{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:36:21Z","timestamp":1790501781249,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.yhbeh.2006.03.009","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T12:50:35Z","timestamp":1146660635000},"page":"261-265","source":"Crossref","is-referenced-by-count":24,"title":["Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive\u2013behavioral treatment in patients with bulimia nervosa"],"prefix":"10.1016","volume":"50","author":[{"given":"Muneki","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Muranaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2006.03.009_bib1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1176\/ajp.149.1.82","article-title":"Pharmacologic and cognitive\u2013behavioral treatment for bulimia nervosa: a controlled comparison","volume":"149","author":"Agras","year":"1992","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.6166045","article-title":"Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control","volume":"213","author":"Akselrod","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1139\/y90-047","article-title":"The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity","volume":"68","author":"Andrews","year":"1990","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.22158","article-title":"Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin","volume":"120","author":"Asakawa","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib5","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1161\/01.CIR.91.7.1936","article-title":"RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction","volume":"91","author":"Bigger","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib6","first-page":"1029","article-title":"Assessment of human body composition using dual-energy X-ray absorptiometry and bioelectrical impedance analysis","volume":"7","author":"Bolanowski","year":"2001","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0306-4530(00)00016-0","article-title":"Reduced plasma leptin concentrations in bulimia nervosa","volume":"25","author":"Brewerton","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib8","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/gast.2002.35954","article-title":"The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats","volume":"123","author":"Date","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib9","series-title":"Binge Eating: Nature, Assessment and Treatment","first-page":"361","article-title":"Cognitive\u2013behavioral therapy for binge eating and bulimia nervosa: a comprehensive treatment manual","author":"Fairburn","year":"1993"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0304-3940(94)90185-6","article-title":"Inhibition of a 5-HT3 receptor-mediated current by the selective serotonin uptake inhibitor, fluoxetine","volume":"173","author":"Fan","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0306-4522(94)90384-0","article-title":"Facilitation of 5-hydroxytryptamine3 receptor desensitization by fluoxetine","volume":"62","author":"Fan","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0140-6736(99)09062-5","article-title":"Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial","volume":"355","author":"Faris","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.psyneuen.2004.12.008","article-title":"Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa","volume":"30","author":"Fassino","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib14","series-title":"Biometric Research","article-title":"Structured clinical interview for DSM-IV axis I disorders\u2014Patient edition (SCID I\/P, Version 2.0)","author":"First","year":"1995"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/archpsyc.1992.01820020059008","article-title":"Fluoxetine in the treatment of bulimia nervosa","volume":"49","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1176\/ajp.150.5.770","article-title":"Pharmacotherapy of bulimia nervosa with fluoxetine: assessment of clinically significant attitudinal change","volume":"150","author":"Goldbloom","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1192\/bjp.166.5.660","article-title":"Long-term fluoxetine treatment of bulimia nervosa","volume":"166","author":"Goldstein","year":"1995","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib18","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/01.CIR.81.4.1217","article-title":"Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity","volume":"81","author":"Hayano","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/35086018","article-title":"Ghrelin: an orexigenic and somatotrophic signal from the stomach","volume":"2","author":"Inui","year":"2001","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0006-3223(90)90412-U","article-title":"Eating disorders and depression: is there a serotonin connection","volume":"28","author":"Jimerson","year":"1990","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib21","first-page":"4511","article-title":"Decreased serum leptin in bulimia nervosa","volume":"85","author":"Jimerson","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00004850-200209000-00002","article-title":"Discontinuation symptoms: comparison of brief interruption in fluoxetine and paroxetine treatment","volume":"17","author":"Judge","year":"2002","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0022-3956(89)90032-0","article-title":"Cardiac regulation in bulimia nervosa","volume":"23","author":"Kennedy","year":"1989","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib24","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/0028-3908(94)90133-3","article-title":"Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C\/2B receptor function","volume":"33","author":"Kennett","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0361-9230(94)90048-5","article-title":"The central connections of the vagus nerve in the ferret","volume":"33","author":"Knox","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2265.2004.02176.x","article-title":"Altered ghrelin and peptide YY responses to meals in bulimia nervosa","volume":"62","author":"Kojima","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1006\/bbrc.2000.3568","article-title":"Ghrelin stimulates gastric acid secretion and motility in rats","volume":"276","author":"Masuda","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib29","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0006-3223(98)00221-2","article-title":"Salivary gland enlargement and elevated serum amylase in bulimia nervosa","volume":"45","author":"Metzger","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.RES.59.2.178","article-title":"Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog","volume":"59","author":"Pagani","year":"1986","journal-title":"Circ. Res."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1469-8986.1995.tb01213.x","article-title":"Orienting in a defensive world: mammalian modifications of our evolutionary heritage. A polyvagal theory","volume":"32","author":"Porges","year":"1995","journal-title":"Psychophysiology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00004714-199802000-00005","article-title":"Fluoxetine normalizes increased cardiac vagal tone in bulimia nervosa","volume":"18","author":"Rissanen","year":"1998","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/jcem.87.1.8129","article-title":"Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion","volume":"87","author":"Shiiya","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2337\/diabetes.50.2.227","article-title":"Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y\/Y1 receptor pathway","volume":"50","author":"Shintani","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S003329179900313X","article-title":"Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa","volume":"31","author":"Steiger","year":"2001","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib37","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1210\/jcem.85.12.7167","article-title":"Ghrelin strongly stimulates growth hormone release in humans","volume":"85","author":"Takaya","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib38","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/eje.0.146R001","article-title":"Increased fasting plasma ghrelin levels in patients with bulimia nervosa","volume":"146","author":"Tanaka","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-3956(02)00067-5","article-title":"Habitual binge\/purge behavior influences circulating ghrelin levels in eating disorders","volume":"37","author":"Tanaka","year":"2003","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib40","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0306-4530(02)00066-5","article-title":"Fasting plasma ghrelin levels in subtypes of anorexia nervosa","volume":"28","author":"Tanaka","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib41","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1046\/j.1365-2265.2003.01886.x","article-title":"Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa","volume":"59","author":"Tanaka","year":"2003","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.regpep.2004.06.015","article-title":"Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa","volume":"122","author":"Tanaka","year":"2004","journal-title":"Regul. Pept."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib43","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tsch\u00f6p","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00213-002-1378-6","article-title":"Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28\u00a0days as a result of maintained hypophagia","volume":"167","author":"Vickers","year":"2003","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1176\/ajp.154.4.523","article-title":"Medication and psychotherapy in the treatment of bulimia nervosa","volume":"154","author":"Walsh","year":"1997","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2006.03.009_bib46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/eat.1086","article-title":"Laboratory screening for electrolyte abnormalities and anemia in bulimia nervosa: a controlled study","volume":"30","author":"Wolfe","year":"2001","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.yhbeh.2006.03.009_bib47","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1210\/jcem.86.12.8111","article-title":"Ghrelin enhances appetite and increases food intake in humans","volume":"86","author":"Wren","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X06000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X06000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T21:26:49Z","timestamp":1547674009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X06000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0018506X06000602"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2006.03.009","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}