{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:15:40Z","timestamp":1772579740849,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["411\/18"],"award-info":[{"award-number":["411\/18"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/09799-1"],"award-info":[{"award-number":["2013\/09799-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008992","name":"International Society for Neurochemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["D.2555\/16"],"award-info":[{"award-number":["D.2555\/16"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006449","name":"Fundaci\u00f3n Alberto J. Roemmers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016 N 0869- PICT 2017 N 1658"],"award-info":[{"award-number":["PICT 2016 N 0869- PICT 2017 N 1658"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.yhbeh.2019.104658","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T01:26:56Z","timestamp":1578360416000},"page":"104658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Brain osmo-sodium sensitive channels and the onset of sodium appetite"],"prefix":"10.1016","volume":"118","author":[{"given":"C.Y.","family":"Porcari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.K.","family":"Debarba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Amigone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.E.","family":"Caeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.C.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Mecawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.L.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Antunes-Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Godino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2019.104658_bb0005","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13259","article-title":"Osmotic activation of a Ca2+ dependent phospholipase C pathway that regulates \u2206N TRPV1-mediated currents in rat supraoptic neurons","volume":"5","author":"Bansal","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/expphysiol.2006.035634","article-title":"Neurophysiological characterization of mammalian osmosensitive neurones","volume":"92","author":"Bourque","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0020","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0025","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/exnr.2001.7780","article-title":"Peptidergic excitation of supraoptic nucleus neurons: involvement of stretch-inactivated cation channels","volume":"171","author":"Chakfe","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0030","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1096\/fj.01-0531fje","article-title":"Acute sodium deficit triggers plasticity of the brain angiotensin type 1 receptors","volume":"16","author":"Charron","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0035","doi-asserted-by":"crossref","first-page":"9069","DOI":"10.1523\/JNEUROSCI.0877-06.2006","article-title":"Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality","volume":"26","author":"Ciura","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0040","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.celrep.2018.04.090","article-title":"Trpv4 mediates hypotonic inhibition of central osmosensory neurons via taurine gliotransmission","volume":"23","author":"Ciura","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/ajpregu.00447.2013","article-title":"Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion","volume":"306","author":"Dadam","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0031-9384(77)90327-4","article-title":"Changes in volemia and natremia and onset of sodium appetite in sodium depleted rats","volume":"19","author":"Ferreyra","year":"1977","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0055","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.1998.78.3.583","article-title":"Angiotensin, thirst, and sodium appetite","volume":"78","author":"Fitzsimons","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0060","first-page":"1180","article-title":"Distribution of Fosimmunoreactivity in rat brain after sodium consumption induced by peritoneal dialysis","volume":"276","author":"Franchini","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1113\/expphysiol.2007.039891","article-title":"Central regulation of sodium appetite","volume":"93","author":"Geerling","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuroscience.2005.02.035","article-title":"Neurochemical caracterization of the neuronal groups activated after isotonic blood volume expansion","volume":"133","author":"Godino","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0075","first-page":"2387","article-title":"Management of hyponatremia","volume":"69","author":"Goh","year":"2004","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2016.07.007","article-title":"Sodium sensing in the subfornical organ and body-fluid homeostasis","volume":"113","author":"Hiyama","year":"2016","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0085","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0079-6123(02)39010-1","article-title":"Glial cells in the hypothalamo- neurohypophysial system: key elements of the regulation of neuronal electrical and secretory activity","volume":"139","author":"Hussy","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0090","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1096\/fasebj.7.8.8500693","article-title":"Sensory circumventricular organs and brain homeostatic pathways","volume":"7","author":"Johnson","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0095","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1152\/ajpregu.00102.2014","article-title":"Osmoregulatory thirst in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) and\/or type 4 (TRPV4) receptor","volume":"307","author":"Kinsman","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0100","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0105","doi-asserted-by":"crossref","first-page":"13698","DOI":"10.1073\/pnas.1735416100","article-title":"Abnormal osmotic regulation in trpv4\u2212\/\u2212 mice","volume":"100","author":"Liedtke","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0110","first-page":"525","article-title":"Vanilloid receptor-related osmotically activated channel (VR-OAC)","volume":"103","author":"Liedtke","year":"2000","journal-title":"a candidate vertebrate osmoreceptor. Cell."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0115","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuroscience.2015.03.059","article-title":"Temporal dissociation between sodium depletion and sodium appetite appearance: involvement of inhibitory and stimulatory signals","volume":"297","author":"Margatho","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0120","doi-asserted-by":"crossref","unstructured":"Matsuda, T., Hiyama, T.Y., Niimura, F., Matsusaka, T., Fukamizu, A., Kobayashi, K., Kobayashi, K., Noda, M. 2017 Distinct neural mechanisms for the control of thirst and salt appetite in the subfornicalorgan.NatNeurosci. 20, 230\u2013241. doi:https:\/\/doi.org\/10.1038\/nn.4463.","DOI":"10.1038\/nn.4463"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0125","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/ajpregu.00481.2012","article-title":"Adaptive appetites for salted and unsalted food in rats: differential effects of sodium depletion, DOCA","volume":"304","author":"McKinley","year":"2013","journal-title":"and dehydration. Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/364341a0","article-title":"Mechanosensitive channels transduce osmosensitivity in supraoptic neurons","volume":"364","author":"Oliet","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0140","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/mol.116.104158","article-title":"Channels and volume changes in the life and death of the cell","volume":"90","author":"Pasantes-Morales","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0361-9230(97)00112-3","article-title":"Effect of intravenous captopril on c-fos expression induced by sodium depletion in neurons of the lamina terminalis","volume":"44","author":"Pastuskovas","year":"1997","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0150","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0160","doi-asserted-by":"crossref","unstructured":"Porcari, C.Y., Araujo, I.G., Urzedo-Rodrigues, L., De Luca, L.A. Jr., Menani, J.V., Caeiro, X.E., Imboden, H., Antunes-Rodrigues, J., Reis, L.C., Vivas, L., Godino, A., Mecawi, A.S., 2019. Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus. J. Neuroendocrinol. 31, e12703. doi:https:\/\/doi.org\/10.1111\/jne.12703.","DOI":"10.1111\/jne.12703"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0170","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nn1614","article-title":"An N-terminal variant of Trpv1 channel is required for osmosensory transduction","volume":"9","author":"Sharif Naeini","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0175","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2826.2003.00969.x","article-title":"Circulating angiotensin II activates neurones in circumventricular organs of the lamina terminalis that project to the bed nucleus of the stria terminalis","volume":"15","author":"Sunn","year":"2003","journal-title":"JNeuroendocrinol"},{"key":"10.1016\/j.yhbeh.2019.104658_bb0180","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1152\/ajpregu.00003.2008","article-title":"Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia","volume":"294","author":"Taylor","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0185","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/ajpregu.00483.2015","article-title":"Hypernatremia-induced vasopressin secretion is not altered in TRPV1\u2212\/\u2212 rats","volume":"311","author":"Tucker","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0190","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0006-8993(91)90806-7","article-title":"Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats","volume":"567","author":"Verbalis","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0006-8993(95)00208-8","article-title":"Sodium depletion induces Fos immunoreactivity in circumventricular organs of the lamina terminalis","volume":"679","author":"Vivas","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0205","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1152\/ajpregu.00618.2005","article-title":"Sodium-level-sensitive sodium channel Na(x) is expressed in glial laminate processes in the sensory circumventricular organs","volume":"290","author":"Watanabe","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yhbeh.2019.104658_bb0210","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1523\/JNEUROSCI.1495-08.2008","article-title":"Amplification of transducer gain by angiotensin II-mediated enhancement of cortical actin density in osmosensory neurons","volume":"28","author":"Zhang","year":"2008","journal-title":"J. Neurosci."}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:41:58Z","timestamp":1762173718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X19304659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":37,"alternative-id":["S0018506X19304659"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104658","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain osmo-sodium sensitive channels and the onset of sodium appetite","name":"articletitle","label":"Article Title"},{"value":"Hormones and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104658"}}