{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:18:15Z","timestamp":1790162295972,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"am","delay-in-days":337,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006346","name":"Hope for Depression Research Foundation","doi-asserted-by":"publisher","award":["RGA# DTF Phase II (D) (McEwen- PI)"],"award-info":[{"award-number":["RGA# DTF Phase II (D) (McEwen- PI)"]}],"id":[{"id":"10.13039\/100006346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"NIDA","doi-asserted-by":"publisher","award":["5 P01 DA021633"],"award-info":[{"award-number":["5 P01 DA021633"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"ONR","doi-asserted-by":"publisher","award":["N00014-09-1-0598"],"award-info":[{"award-number":["N00014-09-1-0598"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"ONR","doi-asserted-by":"publisher","award":["N00014-12-1-0366"],"award-info":[{"award-number":["N00014-12-1-0366"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pritzker Neuropsychiatric Disorders Research Consortium"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.yhbeh.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T13:42:13Z","timestamp":1475242933000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups"],"prefix":"10.1016","volume":"86","author":[{"given":"Yoav","family":"Litvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cortney A.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel B.","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M.","family":"Maras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sraboni","family":"Chaudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam R.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Peter","family":"Blandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Stanley J.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Akil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"McEwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2016.09.009_bb0005","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0306-4522(97)00560-5","article-title":"The neuronal organization of the supracapsular part of the stria terminalis in the rat: the dorsal component of the extended amygdala","volume":"84","author":"Alheid","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neuroscience.2010.05.023","article-title":"Oxytocin and same-sex social behavior in female meadow voles","volume":"169","author":"Beery","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0020","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.yhbeh.2014.03.008","article-title":"Chronic enhancement of brain oxytocin levels causes enduring anti-aggressive and pro-social explorative behavioral effects in male rats","volume":"65","author":"Calcagnoli","year":"2014","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbr.2013.12.050","article-title":"Local oxytocin expression and oxytocin receptor binding in the male rat brain is associated with aggressiveness","volume":"261","author":"Calcagnoli","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0893-133X(99)00110-4","article-title":"The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat","volume":"22","author":"Caldji","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbr.2006.08.025","article-title":"Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?","volume":"176","author":"Carter","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0040","doi-asserted-by":"crossref","first-page":"11834","DOI":"10.1073\/pnas.1411618111","article-title":"FGF2 is a target and a trigger of epigenetic mechanisms associated with differences in emotionality: partnership with H3K9me3","volume":"111","author":"Chaudhury","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/npp.2009.109","article-title":"Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety","volume":"35","author":"Davis","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0060","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/hipo.20862","article-title":"Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling","volume":"22","author":"Eiland","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0065","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.npp.1301206","article-title":"The interface of oxytocin-labeled cells and serotonin transporter-containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?","volume":"32","author":"Emiliano","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/0470010703.ch13","article-title":"Vasopressin\/oxytocin and aggression","volume":"268","author":"Ferris","year":"2005","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0361-9230(00)00342-7","article-title":"Diazepam induces FGF-2 mRNA in the hippocampus and striatum","volume":"53","author":"Gomez-Pinilla","year":"2000","journal-title":"Brain Res. Bull."},{"issue":"1-2","key":"10.1016\/j.yhbeh.2016.09.009_bb0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0006-8993(95)01002-X","article-title":"A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain","volume":"701","author":"Gonzalez","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0079-6123(08)00428-7","article-title":"Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans","volume":"170","author":"Heinrichs","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0110","article-title":"Ultrasonic vocalizations in rat and mouse pups","author":"Hofer","year":"2002","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1105636","article-title":"Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala","volume":"308","author":"Huber","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0014-2999(91)90806-2","article-title":"Central administration of oxytocin modulates the infant rat's response to social isolation","volume":"203","author":"Insel","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0130","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12041","article-title":"Distinct extended amygdala circuits for divergent motivational states","volume":"496","author":"Jennings","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/REVNEURO.2000.11.4.383","article-title":"Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?","volume":"11","author":"Lehmann","year":"2000","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0150","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.yhbeh.2006.06.028","article-title":"Neuropeptidergic regulation of affiliative behavior and social bonding in animals","volume":"50","author":"Lim","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0155","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuropharm.2009.06.020","article-title":"Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats","volume":"58","author":"Lukas","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2011.95","article-title":"The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice","author":"Lukas","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0175","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1523\/JNEUROSCI.1614-04.2004","article-title":"Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety","volume":"24","author":"Murgatroyd","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0079-6123(02)39014-9","article-title":"Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis","volume":"139","author":"Neumann","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0185","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0190","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.npep.2010.06.001","article-title":"Short- and long-term consequences of different early environmental conditions on central immunoreactive oxytocin and arginine vasopressin levels in male rats","volume":"44","author":"Oreland","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0195","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0200","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1523\/JNEUROSCI.4829-08.2009","article-title":"A new role for FGF2 as an endogenous inhibitor of anxiety","volume":"13","author":"Perez","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0205","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0954579401003029","article-title":"Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models","volume":"13","author":"Sanchez","year":"2001","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0235","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1073\/pnas.1103732108","article-title":"Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals","volume":"108","author":"Turner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0240","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biopsych.2012.05.025","article-title":"Fibroblast growth factor-2: an endogenous antidepressant and anxiolytic molecule?","volume":"72","author":"Turner","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0245","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuron.2012.08.037","article-title":"The fibroblast growth factor family: neuromodulation of affective behavior","volume":"76","author":"Turner","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0250","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s002130050867","article-title":"Oxytocin as a possible mediator of SSRI-induced antidepressant effects","volume":"142","author":"Uvnas-Moberg","year":"1999","journal-title":"Psychopharmacology"},{"issue":"14","key":"10.1016\/j.yhbeh.2016.09.009_bb0255","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1523\/JNEUROSCI.19-14-06006.1999","article-title":"Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor","volume":"19","author":"Wagner","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0260","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nn.3420","article-title":"Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles","volume":"16","author":"Wang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0265","first-page":"409","article-title":"Oxytocin and complex social behavior: species comparisons","volume":"29","author":"Winslow","year":"1993","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.yhbeh.2016.09.009_bb0275","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yfrne.2014.01.001","article-title":"Corticotropin releasing factor: a key role in the neurobiology of addiction","volume":"35","author":"Zorrilla","year":"2014","journal-title":"Front. Neuroendocrinol."}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X16300952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X16300952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T18:02:26Z","timestamp":1718820146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X16300952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"alternative-id":["S0018506X16300952"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2016.09.009","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups","name":"articletitle","label":"Article Title"},{"value":"Hormones and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yhbeh.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}