{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:03:12Z","timestamp":1784818992499,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","award":["570806"],"award-info":[{"award-number":["570806"]}],"id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012684","name":"Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2 TR003168"],"award-info":[{"award-number":["KL2 TR003168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR003167"],"award-info":[{"award-number":["UL1 TR003167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ygyno.2022.09.026","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T22:18:30Z","timestamp":1665440310000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gynecologic tract melanoma in the contemporary therapeutic era: High rates of local and distant disease progression"],"prefix":"10.1016","volume":"167","author":[{"given":"Devarati","family":"Mitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Farr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadharsini","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Jhingran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan S.","family":"Farooqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frumovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodabe N.","family":"Amaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"McQuade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Jazaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Ashleigh","family":"Guadagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ygyno.2022.09.026_bb0005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ygyno.2004.09.052","article-title":"Population-based incidence rates of malignant melanoma of the vulva in Germany","volume":"96","author":"Stang","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2022.09.026_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ctrv.2018.12.005","article-title":"Vulvar malignant melanoma: pathogenesis, clinical behaviour and management: Review of the literature","volume":"73","author":"Boer","year":"2019","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"10.1016\/j.ygyno.2022.09.026_bb0015","first-page":"4017","article-title":"Primary malignant melanomas of the female lower genital tract: clinicopathological characteristics and management","volume":"10","author":"Wang","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"10","key":"10.1016\/j.ygyno.2022.09.026_bb0020","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1002\/1097-0142(19940515)73:10<2626::AID-CNCR2820731026>3.0.CO;2-U","article-title":"Malignant melanoma of the vulva treated by radical hemivulvectomy. A prospective study of the Gynecologic Oncology Group","volume":"73","author":"Phillips","year":"1994","journal-title":"Cancer."},{"issue":"3","key":"10.1016\/j.ygyno.2022.09.026_bb0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0090-8258(92)90300-8","article-title":"Management of vulvar melanoma","volume":"45","author":"Trimble","year":"1992","journal-title":"Gynecol. Oncol."},{"issue":"5","key":"10.1016\/j.ygyno.2022.09.026_bb0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1136\/ijgc-00009577-200109000-00004","article-title":"Vulvar melanoma at the M. D. Anderson Cancer Center: 25 years later","volume":"11","author":"Verschraegen","year":"2001","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"2 Pt 1","key":"10.1016\/j.ygyno.2022.09.026_bb0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.AOG.0000271209.67461.91","article-title":"Vulvar melanoma: a multivariable analysis of 644 patients","volume":"110","author":"Sugiyama","year":"2007","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.ygyno.2022.09.026_bb0040","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/AOG.0b013e3181fb8045","article-title":"Primary malignant melanoma of the vagina","volume":"116","author":"Frumovitz","year":"2010","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.ygyno.2022.09.026_bb0045","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1245\/s10434-014-4215-3","article-title":"Melanoma of the vulva and vagina: principles of staging and their relevance to management based on a clinicopathologic analysis of 85 cases","volume":"22","author":"Seifried","year":"2015","journal-title":"Ann. Surg. Oncol."},{"issue":"8","key":"10.1016\/j.ygyno.2022.09.026_bb0050","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1158\/1078-0432.CCR-16-2126","article-title":"Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: a retrospective review of 100 cases","volume":"23","author":"Nagarajan","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.ygyno.2022.09.026_bb0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40257-019-00487-x","article-title":"Malignant melanoma of the vulva and vagina: A US population-based study of 1863 patients","volume":"21","author":"Wohlmuth","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.ygyno.2022.09.026_bb0060","doi-asserted-by":"crossref","first-page":"999","DOI":"10.21873\/anticanres.14854","article-title":"Lower genital tract melanomas: staging, predictors of outcome, and new therapeutic options","volume":"41","author":"Egger","year":"2021","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.ygyno.2022.09.026_bb0065","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2020.31.e66","article-title":"Vulvar melanoma: an analysis of prognostic factors and treatment patterns","volume":"31","author":"Albert","year":"2020","journal-title":"J. Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2022.09.026_bb0070","first-page":"190","article-title":"Primary melanoma of the vagina: a clinicopathologic analysis","volume":"74","author":"Reid","year":"1989","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.ygyno.2022.09.026_bb0075","first-page":"295","article-title":"Malignant melanoma of the vagina. A report of 15 cases","volume":"21","author":"Cobellis","year":"2000","journal-title":"Eur. J. Gynaecol. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2022.09.026_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF02524343","article-title":"Primary vaginal melanoma: a critical analysis of therapy","volume":"11","author":"Miner","year":"2004","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2022.09.026_bb0085","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.critrevonc.2011.03.008","article-title":"A literature overview of primary cervical malignant melanoma: an exceedingly rare cancer","volume":"81","author":"Pusceddu","year":"2012","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"8","key":"10.1016\/j.ygyno.2022.09.026_bb0090","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/IGC.0b013e3182a1ced8","article-title":"Treatment approach and outcomes of vaginal melanoma","volume":"23","author":"Kirschner","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"9 Suppl 3","key":"10.1016\/j.ygyno.2022.09.026_bb0095","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1097\/IGC.0000000000000198","article-title":"Gynecologic Cancer InterGroup (GCIG) consensus review for vulvovaginal melanomas","volume":"24","author":"Leitao","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"6","key":"10.1016\/j.ygyno.2022.09.026_bb0100","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41416-018-0207-6","article-title":"Antitumour activity of pembrolizumab in advanced mucosal melanoma: a post-hoc analysis of KEYNOTE-001, 002, 006","volume":"119","author":"Hamid","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"21","key":"10.1016\/j.ygyno.2022.09.026_bb0105","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1002\/cncr.30259","article-title":"The efficacy of anti-PD-1 agents in acral and mucosal melanoma","volume":"122","author":"Shoushtari","year":"2016","journal-title":"Cancer."},{"issue":"7653","key":"10.1016\/j.ygyno.2022.09.026_bb0110","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.ygyno.2022.09.026_bb0115","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1186\/s12885-015-1750-7","article-title":"Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma: a meta-analysis","volume":"15","author":"Li","year":"2015","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.ygyno.2022.09.026_bb0120","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/hed.26470","article-title":"The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: systematic review and meta-analysis","volume":"43","author":"Grant-Freemantle","year":"2021","journal-title":"Head Neck"},{"issue":"22","key":"10.1016\/j.ygyno.2022.09.026_bb0125","article-title":"Outcomes after sphincter-sparing local therapy for anorectal melanoma: 1989 to 2020","volume":"S1879-8500","author":"Mitra","year":"2022","journal-title":"Pract. Radiat. Oncol."},{"issue":"15_suppl","key":"10.1016\/j.ygyno.2022.09.026_bb0130","doi-asserted-by":"crossref","first-page":"9512","DOI":"10.1200\/JCO.2021.39.15_suppl.9512","article-title":"A phase 2 clinical trial of neoadjuvant anti-PD-1 ab (Toripalimab) plus axitinib in resectable mucosal melanoma","volume":"39","author":"Cui","year":"2021","journal-title":"JCO."},{"issue":"7","key":"10.1016\/j.ygyno.2022.09.026_bb0135","doi-asserted-by":"crossref","first-page":"e378","DOI":"10.1016\/S1470-2045(19)30332-8","article-title":"Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium","volume":"20","author":"Amaria","year":"2019","journal-title":"Lancet Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825822018546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825822018546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:29:03Z","timestamp":1778664543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825822018546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0090825822018546"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2022.09.026","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gynecologic tract melanoma in the contemporary therapeutic era: High rates of local and distant disease progression","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2022.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}