{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:29:44Z","timestamp":1794475784584,"version":"4.9.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002918","name":"Gentofte Hospital","doi-asserted-by":"publisher","award":["CA125"],"award-info":[{"award-number":["CA125"]}],"id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008273","name":"\u00d8jenfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032682","name":"Department of Clinical Biochemistry, Aarhus University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032682","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ygyno.2026.05.005","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:13:48Z","timestamp":1778811228000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adding HE4 to the IOTA ADNEX model for differentiating adnexal masses: A Danish prospective, multicenter study"],"prefix":"10.1016","volume":"209","author":[{"given":"Nikoline Schou","family":"Karlsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Kim","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Dreisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelone Elisabeth","family":"Sakse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Alexander","family":"Gerds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Frikke-Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid Solyom","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Aarenstrup","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2026.05.005_bb0005","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/AOG.0b013e318298def5","article-title":"Frequency and disposition of ovarian abnormalities followed with serial transvaginal ultrasonography","volume":"122","author":"Pavlik","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0010","series-title":"Pathol. Genet. Tumours Breast Female Genit. Organs","article-title":"Chapter 2. Tumours of the ovary and peritoneum","author":"Tavalossi","year":"2003"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejca.2016.01.007","article-title":"Subjective assessment versus ultrasound models to diagnose ovarian cancer: a systematic review and meta-analysis","volume":"58","author":"Meys","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1148\/radiol.2019191150","article-title":"O-RADS US risk stratification and management system: a consensus guideline from the ACR ovarian-adnexal reporting and data system committee","volume":"294","author":"Andreotti","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0025","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/ijgc-2021-002565","article-title":"ESGO\/ISUOG\/IOTA\/ESGE consensus statement on pre-operative diagnosis of ovarian tumors","volume":"31","author":"Timmerman","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0030","doi-asserted-by":"crossref","first-page":"E363","DOI":"10.1503\/cmaj.220637","article-title":"Diagnosis and management of endometriosis","volume":"195","author":"Allaire","year":"2023","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0035","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/uog.15955","article-title":"Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the international deep endometriosis analysis (IDEA) group","volume":"48","author":"Guerriero","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ygyno.2016.05.005","article-title":"Relapse and disease specific survival in 1143 Danish women diagnosed with borderline ovarian tumours (BOT)","volume":"142","author":"Karlsen","year":"2016","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0045","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ygyno.2022.01.003","article-title":"Impact of care by gynecologic oncologists on primary ovarian cancer survival: A population-based study","volume":"164","author":"Bouchard-Fortier","year":"2022","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0050","first-page":"no","article-title":"Centralized treatment of advanced stages of ovarian cancer improves survival: A nationwide Danish survey","volume":"90","author":"Fag\u00f6-Olsen","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0055","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1634\/theoncologist.2012-0139","article-title":"Diagnosis, treatment, and follow-up of borderline ovarian tumors","volume":"17","author":"Fischerova","year":"2012","journal-title":"Oncologist"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0065","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/humupd\/dmt059","article-title":"Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: a systematic review and meta-analysis","volume":"20","author":"Kaijser","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0070","author":"Danish Health Authority [Sundhedsstyrelsen]"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0075","series-title":"Guidelines - Ovarian Cancer ('Retningslinier - ovariecancer\u2019)","author":"D.G.C.G. (DGCG)","year":"2014"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0080","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1471-0528.1990.tb02448.x","article-title":"A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer","volume":"97","author":"Jacobs","year":"1990","journal-title":"BJOG"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0085","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1469-0705.2000.00287.x","article-title":"International ovarian tumor analysis (IOTA) group, terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the international ovarian tumor analysis (IOTA) group","volume":"16","author":"Timmerman","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0090","doi-asserted-by":"crossref","first-page":"g5920","DOI":"10.1136\/bmj.g5920","article-title":"Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: Prospective multicentre diagnostic study","volume":"349","author":"Van Calster","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14153621","article-title":"Diagnostic models combining clinical information, ultrasound and biochemical markers for ovarian cancer: Cochrane systematic review and meta-analysis","volume":"14","author":"Davenport","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0100","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstr\u00f6m","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ygyno.2018.08.025","article-title":"A multicenter clinical trial validating the performance of HE4, CA125, risk of ovarian malignancy algorithm and risk of malignancy index","volume":"151","author":"Lycke","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0130","article-title":"Performance of the IOTA ADNEX model combined with HE4 for identifying early-stage ovarian cancer","volume":"12","author":"Yang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.ygyno.2026.05.005_bb0135","unstructured":"The Danish Cancer Biobank, (n.d.). https:\/\/www.rbgb.dk\/en\/om-rbgb\/ (accessed February 26, 2025)."},{"key":"10.1016\/j.ygyno.2026.05.005_bb0140","unstructured":"Rest of the World Products: EIA Kits: HE4. (n.d.). http:\/\/www.fdi.com\/world_home\/products\/manual_kits\/eia_kits\/he4.html (accessed January 8, 2017)."},{"key":"10.1016\/j.ygyno.2026.05.005_bb0145","unstructured":"Rest of the World Products: EIA Kits: CanAg CA125. (n.d.). http:\/\/www.fdi.com\/world_home\/products\/manual_kits\/eia_kits\/canag_ca125.html (accessed January 8, 2017)."},{"key":"10.1016\/j.ygyno.2026.05.005_bb0150","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2023-000817","article-title":"ADNEX risk prediction model for diagnosis of ovarian cancer: systematic review and meta-analysis of external validation studies","volume":"3","author":"Barre\u00f1ada","year":"2024","journal-title":"BMJ Med"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825826019773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825826019773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:00:28Z","timestamp":1794474028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825826019773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":25,"alternative-id":["S0090825826019773"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2026.05.005","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adding HE4 to the IOTA ADNEX model for differentiating adnexal masses: A Danish prospective, multicenter study","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2026.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}