{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:29:10Z","timestamp":1793820550692,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001236","name":"Queen Elisabeth Medical Foundation","doi-asserted-by":"publisher","award":["G.S.K.E \u2013 2017-2019"],"award-info":[{"award-number":["G.S.K.E \u2013 2017-2019"]}],"id":[{"id":"10.13039\/100001236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fund for Scientific Research Flanders","doi-asserted-by":"publisher","award":["G.0287.16"],"award-info":[{"award-number":["G.0287.16"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","award":["SRP49"],"award-info":[{"award-number":["SRP49"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.yhbeh.2019.104666","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T11:43:47Z","timestamp":1583149427000},"page":"104666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL\/6J mice"],"prefix":"10.1016","volume":"121","author":[{"given":"An","family":"De Prins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissal","family":"Allaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Eeckhaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ballet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Smolders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"De Bundel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yhbeh.2019.104666_bb0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","article-title":"Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid","volume":"572","author":"Ahn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pnpbp.2015.01.010","article-title":"Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision","volume":"59","author":"Bentea","year":"2015","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1124\/pr.56.2.3","article-title":"Neuromedin U and its receptors: structure, function, and physiological roles","volume":"56","author":"Brighton","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0020","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ejmech.2017.12.035","article-title":"Development of potent and proteolytically stable human neuromedin U receptor agonists","volume":"144","author":"De Prins","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/acsmedchemlett.8b00105","article-title":"Synthesis and in vitro evaluation of stabilized and selective neuromedin U-1 receptor agonists","volume":"9","author":"De Prins","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0035","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1523\/JNEUROSCI.13-09-03932.1993","article-title":"Topographic patterns of brain activity in response to swim stress: assessment by 2-deoxyglucose uptake and expression of Fos-like immunoreactivity","volume":"13","author":"Duncan","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-004-1918-3","article-title":"Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats","volume":"177","author":"Gartlon","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0045","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1046\/j.1471-4159.2003.02079.x","article-title":"Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status","volume":"87","author":"Graham","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/bbrc.2001.5945","article-title":"A role for neuromedin U in stress response","volume":"289","author":"Hanada","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nm1106","article-title":"Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway","volume":"10","author":"Hanada","year":"2004","journal-title":"Nat. Med."},{"issue":"81\u2013109","key":"10.1016\/j.yhbeh.2019.104666_bb0060","first-page":"C101","article-title":"Stress hormone regulation: biological role and translation into therapy","volume":"61","author":"Holsboer","year":"2010","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0065","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/35017610","article-title":"Identification of receptors for neuromedin U and its role in feeding","volume":"406","author":"Howard","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0070","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1210\/en.2002-220121","article-title":"Evaluation of neuromedin U actions in energy homeostasis and pituitary function","volume":"143","author":"Ivanov","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0075","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0350-16.2017","article-title":"The arcuate nucleus: a site of fast negative feedback for corticosterone secretion in male rats","volume":"4","author":"Leon-Mercado","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2012.00024","article-title":"Synaptic regulation of the hypothalamic\u2013pituitary\u2013adrenal axis and its modulation by glucocorticoids and stress","volume":"6","author":"Levy","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0085","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002130100694","article-title":"Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice","volume":"155","author":"Lucki","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0090","first-page":"419","article-title":"Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis","volume":"7","author":"Malendowicz","year":"1993","journal-title":"In Vivo"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0143-4179(94)90092-2","article-title":"Effects of neuromedin U (NMU)-8 on the rat hypothalamo-pituitary-adrenal axis. Evidence of a direct effect of NMU-8 on the adrenal gland","volume":"26","author":"Malendowicz","year":"1994","journal-title":"Neuropeptides"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1373\/clinchem.2014.231753","article-title":"Neuromedin U: a multifunctional neuropeptide with pleiotropic roles","volume":"61","author":"Martinez","year":"2015","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0105","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol. Rev."},{"issue":"Suppl. 3","key":"10.1016\/j.yhbeh.2019.104666_bb0110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0196-9781(85)90381-X","article-title":"Neuromedins: novel smooth-muscle stimulating peptides identified in porcine spinal cord","volume":"6","author":"Minamino","year":"1985","journal-title":"Peptides"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1476-5381.2009.00252.x","article-title":"Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S","volume":"158","author":"Mitchell","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/bph.14077","article-title":"Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice","volume":"175","author":"Nagai","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0125","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbrc.2004.08.136","article-title":"Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice","volume":"323","author":"Nakahara","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/ENDO:16:3:201","article-title":"Central administration of neuromedin U activates neurons in ventrobasal hypothalamus and brainstem","volume":"16","author":"Niimi","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0135","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2826.2006.01454.x","article-title":"Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis","volume":"18","author":"Novak","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0140","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1210\/en.2002-220201","article-title":"Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat","volume":"143","author":"Ozaki","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1196\/annals.1410.062","article-title":"Stress-induced activation of neurons in the ventromedial arcuate nucleus: a blood-brain-CSF interface of the hypothalamus","volume":"1148","author":"Palkovits","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0150","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0155","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1210\/en.2008-1772","article-title":"The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)","volume":"150","author":"Peier","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0160","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1210\/en.2010-1463","article-title":"Effects of peripherally administered neuromedin U on energy and glucose homeostasis","volume":"152","author":"Peier","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0165","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0170","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.pnpbp.2007.04.010","article-title":"Reduced evoked fos expression in activity-related brain regions in animal models of behavioral depression","volume":"31","author":"Stone","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0175","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbr.2013.11.005","article-title":"Neurotransmissions of antidepressant-like effects of neuromedin U-23 in mice","volume":"259","author":"Tanaka","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbrc.2004.08.058","article-title":"Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight","volume":"323","author":"Thompson","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0185","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/adb.12355","article-title":"Central administration of the anorexigenic peptide neuromedin U decreases alcohol intake and attenuates alcohol-induced reward in rodents","volume":"22","author":"Vallof","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0190","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1210\/en.2002-220308","article-title":"Hypothalamic actions of neuromedin U","volume":"143","author":"Wren","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/10253890410001727370","article-title":"Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U","volume":"7","author":"Yokota","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.yhbeh.2019.104666_bb0200","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1128\/MCB.01148-06","article-title":"Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding","volume":"26","author":"Zeng","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yhbeh.2019.104666_bb0205","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/mp.2016.136","article-title":"Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice","volume":"22","author":"Zhang","year":"2017","journal-title":"Mol. Psychiatry"}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X19304738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:39:55Z","timestamp":1758069595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X19304738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":41,"alternative-id":["S0018506X19304738"],"URL":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104666","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL\/6J mice","name":"articletitle","label":"Article Title"},{"value":"Hormones and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yhbeh.2019.104666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104666"}}