{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:28:31Z","timestamp":1780579711851,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ygyno.2023.10.014","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T16:41:26Z","timestamp":1699548086000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Vulvar squamous cell carcinoma in women 80\u00a0years and older: Treatment, survival and impact of comorbidities"],"prefix":"10.1016","volume":"179","author":[{"given":"Melinda S.","family":"Schuurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus","family":"Veldmate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e M.F.","family":"Ebisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne A.","family":"de Hullu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery E.P.P","family":"Lemmens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike A.","family":"van der Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2023.10.014_bb0005","unstructured":"Netherlands Cancer Registry (NCR), Netherlands Comprehensive Cancer Organisation (IKNL), 4 october 2-23, Available from: www.iknl.nl\/en\/ncr\/ncr-data-figures, accessed [04 October 2023]."},{"key":"10.1016\/j.ygyno.2023.10.014_bb0010","unstructured":"Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https:\/\/gco.iarc.fr\/today, accessed [04 October 2023]."},{"issue":"18","key":"10.1016\/j.ygyno.2023.10.014_bb0015","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1016\/j.ejca.2013.08.003","article-title":"Trends in incidence and survival of Dutch women with vulvar squamous cell carcinoma","volume":"49","author":"Schuurman","year":"2013","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0020","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ygyno.2017.03.008","article-title":"Vulvar carcinoma in Norway: a 50-year perspective on trends in incidence, treatment and survival","volume":"145","author":"Meltzer-Gunnes","year":"2017","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2023.10.014_bb0025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00432-016-2135-2","article-title":"Trends in surgery and outcomes of squamous cell vulvar cancer patients over a 16-year period (1998-2013): a population-based analysis","volume":"142","author":"Rottmann","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0030","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2015-000020","article-title":"Challenge of cancer in the elderly","volume":"1","author":"Marosi","year":"2016","journal-title":"ESMO Open."},{"issue":"9","key":"10.1016\/j.ygyno.2023.10.014_bb0035","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/bjc.2011.407","article-title":"Risk factors for short- and long-term complications after groin surgery in vulvar cancer","volume":"105","author":"Hinten","year":"2011","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.ygyno.2023.10.014_bb0040","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/ijgc-00009577-200307000-00019","article-title":"Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions","volume":"13","author":"Gaarenstroom","year":"2003","journal-title":"Int. J. Gynecolog. Cancer"},{"issue":"2","key":"10.1016\/j.ygyno.2023.10.014_bb0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ygyno.2013.07.082","article-title":"A review of complications associated with the surgical treatment of vulvar cancer","volume":"131","author":"Wills","year":"2013","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2023.10.014_bb0050","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1200\/JCO.2007.14.0566","article-title":"Sentinel node dissection is safe in the treatment of early-stage vulvar cancer","volume":"26","author":"Van der Zee","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ygyno.2023.10.014_bb0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2015.09.077","article-title":"Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational study on sentinel nodes in vulvar cancer (GROINSS-V) I","volume":"140","author":"Te Grootenhuis","year":"2016","journal-title":"Gynecol. Oncol."},{"issue":"32","key":"10.1016\/j.ygyno.2023.10.014_bb0060","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1200\/JCO.21.00006","article-title":"Radiotherapy versus Inguinofemoral lymphadenectomy as treatment for vulvar Cancer patients with micrometastases in the sentinel node: results of GROINSS-V II","volume":"39","author":"Oonk","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.ygyno.2023.10.014_bb0065","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/bjs.4913","article-title":"Co-morbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer","volume":"92","author":"Lemmens","year":"2005","journal-title":"Br. J. Surg."},{"issue":"15","key":"10.1016\/j.ygyno.2023.10.014_bb0070","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.ejca.2007.06.008","article-title":"Comorbidity in older surgical cancer patients: influence on patient care and outcome","volume":"43","author":"Janssen-Heijnen","year":"2007","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0075","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.juro.2010.10.061","article-title":"Comorbidity, treatment and mortality: a population based cohort study of prostate cancer in PCBaSe Sweden","volume":"185","author":"Berglund","year":"2011","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ygyno.2011.02.005","article-title":"Effect of age and comorbidity on the treatment and survival of older patients with vulvar cancer","volume":"121","author":"Ghebre","year":"2011","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.ygyno.2023.10.014_bb0085","article-title":"Frailty and treatment decisions in older patients with vulvar cancer: a single-center cohort study","volume":"14","author":"Gans","year":"2023","journal-title":"J. Geriatric Oncol."},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.critrevonc.2005.04.008","article-title":"Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach","volume":"55","author":"Janssen-Heijnen","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"5","key":"10.1016\/j.ygyno.2023.10.014_bb0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"issue":"3","key":"10.1016\/j.ygyno.2023.10.014_bb0100","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ygyno.2020.09.027","article-title":"Primary treatment and relative survival by stage and age in vulvar squamous cell carcinoma: a population-based SweGCG study","volume":"159","author":"Hellman","year":"2020","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2023.10.014_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/1471-0528.12580","article-title":"Management and outcomes for elderly women with vulvar cancer over time","volume":"121","author":"Rauh-Hain","year":"2014","journal-title":"BJOG"},{"issue":"12","key":"10.1016\/j.ygyno.2023.10.014_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122081","article-title":"Changes in the Clinicopathological demographics of vulvar Cancer in Japan: increasing oldest-old, stage shifting, and decreasing cohort-level survival (dagger)","volume":"8","author":"Nishio","year":"2019","journal-title":"J. Clin. Med."},{"issue":"7","key":"10.1016\/j.ygyno.2023.10.014_bb0115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S1470-2045(10)70104-2","article-title":"Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study","volume":"11","author":"Oonk","year":"2010","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.ygyno.2023.10.014_bb0120","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/ijgc-2019-000489","article-title":"Treatment patterns and associated factors in patients with advanced epithelial ovarian cancer: a population-based study","volume":"29","author":"Zijlstra","year":"2019","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"4","key":"10.1016\/j.ygyno.2023.10.014_bb0125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40801-018-0145-x","article-title":"Impact of age, comorbidity, and FIGO stage on treatment choice and mortality in older Danish patients with gynecological cancer: a retrospective register-based cohort study","volume":"5","author":"Nadaraja","year":"2018","journal-title":"Drugs Real World Outcom."},{"issue":"2","key":"10.1016\/j.ygyno.2023.10.014_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.21608\/jcbr.2022.115165.1242","article-title":"Predicting causes of death among vulvar cancer patients; SEER database analysis","volume":"6","author":"Hafez","year":"2022","journal-title":"Int. J. Cancer Biomed. Res."},{"issue":"6","key":"10.1016\/j.ygyno.2023.10.014_bb0135","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/ijgc-2021-003211","article-title":"Prognostic nomograms to predict overall survival and cause specific death in vulvar squamous cell carcinoma","volume":"32","author":"Mao","year":"2022","journal-title":"Int. J. Gynecolog. Cancer"},{"issue":"1","key":"10.1016\/j.ygyno.2023.10.014_bb0140","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2019.30.e6","article-title":"The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients","volume":"30","author":"Di Donato","year":"2019","journal-title":"J. Gynecol. Oncol."}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009082582301507X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009082582301507X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:05:59Z","timestamp":1758773159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009082582301507X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":28,"alternative-id":["S009082582301507X"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2023.10.014","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vulvar squamous cell carcinoma in women 80\u00a0years and older: Treatment, survival and impact of comorbidities","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2023.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}