{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:04:14Z","timestamp":1793333054571,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.yhbeh.2008.03.012","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T13:19:47Z","timestamp":1207747187000},"page":"347-354","source":"Crossref","is-referenced-by-count":74,"title":["Reverse engineering the lordosis behavior circuit"],"prefix":"10.1016","volume":"54","author":[{"given":"D.W.","family":"Pfaff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-M.","family":"Kow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Loose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"Flanagan-Cato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2008.03.012_bib1","series-title":"Reproductive Behavior","article-title":"The behavioral control of reproductive physiology","author":"Adler","year":"1974"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ar.1090790405","article-title":"The length of heat in the albino rat as determined by the copulatory response","volume":"79","author":"Blandau","year":"1941","journal-title":"Anat. Rec."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib3","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1523\/JNEUROSCI.20-04-01589.2000","article-title":"Estrogen selectively induces dendritic spines within the dendritic arbor of rat ventromedial hypothalamic neurons","volume":"20","author":"Calizo","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cne.10223","article-title":"Estrogen-induced dendritic spine elimination on female rat ventromedial hypothalamic neurons that project to the periaqueductal gray","volume":"447","author":"Calizo","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib5","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1210\/en.2003-0331","article-title":"Hormonal\u2013neural integration in the female rat ventromedial hypothalamus: triple labeling for estrogen receptor-a, retrograde tract tracing from the periaqueductal gray, and mating-induced fos expression","volume":"144","author":"Calizo","year":"2003","journal-title":"Endocrinology."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(82)90218-9","article-title":"Ultrastructural changes in the hypothalamic ventromedial nucleus of ovariectomized rats after estrogen treatment","volume":"240","author":"Carrer","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/BF00247306","article-title":"Estrogen-induced alterations in synaptic morphology in the midbrain central gray","volume":"69","author":"Chung","year":"1988","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib8","doi-asserted-by":"crossref","unstructured":"Cohen, R.S., Pfaff, D.W., 1981. Ultrastructure of neurons in the ventromedial nucleus of the hypothalamus in ovariectomized rats with or without estrogen treatment.","DOI":"10.1007\/BF00219357"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1530\/jrf.0.1020451","article-title":"Influence of paced mating and number of intromissions on fertility in the laboratory rat","volume":"102","author":"Coopersmith","year":"1994","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib10","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.1069981","article-title":"Reverse engineering of biological complexity","volume":"295","author":"Csete","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-4695(200010)45:1<1::AID-NEU1>3.0.CO;2-W","article-title":"Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats","volume":"45","author":"Daniels","year":"2000","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.arr.2003.08.006","article-title":"How bioinformatics can help reverse engineer human aging","volume":"3","author":"de Magalhaes","year":"2004","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1385\/ENDO:27:3:253","article-title":"Potentiation of genomic actions of estrogen by membrane actions in MCF-7 cells and the involvement of protein kinase C activation","volume":"27","author":"Devidze","year":"2005","journal-title":"Endocrine."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000126562","article-title":"Induction of Fos immunoreactivity in oxytocin neurons after sexual activity in female rats","volume":"58","author":"Flanagan","year":"1993","journal-title":"Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1365-2826.2006.01483.x","article-title":"Sexual behavior induces the expression of activity-regulated cytoskeletal protein (Arc) and modifies neuronal morphology in the female rat ventromedial nucleus","volume":"18","author":"Flanagan-Cato","year":"2006","journal-title":"J. Neuroendocrinology."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1037\/h0077360","article-title":"Communication among hamsters by high-frequency acoustic signals: III. Responses evoked by natural and synthetic ultrasounds","volume":"91","author":"Floody","year":"1977","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/00001756-199107000-00006","article-title":"Estrogen increases axodendritic synapses in the VMN of rats after ovariectomy","volume":"2","author":"Frankfurt","year":"1991","journal-title":"NeuroReport."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib18","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1159\/000125387","article-title":"Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a golgi study in the adult rat","volume":"51","author":"Frankfurt","year":"1990","journal-title":"Neuroendocrinology."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pbb.2006.02.016","article-title":"Role of glutamate receptors in the ventromedial hypothlamus in the regulation of female rat sexual behaviors. I. Behavioral effects of glutamate and its receptor agonists, AMPA, NMDA and kainate","volume":"83","author":"Georgescu","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib20","first-page":"341","article-title":"Functional peptides by genome reverse engineering","volume":"10","author":"Grigorov","year":"2007","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib21","doi-asserted-by":"crossref","first-page":"12354","DOI":"10.1073\/pnas.0404889101","article-title":"The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions","volume":"101","author":"Kow","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0149-7634(94)90028-0","article-title":"Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review","volume":"18","author":"Kow","year":"1994","journal-title":"Neurosci. Biobehav. Rev"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2005.02.068","article-title":"Acute estrogen potentiates excitatory responses of neurons in rat hypothalamic ventromedial nucleus","volume":"1043","author":"Kow","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.07.104","article-title":"Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus","volume":"1116","author":"Kow","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib40","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1210\/endo-107-6-1782","article-title":"In vivo release of luteinizing hormone-releasing hormone estimated with push-pull cannulae from the mediobasal hypothalami of ovariectomized, steroid-primed rats","volume":"107","author":"Levine","year":"1980","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.mp.4001493","article-title":"Hormonal symphony: steroid orchestration of gene modules for sociosexual behaviors","volume":"9","author":"Mong","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib26","doi-asserted-by":"crossref","first-page":"10456","DOI":"10.1073\/pnas.0603045103","article-title":"RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors","volume":"103","author":"Musatov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib27","series-title":"Estrogens and Brain Function","author":"Pfaff","year":"1980"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib28","series-title":"The M.I.T","article-title":"Drive: Molecular and physiological analyses of a simple reproductive behavior","author":"Pfaff","year":"1999"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0018-506X(74)90018-X","article-title":"Film analyses of lordosis in female rats","volume":"5","author":"Pfaff","year":"1974","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0361-9230(97)00219-0","article-title":"Implications of immediate early gene induction in the brain following sexual stimulation of female and male rodents","volume":"44","author":"Pfaus","year":"1997","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib31","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1037\/h0077361","article-title":"Communication among hamsters by high-frequency acoustic signals: II. Determinants of calling by females and males","volume":"91","author":"Pfaff","year":"1977","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1979.sp012690","article-title":"Deficit in the lordosis reflex of female rats caused by lesions in the ventromedial nucleus of the hypothalamus","volume":"288","author":"Pfaff","year":"1979","journal-title":"J. Physiol."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-8993(93)90085-2","article-title":"Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain","volume":"624","author":"Pfaus","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/hbeh.1999.1516","article-title":"Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. I. A correlational and factor analysis and the effects of ovarian hormones","volume":"35","author":"Pfaus","year":"1999","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(85)91624-5","article-title":"Inhibition of sexual receptivity by anesthesia during estrogen priming","volume":"337","author":"Roy","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib36","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1194\/jlr.R600026-JLR200","article-title":"Reverse engineering gene networks to identify key drivers of complex disease phenotypes","volume":"47","author":"Schadt","year":"2006","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.yhbeh.2008.03.012_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2005-0021","article-title":"Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles","volume":"28","author":"Vasudevan","year":"2007","journal-title":"Endocrine Rev."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib38","doi-asserted-by":"crossref","first-page":"12267","DOI":"10.1073\/pnas.221449798","article-title":"Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line","volume":"98","author":"Vasudevan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2008.03.012_bib39","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.steroids.2005.02.007","article-title":"Integration of steroid hormone initiated membrane action to genomic function in the brain","volume":"70","author":"Vasudevan","year":"2005","journal-title":"Steroids"}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X08000962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X08000962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:24:25Z","timestamp":1684337065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X08000962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0018506X08000962"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2008.03.012","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}