{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:20:07Z","timestamp":1793989207740,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["15\/RIG\/1-16"],"award-info":[{"award-number":["15\/RIG\/1-16"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008667","name":"National Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C22375\/A12846"],"award-info":[{"award-number":["C22375\/A12846"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C22375\/A13784"],"award-info":[{"award-number":["C22375\/A13784"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["1063014"],"award-info":[{"award-number":["1063014"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["2009-2011"],"award-info":[{"award-number":["2009-2011"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["632740"],"award-info":[{"award-number":["632740"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["APP1142697"],"award-info":[{"award-number":["APP1142697"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ygyno.2021.07.024","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:34:35Z","timestamp":1629142475000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["A phase 2 study of anastrozole in patients with oestrogen receptor and\/progesterone receptor positive recurrent\/metastatic granulosa cell tumours\/sex-cord stromal tumours of the ovary: The PARAGON\/ANZGOG 0903 trial"],"prefix":"10.1016","volume":"163","author":[{"given":"Susana N.","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sjoquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Clamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Nottley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Menon","family":"Mullassery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Gourley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Bonaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"McNally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Carty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Divers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Edmondson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedlander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygyno.2021.07.024_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13193-012-0201-z","article-title":"Recent advances in granulosa cell tumor ovary: a review","volume":"4","author":"Kottarathil","year":"2013","journal-title":"Indian J. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ygyno.2011.03.020","article-title":"Patterns of spread and recurrence of sex cord-stromal tumors of the ovary","volume":"122","author":"Thrall","year":"2011","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ygyno.2013.12.012","article-title":"The role of FOXL2 in the pathogenesis of adult ovarian granulosa cell tumours","volume":"133","author":"Rosario","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"26","key":"10.1016\/j.ygyno.2021.07.024_bb0020","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1056\/NEJMoa0902542","article-title":"Mutation of FOXL2 in granulosa-cell tumors of the ovary","volume":"360","author":"Shah","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygyno.2021.07.024_bb0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biocel.2016.01.003","article-title":"Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors","volume":"72","author":"Leung","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.ygyno.2021.07.024_bb0030","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/IGC.0b013e3181a702d1","article-title":"The role of inhibins B and antimullerian hormone for diagnosis and follow-up of granulosa cell tumors","volume":"19","author":"Geerts","year":"2009","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ygyno.2006.12.034","article-title":"Granulosa cell tumors of the ovary: the clinical value of serum inhibin a and B levels in a large single center cohort","volume":"105","author":"Mom","year":"2007","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2021.07.024_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2007.08.007","article-title":"Granulosa cell tumor of the ovary","volume":"34","author":"Pectasides","year":"2008","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.ygyno.2021.07.024_bb0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/bjc.2013.241","article-title":"Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary","volume":"109","author":"Mangili","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.ygyno.2021.07.024_bb0050","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/gyno.1996.0078","article-title":"Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature","volume":"60","author":"Hines","year":"1996","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.07.024_bb0055","article-title":"Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent)","volume":"4","author":"Gurumurthy","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.ygyno.2021.07.024_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ygyno.2014.12.026","article-title":"The role of systemic chemotherapy in the management of granulosa cell tumors","volume":"136","author":"Meisel","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"4","key":"10.1016\/j.ygyno.2021.07.024_bb0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/pgp.0b013e31805c0d99","article-title":"Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors","volume":"26","author":"Farinola","year":"2007","journal-title":"Int. J. Gynecol. Pathol."},{"issue":"7","key":"10.1016\/j.ygyno.2021.07.024_bb0070","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/PAT.0b013e328359d636","article-title":"Immunohistochemical expression and prognostic significance of oestrogen receptor-alpha, oestrogen receptor-beta, and progesterone receptor in stage 1 adult-type granulosa cell tumour of the ovary","volume":"44","author":"Hutton","year":"2012","journal-title":"Pathology"},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0075","doi-asserted-by":"crossref","first-page":"IJE08","DOI":"10.2217\/ije-2017-0021","article-title":"Ovarian adult-type granulosa cell tumor: focusing on endocrine-based therapies","volume":"5","author":"Yang","year":"2018","journal-title":"Int. J. Endocr. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2021.07.024_bb0080","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ygyno.2014.03.573","article-title":"Hormone therapy in ovarian granulosa cell tumors: a systematic review","volume":"134","author":"van Meurs","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2021.07.024_bb0085","doi-asserted-by":"crossref","first-page":"iv305","DOI":"10.1093\/annonc\/mdu338.3","article-title":"877PD\u2014Clinical outcomes of recurrent ovarian granulosa cell tumours treated with letrozole: A 10-year retrospective case-series of the Royal Marsden Hospital","volume":"25","author":"Canario","year":"2014","journal-title":"Ann. Oncol."},{"issue":"11","key":"10.1016\/j.ygyno.2021.07.024_bb0090","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/aogs.12720","article-title":"Evaluation of response to hormone therapy in patients with measurable adult granulosa cell tumors of the ovary","volume":"94","author":"van Meurs","year":"2015","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"7","key":"10.1016\/j.ygyno.2021.07.024_bb0095","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1097\/IGC.0b013e31821d6021","article-title":"The role of hormonal therapy in gynecological cancers-current status and future directions","volume":"21","author":"Sjoquist","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"6","key":"10.1016\/j.ygyno.2021.07.024_bb0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s11912-013-0343-3","article-title":"Hormonal treatment in recurrent and metastatic gynaecological cancers: a review of the current literature","volume":"15","author":"Sommeijer","year":"2013","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.ygyno.2021.07.024_bb0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/01621459.1927.10502953","article-title":"Probable inference, the law of succession, and statistical inference","volume":"22","author":"Wilson","year":"1927","journal-title":"J. Am. Stat. Assoc."},{"issue":"Suppl. 2","key":"10.1016\/j.ygyno.2021.07.024_bb0110","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1111\/j.1524-4733.2007.00278.x","article-title":"National Cancer Institute of Canada Clinical Trials Group. Evaluating health-related quality of life in cancer clinical trials: the National Cancer Institute of Canada Clinical Trials Group experience","volume":"10","author":"Osoba","year":"2007","journal-title":"Value Health"},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12350-019-01624-z","article-title":"Landmark analysis: a primer","volume":"26","author":"Morgan","year":"2019","journal-title":"J. Nucl. Cardiol."},{"issue":"4","key":"10.1016\/j.ygyno.2021.07.024_bb0120","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaa034","article-title":"Functional profiling of FSH and estradiol in ovarian granulosa cell tumors","volume":"4","author":"Haltia","year":"2020","journal-title":"J Endocr. Soc."},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00006250-198602000-00020","article-title":"Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary","volume":"67","author":"Colombo","year":"1986","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.ygyno.2021.07.024_bb0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0029-7844(95)00491-2","article-title":"Treatment of poor-prognosis sex cord-stromal tumors of the ovary with the combination of bleomycin, etoposide, and cisplatin","volume":"87","author":"Gershenson","year":"1996","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/gyno.1998.5304","article-title":"Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: a gynecologic oncology group study","volume":"72","author":"Homesley","year":"1999","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2021.07.024_bb0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ygyno.2005.01.011","article-title":"The activity of taxanes compared with bleomycin, etoposide, and cisplatin in the treatment of sex cord-stromal ovarian tumors","volume":"97","author":"Brown","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2021.07.024_bb0145","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/cncr.28421","article-title":"Efficacy and safety of bevacizumab in recurrent sex cord-stromal ovarian tumors: results of a phase 2 trial of the gynecologic oncology group","volume":"120","author":"Brown","year":"2014","journal-title":"Cancer."},{"issue":"12","key":"10.1016\/j.ygyno.2021.07.024_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamaoncol.2020.4574","article-title":"Effect of weekly paclitaxel with or without bevacizumab on progression-free rate among patients with relapsed ovarian sex cord-stromal tumors: the ALIENOR\/ENGOT-ov7 randomized clinical trial","volume":"6","author":"Ray-Coquard","year":"2020","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2021.07.024_bb0155","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ygyno.2018.05.013","article-title":"Estrogen receptor \u03b2: potential target for therapy in adult granulosa cell tumors?","volume":"150","author":"Ciucci","year":"2018","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2021.07.024_bb0160","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/cancers12061398","article-title":"Molecular pathways and targeted therapies for malignant ovarian germ cell tumors and sex cord-stromal tumors: a contemporary review","volume":"12","author":"Maoz","year":"2020","journal-title":"Cancers (Basel)."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825821005862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825821005862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:59:45Z","timestamp":1758772785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825821005862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0090825821005862"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2021.07.024","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A phase 2 study of anastrozole in patients with oestrogen receptor and\/progesterone receptor positive recurrent\/metastatic granulosa cell tumours\/sex-cord stromal tumours of the ovary: The PARAGON\/ANZGOG 0903 trial","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2021.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}