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Chem."},{"key":"10.1016\/j.yhbeh.2026.106003_bb0880","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2014.09.019","article-title":"Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus","volume":"1588","author":"Mukuda","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.yhbeh.2026.106003_bb0885","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ebiom.2015.09.006","article-title":"A Lifetime Prevalence of Comorbidity Between Bipolar Affective Disorder and Anxiety Disorders: A Meta-analysis of 52 Interview-based Studies of Psychiatric Population","volume":"2","author":"Nabavi","year":"2015","journal-title":"eBioMedicine"},{"key":"10.1016\/j.yhbeh.2026.106003_bb0890","article-title":"Neurovascular unit dysfunction and blood\u2013brain barrier hyperpermeability contribute to schizophrenia neurobiology: a theoretical integration of clinical and experimental evidence","volume":"8","author":"Najjar","year":"2017","journal-title":"Front. 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