{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:25:56Z","timestamp":1794266756369,"version":"4.9.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005362","name":"University of Bari Aldo Moro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gynecologiconcology-online.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ygyno.2026.06.013","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:00:31Z","timestamp":1781884831000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Occult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1\/2 carriers: A multicenter retrospective cohort study"],"prefix":"10.1016","volume":"211","author":[{"given":"Mauro Francesco Pio","family":"Maiorano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Cormio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"De Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Pia","family":"Torzillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"Ramunno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Pilato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Mongelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Carella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Naglieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigida Anna","family":"Maiorano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Silvestris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Loizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygyno.2026.06.013_bb0005","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","article-title":"Linkage of early-onset familial breast cancer to chromosome 17q21","volume":"250","author":"Hall","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1294-399","article-title":"Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families","volume":"8","author":"Friedman","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.7939630","article-title":"BRCA1 mutations in primary breast and ovarian carcinomas","volume":"266","author":"Futreal","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0025","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1126\/science.8091231","article-title":"Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13","volume":"265","author":"Wooster","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0035","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.4065\/mcp.2010.0414","article-title":"Identification and management of women with BRCA mutations or hereditary predisposition for breast and ovarian cancer","volume":"85","author":"Pruthi","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ygyno.2005.05.002","article-title":"Society of Gynecologic Oncologists Clinical Practice Committee statement on prophylactic salpingo-oophorectomy","volume":"98","author":"Society of Gynecologic Oncologists Clinical Practice Committee","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0045","author":"National Comprehensive Cancer Network"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.annonc.2023.11.015","article-title":"ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease","volume":"35","author":"Ledermann","year":"2024","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0055","article-title":"Risk-reducing salpingo-oophorectomy and breast cancer risk reduction in the gynecologic oncology group Protocol-0199 (GOG-0199)","volume":"4","author":"Mai","year":"2019","journal-title":"JNCI Cancer Spectr."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0060","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/ijgo.70110","article-title":"Pathology results of risk-reducing salpingo-oophorectomy in BRCA1\/2 carriers and long-term clinical outcomes","volume":"170","author":"Assaf","year":"2025","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0065","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1200\/JCO.21.02016","article-title":"Risk of peritoneal carcinomatosis after risk-reducing salpingo-oophorectomy: a systematic review and individual patient data meta-analysis","volume":"40","author":"Steenbeek","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0070","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/PAS.0b013e31819e986a","article-title":"Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma","volume":"33","author":"Rabban","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fonc.2016.00108","article-title":"Ovarian cancer: the fallopian tube as the site of origin and opportunities for prevention","volume":"6","author":"George","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0080","article-title":"Serous tubal intraepithelial carcinoma (STIC): a review of the literature on the incidence at the time of prophylactic surgery","volume":"14","author":"Luvero","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0085","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ygyno.2014.07.084","article-title":"A cautious view of putative precursors of serous carcinomas in the fallopian tubes of BRCA mutation carriers","volume":"134","author":"Cass","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/126295","article-title":"Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics","volume":"2010","author":"Gross","year":"2010","journal-title":"J. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0095","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/PGP.0000000000000604","article-title":"An alternate diagnostic algorithm for the diagnosis of intraepithelial fallopian tube lesions","volume":"39","author":"Perrone","year":"2020","journal-title":"Int. J. Gynecol. Pathol."},{"issue":"Suppl. 2","key":"10.1016\/j.ygyno.2026.06.013_bb0100","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s13224-018-1155-z","article-title":"Evaluation of SEE-FIM (sectioning and extensively examining the fimbrated end) protocol in identifying fallopian tube precursor lesions in women with ovarian tumors","volume":"69","author":"Arora","year":"2019","journal-title":"J. Obstet. Gynaecol. India"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygyno.2026.02.019","article-title":"Peritoneal cancer risk after risk-reducing salpingo-oophorectomy, impact of mutational status and STIC lesions","volume":"208","author":"Saule","year":"2026","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0110","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1055\/a-1545-4279","article-title":"2020 WHO classification of female genital tumors","volume":"81","author":"H\u00f6hn","year":"2021","journal-title":"Geburtshilfe Frauenheilkd."},{"issue":"Suppl. 1","key":"10.1016\/j.ygyno.2026.06.013_bb0115","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1097\/PGP.0000000000000908","article-title":"Data set for the reporting of ovarian, fallopian tube and primary peritoneal carcinoma: recommendations from the international collaboration on Cancer reporting (ICCR)","volume":"41","author":"Gilks","year":"2022","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/PGP.0b013e31823b8831","article-title":"Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma","volume":"31","author":"Vang","year":"2012","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/his.14902","article-title":"Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study","volume":"83","author":"Bogaerts","year":"2023","journal-title":"Histopathology"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0130","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ygyno.2016.08.336","article-title":"Occult and subsequent cancer incidence following risk-reducing surgery in BRCA mutation carriers","volume":"143","author":"Zakhour","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2478\/raon-2020-0020","article-title":"The prevalence of occult ovarian cancer in the series of 155 consequently operated high risk asymptomatic patients - population based study","volume":"54","author":"Gornjec","year":"2020","journal-title":"Radiol. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0145","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00428-021-03244-w","article-title":"Recommendations for diagnosing STIC: a systematic review and meta-analysis","volume":"480","author":"Bogaerts","year":"2022","journal-title":"Virchows Arch."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0150","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1158\/1940-6207.CAPR-18-0009","article-title":"Fallopian tube lesions in women at high risk for ovarian cancer: a multicenter study","volume":"11","author":"Visvanathan","year":"2018","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0155","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1200\/JCO.22.01237","article-title":"High-grade serous carcinoma at risk-reducing salpingo-oophorectomy in asymptomatic carriers of BRCA1\/2 pathogenic variants: prevalence and clinical factors","volume":"41","author":"Stroot","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ejhg.2010.203","article-title":"On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations","volume":"19","author":"Hamel","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ygyno.2026.06.013_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184714","article-title":"Spectrum of germline pathogenic variants in BRCA1\/2 genes in the Apulian southern Italy population: geographic distribution and evidence for targeted genetic testing","volume":"13","author":"Patruno","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0170","doi-asserted-by":"crossref","first-page":"22353","DOI":"10.18632\/oncotarget.24959","article-title":"BRCAmut and \u201cfounder effect\u201d: a prospective study in a single academic institution","volume":"9","author":"Loizzi","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14020365","article-title":"Beyond BRCA1\/2: homologous recombination repair genetic profile in a large cohort of Apulian ovarian cancers","volume":"14","author":"Turchiano","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ygyno.2026.06.013_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051158","article-title":"Hereditary breast and ovarian cancer in families from southern Italy (Sicily): prevalence and geographic distribution of pathogenic variants in BRCA1\/2 genes","volume":"12","author":"Incorvaia","year":"2020","journal-title":"Cancers (Basel)"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825826020330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825826020330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:35:59Z","timestamp":1786149359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825826020330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"alternative-id":["S0090825826020330"],"URL":"https:\/\/doi.org\/10.1016\/j.ygyno.2026.06.013","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Occult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1\/2 carriers: A multicenter retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygyno.2026.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}