{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:11:28Z","timestamp":1778692288389,"version":"3.51.4"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.yhbeh.2019.104651","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T13:06:03Z","timestamp":1575637563000},"page":"104651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Selective activation of estrogen receptors \u03b1 and \u03b2: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress"],"prefix":"10.1016","volume":"119","author":[{"given":"Rand S.","family":"Eid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie E.","family":"Lieblich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Duarte-Guterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Chaiton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda G.","family":"Mah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa A.M.","family":"Galea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2019.104651_bb0005","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.23-06-02333.2003","article-title":"Estrogen stimulates postsynaptic Density-95 rapid protein synthesis via the Akt\/protein kinase B pathway","author":"Akama","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-018-0262-4","article-title":"Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus","author":"Anacker","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0015","article-title":"Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression","author":"Bagot","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0020","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1210\/en.2004-0619","article-title":"Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor \u03b2","volume":"145","author":"Baker","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb5000","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2007.10.071","article-title":"Repeated estradiol administration alters different aspects of neurogenesis and cell death in the hippocampus of female, but not male, rats","author":"Barker","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2826.2008.01809.x","article-title":"Different forms of oestrogen rapidly upregulate cell proliferation in the dentate gyrus of adult female rats","volume":"21","author":"Barha","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0030","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.neurobiolaging.2015.04.007","article-title":"Multiparity-induced enhancement of hippocampal neurogenesis and spatial memory depends on ovarian hormone status in middle age","volume":"36","author":"Barha","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/S0928-8244(03)00202-5","article-title":"Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone","author":"Beagley","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0040","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-005-0179-0","article-title":"Animal model of menopausal depressive-like state in female mice: prolongation of immobility time in the forced swimming test following ovariectomy","author":"Bekku","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00136","article-title":"The HPA - immune axis and the immunomodulatory actions of glucocorticoids in the brain","author":"Bellavance","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01332","article-title":"Glucocorticoids, sex hormones, and immunity","author":"Bereshchenko","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2009.141","article-title":"The CRF system, stress, depression and anxietyinsights from human genetic studies","author":"Binder","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0060","series-title":"Mechanisms of Estrogen Receptor","author":"Bj\u00f6rnstr\u00f6m","year":"2005"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-00652-4","article-title":"Differential activation of endocrine-immune networks by arthritis challenge: insights from colony-specific responses","volume":"7","author":"Bodnar","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1214249110","article-title":"Mouse alarm pheromone shares structural similarity with predator scents","author":"Brechbuhl","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2008.07.003","article-title":"The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications","author":"Brinton","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2008.12.006","article-title":"Estrogen-induced plasticity from cells to circuits: predictions for cognitive function","author":"Brinton","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0085","doi-asserted-by":"crossref","DOI":"10.1210\/en.2010-0371","article-title":"Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors \u03b1 and \u03b2","author":"Brown","year":"2010","journal-title":"Endocrinology."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0090","doi-asserted-by":"crossref","DOI":"10.3791\/3769","article-title":"The tail suspension test","author":"Can","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0095","doi-asserted-by":"crossref","DOI":"10.3791\/3638-v","article-title":"The mouse forced swim test","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"2","key":"10.1016\/j.yhbeh.2019.104651_bb0100","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/joe.0.1440311","article-title":"The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat","volume":"144","author":"Carey","year":"1995","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2014.09.004","article-title":"Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration","author":"Chakrabarti","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yhbeh.2019.104651_bb6000","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12159","article-title":"Effects of chronic oestradiol, progesterone and medroxyprogesterone acetate on hippocampal neurogenesis and adrenal mass in adult female rats","author":"Chan","year":"2014","journal-title":"J. Neuroendocrinol"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/nm809","article-title":"In vivo imaging of transcriptionally active estrogen receptors","author":"Ciana","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/sj.npp.1301625","article-title":"Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice","author":"Clipperton","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0120","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/archpsyc.63.4.385","article-title":"Risk for new onset of depression during the menopausal transition the Harvard study of moods and cycles","volume":"63","author":"Cohen","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0125","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1177\/0192623315570339","article-title":"Vaginal cytology of the laboratory rat and mouse:review and criteria for the staging of the estrous cycle using stained vaginal smears","volume":"43","author":"Cora","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0130","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0135","doi-asserted-by":"crossref","DOI":"10.1017\/S1461145712000016","article-title":"Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects","author":"Duric","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2019.01.021","article-title":"Early and late effects of maternal experience on hippocampal neurogenesis, microglia, and the circulating cytokine milieu","volume":"78","author":"Eid","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.01.006","article-title":"Sex differences in depression: insights from clinical and preclinical studies","author":"Eid","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0150","doi-asserted-by":"crossref","unstructured":"Elenkov, I.J., Webster, E.L., Torpy, D.J., Chrousos, G.P., 1999. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune\/inflammatory response: acute and chronic effects, in: annals of the New York Academy of Sciences. New York Academy of Sciences, pp. 1\u201313. doi:https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb07618.x.","DOI":"10.1111\/j.1749-6632.1999.tb07618.x"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue","author":"Enache","year":"2019","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral Hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0165","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pnpbp.2008.10.005","article-title":"Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression","volume":"33","author":"Feyissa","year":"2009","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0170","article-title":"Estrogen potentiates adrenocortical responses to stress in female rats","author":"Figueiredo","year":"2007","journal-title":"Am. J. Physiol. Metab."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/S0091-3057(00)00392-0","article-title":"Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3\u03b1,5\u03b1-THP","author":"Frye","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2018.06.030","article-title":"Premarin has opposing effects on spatial learning, neural activation, and serum cytokine levels in middle-aged female rats depending on reproductive history","author":"Galea","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0185","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/j.2040-4603.2014.tb00575.x","article-title":"Sex differences in the HPA axis","volume":"4","author":"Goel","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12652","article-title":"Differential effects of chronic 17\u03b2-oestradiol treatment on rat behaviours relevant to depression","author":"Gogos","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0195","doi-asserted-by":"crossref","DOI":"10.1176\/appi.ajp.162.6.1192","article-title":"Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors","author":"Griffin","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/science.3871252","article-title":"Interactions between the gonadal steroids and the immune system","author":"Grossman","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0205","doi-asserted-by":"crossref","DOI":"10.32607\/20758251-2015-7-2-42-47","article-title":"NeuN as a neuronal nuclear antigen and neuron differentiation marker","author":"Gusel\u2019nikova","year":"2015","journal-title":"Acta Naturae"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2006.02.019","article-title":"Effects of estrogen and progesterone on spatial memory consolidation in aged females","author":"Harburger","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0220","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0033-3182(98)71355-6","article-title":"Hormonal changes in the postpartum and implications for postpartum depression","volume":"39","author":"Hendrick","year":"1998","journal-title":"Psychosomatics"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/nn.4113","article-title":"Neuroimmune mechanisms of depression","author":"Hodes","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2014.10.002","article-title":"Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway","author":"Ishihara","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0235","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biopsych.2006.07.039","article-title":"Combined dexamethasone\/corticotropin releasing hormone test predicts treatment response in major depression-a potential biomarker?","volume":"62","author":"Ising","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0240","article-title":"Principal component analysis","author":"Jolliffe","year":"2002","journal-title":"Second Edition. Encycl. Stat. Behav. Sci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0245","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2588-13.2013","article-title":"Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses","author":"Kallarackal","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/nm.2886","article-title":"Decreased expression of synapse-related genes and loss of synapses in major depressive disorder","author":"Kang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0255","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00213-011-2599-3","article-title":"Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice","author":"Kastenberger","year":"2012","journal-title":"similar to oestradiol. Psychopharmacol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2018.04.004","article-title":"Human adult neurogenesis: evidence and remaining questions","volume":"23","author":"Kempermann","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The epidemiology of depression across cultures","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2016.03.019","article-title":"Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction","author":"Kim","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0275","doi-asserted-by":"crossref","unstructured":"Kim, E., Sheng, M., 2004. PDZ DOMAIN PROTEINS OF SYNAPSES. Nat. Rev. | Neurosci. 5, 1. doi:https:\/\/doi.org\/10.1038\/nrn1517.","DOI":"10.1038\/nrn1517"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0280","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11055-016-0231-z","article-title":"Brain microglia and microglial markers","volume":"46","author":"Korzhevskii","year":"2016","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogen receptors regulate innate immune cells and signaling pathways","author":"Kovats","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0290","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","article-title":"Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis","volume":"19","author":"Kreisel","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression","author":"Kubera","year":"2011","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry."},{"issue":"1","key":"10.1016\/j.yhbeh.2019.104651_bb0300","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1139\/jpn.0205","article-title":"Low-dose dexamethasone challenge in women with atypical major depression: pilot study","volume":"27","author":"Levitan","year":"2002","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2008.01.006","article-title":"Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats","author":"Lewis","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0310","article-title":"Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice","author":"Li","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0315","article-title":"Ovariectomy results in variable changes in nociception, mood and depression in adult female rats","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0320","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.20354","article-title":"Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization","author":"Lind","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0325","series-title":"Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-\u03b1) and Soluble Interleukin-2 Receptors (sIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-analysis and Meta-regression","author":"Liu","year":"2012"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03567-4","article-title":"Estrogen receptor \u03b1 drives pro-resilient transcription in mouse models of depression","author":"Lorsch","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2016.01.033","article-title":"Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats","volume":"107","author":"Mahmoud","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0340","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuropharm.2016.01.033","article-title":"Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats","volume":"107","author":"Mahmoud","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0345","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yfrne.2016.03.002","article-title":"Sex hormones and adult hippocampal neurogenesis: regulation, implications, and potential mechanisms","volume":"41","author":"Mahmoud","year":"2016","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0350","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.comppsych.2007.06.012","article-title":"Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the sequenced treatment alternatives to relieve depression study","volume":"49","author":"Marcus","year":"2008","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0355","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.neuroscience.2006.05.032","article-title":"Both estrogen receptor \u03b1 and estrogen receptor \u03b2 agonists enhance cell proliferation in the dentate gyrus of adult female rats","volume":"141","author":"Mazzucco","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0360","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yhbeh.2012.09.011","article-title":"17-\u03b2 estradiol, but not estrone, increases the survival and activation of new neurons in the hippocampus in response to spatial memory in adult female rats","volume":"63","author":"McClure","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0365","doi-asserted-by":"crossref","DOI":"10.1177\/1745691613506907","article-title":"The brain on stress: toward an integrative approach to brain, body, and behavior","author":"McEwen","year":"2013","journal-title":"Perspect. Psychol. Sci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2015.171","article-title":"Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex","author":"McEwen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0375","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1021\/jm010254a","article-title":"Estrogen receptor-\u03b2 potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues","volume":"44","author":"Meyers","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0380","doi-asserted-by":"crossref","DOI":"10.1111\/j.1601-183X.2006.00249.x","article-title":"Estrous cycle effects on behavior of C57BL\/6J and BALB\/cByJ female mice: implications for phenotyping strategies","author":"Meziane","year":"2007","journal-title":"Genes, Brain Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0385","doi-asserted-by":"crossref","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0390","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2015.00006","article-title":"An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL\/6 mice","author":"Monteiro","year":"2015","journal-title":"Front. Psychiatry."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0395","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","author":"Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0400","doi-asserted-by":"crossref","DOI":"10.1006\/hbeh.2001.1716","article-title":"Effects of estrogen on activity and fear-related behaviors in mice","author":"Morgan","year":"2001","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/S0166-4328(01)00398-9","article-title":"Estrogen\u2019s effects on activity, anxiety, and fear in two mouse strains","author":"Morgan","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0410","article-title":"Gonadal steroids and immunity","author":"Olsen","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/S0306-4522(00)00474-7","article-title":"Reproductive status influences cell proliferation and cell survival in the dentate gyrus of adult female meadow voles: a possible regulatory role for estradiol","author":"Ormerod","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0420","doi-asserted-by":"crossref","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic\u2013pituitary\u2013adrenal and hypothalamic\u2013pituitary\u2013gonadal axes: sex differences in regulation of stress responsivity","author":"Oyola","year":"2017","journal-title":"Stress."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00244","article-title":"Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats","author":"Pacheco","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2016.01.011","article-title":"Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior","author":"Padilla-Coreano","year":"2016","journal-title":"Neuron."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0435","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.6076-11.2012","article-title":"Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory","author":"Pan","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2004.04.008","article-title":"Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress","author":"Pothion","year":"2004","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.yhbeh.2019.104651_bb0445","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nbt0308-303","article-title":"What is principle component analysis?","volume":"26","author":"Ringner","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0450","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-004-2078-1","article-title":"17\u03b2-Estradiol-induced antidepressant-like effect in the Forced Swim Test is absent in estrogen receptor-\u03b2 knockout (BERKO) mice","author":"Rocha","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0455","doi-asserted-by":"crossref","DOI":"10.3109\/00048678609158899","article-title":"Pre-menopausal and post-menopausal depressed women","author":"Roy","year":"1986","journal-title":"Australas. Psychiatry."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2011.03.050","article-title":"An ADIOL-ER\u03b2-CtBP transrepression pathway negatively regulates microglia-mediated inflammation","author":"Saijo","year":"2011","journal-title":"Cell."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0465","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1037\/bul0000102","article-title":"Gender differences in depression in representative national samples: meta-analyses of diagnoses and symptoms","volume":"143","author":"Salk","year":"2017","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0470","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-61779-313-4_7","article-title":"Novelty-suppressed feeding in the mouse","author":"Samuels","year":"2011","journal-title":"Neuromethods."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0475","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2011.01.008","article-title":"Stress, stress hormones, and adult neurogenesis","author":"Schoenfeld","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0485","doi-asserted-by":"crossref","DOI":"10.1677\/JOE-10-0029","article-title":"Modulation of responses to stress by estradiol benzoate and selective estrogen receptor agonists","author":"Serova","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0490","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0495","first-page":"339","author":"Setiawan","year":"2018","journal-title":"Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0500","article-title":"Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death","author":"Smith","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0505","doi-asserted-by":"crossref","DOI":"10.1097\/GME.0000000000000193","article-title":"Mood disorders in midlife women: understanding the critical window and its clinical implications","author":"Soares","year":"2014","journal-title":"Menopause."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0510","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2011.00077","article-title":"Rapid estradiol modulation of neuronal connectivity and its implications for disease","author":"Srivastava","year":"2011","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0515","doi-asserted-by":"crossref","unstructured":"Stauffer, S.R., Coletta, C.J., Tedesco, R., Nishiguchi, G., Carlson, K., Sun, J., Katzenellenbogen, B.S., Katzenellenbogen, J. a, 2000. Pyrazole ligands: structure-affinity\/activity relationships and estrogen receptor-alpha-selective agonists. J. Med. Chem. 43, 4934\u20134947. doi:jm000170m [pii].","DOI":"10.1021\/jm000170m"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2011.02.001","article-title":"Novelty-seeking behavior predicts vulnerability in a rodent model of depression","author":"Stedenfeld","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0525","doi-asserted-by":"crossref","DOI":"10.1097\/PSY.0b013e31820ad12b","article-title":"Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0530","doi-asserted-by":"crossref","DOI":"10.1038\/nrn3785","article-title":"Functional organization of the hippocampal longitudinal axis","author":"Strange","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0535","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/mp.2011.48","article-title":"Antidepressants recruit new neurons to improve stress response regulation","volume":"16","author":"Surget","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0540","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1523\/JNEUROSCI.19-14-05792.1999","article-title":"Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat","volume":"19","author":"Tanapat","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0545","doi-asserted-by":"crossref","DOI":"10.1002\/cne.20385","article-title":"Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner","author":"Tanapat","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2019.05.003","article-title":"Human hippocampal neurogenesis persists in aged adults and Alzheimer\u2019s disease patients","author":"Tobin","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0555","doi-asserted-by":"crossref","unstructured":"Vegeto, E., Bonincontro, C., Pollio, G., Sala, a, Viappiani, S., Nardi, F., Brusadelli, a, Viviani, B., Ciana, P., Maggi, a, 2001. Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. J. Neurosci. 21, 1809\u20131818. doi:21\/6\/1809 [pii].","DOI":"10.1523\/JNEUROSCI.21-06-01809.2001"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2008.04.001","article-title":"Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases","author":"Vegeto","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0565","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/npp.2015.337","article-title":"Enzymatic depletion of the polysialic acid moiety associated with the neural cell adhesion molecule inhibits antidepressant efficacy","volume":"41","author":"Wainwright","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0570","doi-asserted-by":"crossref","DOI":"10.1038\/sj.npp.1300713","article-title":"ER\u03b2-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats","author":"Walf","year":"2005","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2009.09.017","article-title":"Estradiol reduces anxiety- and depression-like behavior of aged female mice","author":"Walf","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0580","series-title":"Pharmacology Biochemistry and Behavior","article-title":"Antidepressant effects of ER\u03b2-selective estrogen receptor modulators in the forced swim test","author":"Walf","year":"2004"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0585","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.nlm.2008.01.008","article-title":"Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks","volume":"89","author":"Walf","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0590","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbr.2008.09.016","article-title":"Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze","volume":"196","author":"Walf","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2009.01.004","article-title":"Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance","author":"Walf","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0600","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbx035","article-title":"Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder, and depression","author":"Wang","year":"2018","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2009.06.090","article-title":"Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus","author":"Waters","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2008.12.058","article-title":"Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus","author":"Weiser","year":"2009","journal-title":"Neuroscience."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0615","doi-asserted-by":"crossref","DOI":"10.1210\/en.2008-1355","article-title":"Estrogen receptor-\u03b2 agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress","author":"Weiser","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2010.03.098","article-title":"Estrogen receptor beta activation prevents glucocorticoid receptor-dependent effects of the central nucleus of the amygdala on behavior and neuroendocrine function","author":"Weiser","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0625","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1523\/JNEUROSCI.0885-17.2017","article-title":"Effects of chronic social defeat stress on sleep and circadian rhythms are mitigated by kappa-opioid receptor antagonism","volume":"37","author":"Wells","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0630","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage","author":"Willner","year":"2017","journal-title":"Neurobiol. Stress."},{"issue":"12","key":"10.1016\/j.yhbeh.2019.104651_bb0635","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1523\/JNEUROSCI.10-12-04035.1990","article-title":"Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons","volume":"10","author":"Woolley","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104651_bb0640","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hipo.22375","article-title":"Prior high corticosterone exposure reduces activation of immature neurons in the ventral hippocampus in response to spatial and nonspatial memory","volume":"25","author":"Workman","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0645","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/WNR.0000000000000052","article-title":"Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone","volume":"25","author":"Yang","year":"2014","journal-title":"Neuroreport"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0650","article-title":"Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder","author":"Yehuda","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104651_bb0655","doi-asserted-by":"crossref","DOI":"10.1001\/archpsyc.1993.01820170073010","article-title":"Dissociation between pituitary and adrenal suppression to dexamethasone in depression","author":"Young","year":"1993","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:37:21Z","timestamp":1758069441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X19304581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":133,"alternative-id":["S0018506X19304581"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104651","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/758862","asserted-by":"object"}]},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective activation of estrogen receptors \u03b1 and \u03b2: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress","name":"articletitle","label":"Article Title"},{"value":"Hormones and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104651"}}