{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:09:24Z","timestamp":1789409364799,"version":"build-2803163510"},"reference-count":126,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.yhbeh.2012.02.020","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T10:03:51Z","timestamp":1330164231000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Melatonin and mitochondrial dysfunction in the central nervous system"],"prefix":"10.1016","volume":"63","author":[{"given":"Daniel P.","family":"Cardinali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora S.","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Scacchi Bernasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Reynoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Scacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2012.02.020_bb0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1034\/j.1600-079X.2000.290106.x","article-title":"Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of complex I of the mitochondrial respiratory chain","volume":"29","author":"Absi","year":"2000","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/156802611794863517","article-title":"Melatonin-mitochondria interplay in health and disease","volume":"11","author":"Acu\u00f1a Castroviejo","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0015","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0020","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.03-1031fje","article-title":"Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin","volume":"18","author":"Andrabi","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0025","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1096\/fasebj.10.8.8666165","article-title":"Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes","volume":"10","author":"Antolin","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0040-8166(77)90025-8","article-title":"Effect of melatonin implants on gonadal weights and pineal gland fine structure of the golden hamster","volume":"9","author":"Barratt","year":"1977","journal-title":"Tissue Cell"},{"issue":"Suppl. 3","key":"10.1016\/j.yhbeh.2012.02.020_bb0035","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1016\/S1353-8020(09)70812-0","article-title":"Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease","volume":"15","author":"Beal","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2005.00282.x","article-title":"Melatonin as a cytoskeletal modulator: implications for cell physiology and disease","volume":"40","author":"Benitez-King","year":"2006","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0635","doi-asserted-by":"crossref","DOI":"10.4061\/2010\/621870","article-title":"Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease","author":"Bobba","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0005-2728(98)00165-0","article-title":"Mitochondrial involvement in Alzheimer's disease","volume":"1410","author":"Bonilla","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0065","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1210\/endo-91-5-1213","article-title":"Binding of melatonin to human and rat plasma proteins","volume":"91","author":"Cardinali","year":"1972","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0060","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/157015910792246209","article-title":"Clinical aspects of melatonin intervention in Alzheimer's disease progression","volume":"8","author":"Cardinali","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0070","doi-asserted-by":"crossref","unstructured":"Cardinali, D. P., Srinivasan, V., Brzezinski, A., Brown, G. M., in press. Melatonin and its analogs in insomnia and depression. J. Pineal Res., Doi:10.1111\/j.1600-079X.2011.00962.x.","DOI":"10.1111\/j.1600-079X.2011.00962.x"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0075","first-page":"423","article-title":"The modulatory role of melatonin on immune responsiveness","volume":"7","author":"Carrillo-Vico","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0080","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-079X.1999.tb00570.x","article-title":"Interactions of melatonin with membrane models: portioning of melatonin in AOT and lecithin reversed micelles","volume":"26","author":"Ceraulo","year":"1999","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0085","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-079X.2010.00752.x","article-title":"Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative\/oxidative stress in patients suffering from Duchenne muscular dystrophy","volume":"48","author":"Chahbouni","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-079X.2009.00704.x","article-title":"Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats","volume":"47","author":"Chang","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0090","article-title":"Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and alpha-synuclein aggregation","author":"Chang","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0100","first-page":"135","article-title":"Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease","volume":"34","author":"Chen","year":"2011","journal-title":"Chang Gung Med. J."},{"issue":"Suppl. 2","key":"10.1016\/j.yhbeh.2012.02.020_bb0105","doi-asserted-by":"crossref","first-page":"S569","DOI":"10.3233\/JAD-2010-100357","article-title":"Role of mitochondrial amyloid-beta in Alzheimer's disease","volume":"20","author":"Chen","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","article-title":"The basic physiology and pathophysiology of melatonin","volume":"9","author":"Claustrat","year":"2005","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0115","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-079X.1998.tb00543.x","article-title":"Protective effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in a non-septic shock model induced by zymosan in the rat","volume":"25","author":"Cuzzocrea","year":"1998","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01243341","article-title":"Stimulatory effects of melatonin on ependymal epithelium of choroid plexuses in golden hamsters","volume":"55","author":"Decker","year":"1982","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.neuro.30.051606.094302","article-title":"Mitochondrial disorders in the nervous system","volume":"31","author":"DiMauro","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-079X.2009.00734.x","article-title":"Differential effects of melatonin on amyloid-beta peptide 25\u201335-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture","volume":"48","author":"Dong","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-079X.2011.00864.x","article-title":"Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling","volume":"51","author":"Dragicevic","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/pr.110.002832","article-title":"International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors","volume":"62","author":"Dubocovich","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2174\/157015910792246155","article-title":"Antiinflammatory activity of melatonin in central nervous system","volume":"8","author":"Esposito","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0150","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s002280000245","article-title":"Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes","volume":"56","author":"Facciola","year":"2001","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.2004.00144.x","article-title":"Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease","volume":"37","author":"Feng","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0165","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1471-4159.2010.06814.x","article-title":"Mitochondrial biology in Alzheimer's disease pathogenesis","volume":"114","author":"Galindo","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0170","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0140-6736(06)68542-5","article-title":"Mild cognitive impairment","volume":"367","author":"Gauthier","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0640","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1196\/annals.1293.010","article-title":"The mitochondrial production of reactive oxygen species in relation to aging and pathology","volume":"1011","author":"Genova","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbadis.2009.08.010","article-title":"Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases","volume":"1802","author":"Gibson","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0185","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1089\/ars.2010.3386","article-title":"Neuronal calcium homeostasis and dysregulation","volume":"14","author":"Gleichmann","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0190","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cell.2008.01.007","article-title":"Mitochondria\u2014a nexus for aging, calorie restriction, and sirtuins?","volume":"132","author":"Guarente","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0195","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1600-079X.2008.00626.x","article-title":"Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model","volume":"45","author":"Gutierrez-Cuesta","year":"2008","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1385\/ENDO:27:2:119","article-title":"Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance","volume":"27","author":"Hardeland","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/biof.23","article-title":"Melatonin: signaling mechanisms of a pleiotropic agent","volume":"35","author":"Hardeland","year":"2009","journal-title":"Biofactors"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0645","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1743-7075-2-22","article-title":"Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug","volume":"2","author":"Hardeland","year":"2005","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1081\/CBI-120025245","article-title":"Circadian rhythms, oxidative stress, and antioxidative defense mechanisms","volume":"20","author":"Hardeland","year":"2003","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00701.x","article-title":"Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines","volume":"47","author":"Hardeland","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0210","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","article-title":"Melatonin\u2014a pleiotropic, orchestrating regulator molecule","volume":"93","author":"Hardeland","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0230","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1067\/mcp.2001.116512","article-title":"Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study","volume":"70","author":"Hartter","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0235","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1073\/pnas.110138997","article-title":"Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy","volume":"97","author":"Heiser","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0240","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1212\/WNL.45.10.1879","article-title":"Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients","volume":"45","author":"Horton","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0245","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.arr.2010.05.003","article-title":"Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease","volume":"9","author":"Hung","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0250","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2005.01.003","article-title":"Melatonin attenuates amyloid beta25\u201335-induced apoptosis in mouse microglial BV2 cells","volume":"380","author":"Jang","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0255","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1179\/135100009X392548","article-title":"24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment","volume":"14","author":"Jimenez-Ortega","year":"2009","journal-title":"Redox Rep."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0260","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-079X.2004.00140.x","article-title":"Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes","volume":"37","author":"Jou","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0265","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-079X.2007.00490.x","article-title":"Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis","volume":"43","author":"Jou","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(00)00568-1","article-title":"Renal toxicity of the carcinogen delta-aminolevulinic acid: antioxidant effects of melatonin","volume":"161","author":"Karbownik","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0275","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2004.09.007","article-title":"Neurochemical properties of ramelteon (TAK-375), a selective MT1\/MT2 receptor agonist","volume":"48","author":"Kato","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0280","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neulet.2008.03.053","article-title":"Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells","volume":"436","author":"Klongpanichapak","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0285","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.amjmed.2003.07.017","article-title":"Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy","volume":"116","author":"Leger","year":"2004","journal-title":"Am. J. Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0290","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death","volume":"1787","author":"Lemasters","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0295","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1089\/ars.2009.2704","article-title":"Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject","volume":"12","author":"Lenaz","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0300","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-079X.2007.00456.x","article-title":"Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein","volume":"43","author":"Lin","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0305","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.freeradbiomed.2010.02.036","article-title":"Mechanism of the peroxidase activity of Cu, Zn superoxide dismutase","volume":"48","author":"Liochev","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0310","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0315","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-079X.2008.00647.x","article-title":"Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production","volume":"46","author":"L\u00f3pez","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0320","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","article-title":"Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study","volume":"364","author":"Luoma","year":"2004","journal-title":"Lancet"},{"issue":"Suppl. 2","key":"10.1016\/j.yhbeh.2012.02.020_bb0325","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons","volume":"20","author":"Manczak","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0330","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1042\/BST0321068","article-title":"Nitric oxide, hypoxia and brain inflammation","volume":"32","author":"Mander","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0335","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.99-0865fje","article-title":"Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress","volume":"14","author":"Martin","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0340","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1034\/j.1600-079X.2000.280407.x","article-title":"Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo","volume":"28","author":"Martin","year":"2000","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0650","doi-asserted-by":"crossref","first-page":"758","DOI":"10.18632\/aging.100088","article-title":"Mitochondrial superoxide: a key player in Alzheimer's disease","volume":"1","author":"Massaad","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0350","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1097\/CCM.0b013e318187b863","article-title":"Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat","volume":"36","author":"Mathes","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0355","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01654.x","article-title":"Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease","volume":"85","author":"Matsubara","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0360","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-079X.1998.tb00395.x","article-title":"Tissue retention and subcellular distribution of continuously infused melatonin in rats under near physiological conditions","volume":"25","author":"Messner","year":"1998","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0365","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.103.051797","article-title":"The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways","volume":"306","author":"Millan","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0370","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1755-5949.2008.00066.x","article-title":"Pharmacology of ramelteon, a selective MT1\/MT2 receptor agonist: a novel therapeutic drug for sleep disorders","volume":"15","author":"Miyamoto","year":"2009","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0375","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.lfs.2004.03.023","article-title":"A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin","volume":"75","author":"Mulchahey","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0380","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12035-010-8141-5","article-title":"Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease\u2014therapeutic aspects","volume":"41","author":"Muller","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0655","article-title":"Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease","volume":"2","author":"Navarro","year":"2010","journal-title":"Front. Aging Neurosci ."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0390","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1600-079X.2009.00692.x","article-title":"Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease","volume":"47","author":"Olcese","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.06741.x","article-title":"Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum","volume":"114","author":"Oliveira","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0400","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2174\/138945011795528895","article-title":"Techniques to investigate neuronal mitochondrial function and its pharmacological modulation","volume":"12","author":"Oliveira","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0405","article-title":"Effect of melatonin on alpha-synuclein self-assembly and cytotoxicity","author":"Ono","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0410","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0197-0186(97)00043-0","article-title":"Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light","volume":"32","author":"Pablos","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0415","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-079X.2010.00759.x","article-title":"Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease","volume":"48","author":"Paradies","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0420","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1089\/rej.2008.0772","article-title":"Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection","volume":"11","author":"Petrosillo","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0425","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1111\/j.1742-4658.2010.07754.x","article-title":"Calcium-dependent mitochondrial function and dysfunction in neurons","volume":"277","author":"Pivovarova","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0430","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainres.2005.01.023","article-title":"Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials","volume":"1037","author":"Quinn","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0435","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0968-0004(00)01674-1","article-title":"Mitochondria, oxygen free radicals, disease and ageing","volume":"25","author":"Raha","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0440","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0140-6736(08)61812-7","article-title":"Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials","volume":"373","author":"Rajaratnam","year":"2009","journal-title":"Lancet"},{"issue":"Suppl. 2","key":"10.1016\/j.yhbeh.2012.02.020_bb0445","doi-asserted-by":"crossref","first-page":"S499","DOI":"10.3233\/JAD-2010-100504","article-title":"Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline","volume":"20","author":"Reddy","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0450","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10409230903044914","article-title":"Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin","volume":"44","author":"Reiter","year":"2009","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0455","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00726-005-0280-z","article-title":"Effect of melatonin treatment on oxygen consumption by rat liver mitochondria","volume":"31","author":"Reyes Toso","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0460","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s11064-008-9865-8","article-title":"Mitochondrial dysfunction and psychiatric disorders","volume":"34","author":"Rezin","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1600-079X.2003.00092.x","article-title":"Regulation of antioxidant enzymes: a significant role for melatonin","volume":"36","author":"Rodriguez","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0470","doi-asserted-by":"crossref","first-page":"e4913","DOI":"10.1371\/journal.pone.0004913","article-title":"Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder","volume":"4","author":"Rollins","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0475","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-079X.2011.00927.x","article-title":"Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats","volume":"52","author":"Sae-Ung","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0480","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00018-003-2319-1","article-title":"Melatonin and cell death: differential actions on apoptosis in normal and cancer cells","volume":"60","author":"Sainz","year":"2003","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0485","first-page":"570","article-title":"Alzheimer's disease: diverse aspects of mitochondrial malfunctioning","volume":"3","author":"Santos","year":"2010","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0490","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1586\/epr.10.50","article-title":"Misfolded proteins and neurodegeneration: role of non-native cytochrome c in cell death","volume":"7","author":"Santucci","year":"2010","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0495","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0005-2728(98)00164-9","article-title":"Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia","volume":"1410","author":"Schapira","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0500","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","article-title":"Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP","volume":"318","author":"Schober","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0505","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molmed.2010.04.007","article-title":"Therapeutic prospects for mitochondrial disease","volume":"16","author":"Schon","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0510","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/1756285611406166","article-title":"Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection","volume":"4","author":"Srinivasan","year":"2011","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0515","first-page":"1","article-title":"Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value","volume":"2011","author":"Srinivasan","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0520","first-page":"1","article-title":"Melatonin in mitochondrial dysfunction and related disorders","volume":"2011","author":"Srinivasan","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0525","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00726-003-0011-2","article-title":"Free radical-mediated oxidation of free amino acids and amino acid residues in proteins","volume":"25","author":"Stadtman","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0530","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1600-079X.2009.00706.x","article-title":"Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway","volume":"47","author":"Tajes","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0535","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/carcin\/15.2.215","article-title":"Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole","volume":"15","author":"Tan","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0540","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","article-title":"One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?","volume":"42","author":"Tan","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0545","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1002\/jnr.22123","article-title":"Melatonin and its brain metabolite N1-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice","volume":"87","author":"Tapias","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0550","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1742-4658.2008.06302.x","article-title":"Parkinson's disease: genetic versus toxin-induced rodent models","volume":"275","author":"Terzioglu","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0555","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10863-011-9337-8","article-title":"Influence of aging on membrane permeability transition in brain mitochondria","volume":"43","author":"Toman","year":"2011","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0560","unstructured":"Trancikova, A., Tsika, E., Moore, D. J., in press. Mitochondrial dysfunction in genetic animal models of Parkinson's disease. Antioxid. Redox. Signal."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0565","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-079X.2004.00163.x","article-title":"Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease","volume":"37","author":"Tunez","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0570","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.sleep.2004.07.009","article-title":"Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists","volume":"5","author":"Turek","year":"2004","journal-title":"Sleep Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0575","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0891-5849(99)00131-8","article-title":"Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells","volume":"27","author":"Urata","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0580","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jps.10348","article-title":"Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist","volume":"92","author":"Vachharajani","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0585","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-079X.2011.00931.x","article-title":"Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations","volume":"52","author":"Venegas","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0590","first-page":"108","article-title":"Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation","volume":"74","author":"Voordouw","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0595","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000123997","article-title":"Bioavailability of oral melatonin in humans","volume":"39","author":"Waldhauser","year":"1984","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0605","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0600","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer's disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0610","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-079X.2006.00377.x","article-title":"Reduced oxidative damage in ALS by high-dose enteral melatonin treatment","volume":"41","author":"Weishaupt","year":"2006","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0615","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1177\/0269881110379307","article-title":"British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders","volume":"24","author":"Wilson","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0620","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/jmcc.2001.1485","article-title":"Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential","volume":"34","author":"Xu","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0625","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1210\/jcem.86.10.7901","article-title":"Melatonin treatment for age-related insomnia","volume":"86","author":"Zhdanova","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yhbeh.2012.02.020_bb0630","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-079X.2008.00570.x","article-title":"Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1\u201342","volume":"45","author":"Zhou","year":"2008","journal-title":"J. Pineal Res."}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X12000517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X12000517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:34:57Z","timestamp":1758069297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X12000517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0018506X12000517"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2012.02.020","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin and mitochondrial dysfunction in the central nervous system","name":"articletitle","label":"Article Title"},{"value":"Hormones and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yhbeh.2012.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}