045-019-0735-4","article-title":"Technologies for circulating tumor cell separation from whole blood","volume":"12","author":"Bank\u00f3","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4939-2990-0_18","article-title":"Detection and characterization of circulating tumor cells by the cellsearch approach","volume":"1347","author":"Coumans","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0175","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1158\/1078-0432.CCR-06-1695","article-title":"Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system","volume":"13","author":"Riethdorf","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0180","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1200\/JCO.2005.08.140","article-title":"Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer","volume":"23","author":"Cristofanilli","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0185","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.humpath.2003.08.026","article-title":"Frequent EpCam protein expression in human carcinomas","volume":"35","author":"Went","year":"2004","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.acc.2017.10.004","article-title":"Circulating tumor cells and implications of the epithelial-to-Mesenchymal transition","volume":"83","author":"Lowes","year":"2018","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0195","doi-asserted-by":"crossref","first-page":"8319","DOI":"10.1158\/0008-5472.CAN-06-0410","article-title":"Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis","volume":"66","author":"Christiansen","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0200","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/annonc\/mdu018","article-title":"Circulating tumour cells: the evolving concept and the inadequacy of their enrichment by EpCAM-based methodology for basic and clinical cancer research","volume":"25","author":"Grover","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0205","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.2147\/CMAR.S211455","article-title":"Circulating tumor cell detection in epithelial ovarian Cancer using dual-component antibodies targeting EpCAM and FR\u03b1","volume":"11","author":"Li","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.ygyno.2021.02.024_bb0210","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/1471-2407-12-178","article-title":"Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition","volume":"12","author":"Gorges","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ygyno.2021.02.024_bb0215","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201010021","article-title":"Circulating tumor cells: approaches to isolation and characterization","volume":"192","author":"Yu","year":"2011","journal-title":"J. Cell Biol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825821001694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825821001694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:47:38Z","timestamp":1715820458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825821001694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0090825821001694"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2021.02.024","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enrichment and detection method for the prognostic value of circulating tumor cells in ovarian cancer: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2021.02.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}