{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:35:21Z","timestamp":1791192921822,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015639","name":"Japan Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.yjmcc.2004.10.012","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T08:06:54Z","timestamp":1103184414000},"page":"163-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation"],"prefix":"10.1016","volume":"38","author":[{"given":"Yasuhiro","family":"Maejima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kino","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2004.10.012_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(01)00495-0","article-title":"Nitrosylation: the prototypic redox-based signaling mechanism","volume":"106","author":"Stamler","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib2","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.274.11.6823","article-title":"Nitric oxide inhibits caspase-3 by S-nitrosylation in vivo","volume":"274","author":"R\u00f6ssig","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1083\/jcb.200104008","article-title":"S-nitrosylation of mitochondrial caspases","volume":"154","author":"Mannick","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0014-4827(03)00156-3","article-title":"Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP-dependent mechanism and independently of caspase 3 nitrosylation","volume":"287","author":"Dash","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","article-title":"Human ICE\/CED-3 protease nomenclature","volume":"87","author":"Alnemri","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib6","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib7","first-page":"3976","article-title":"Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis","volume":"53","author":"Kaufmann","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1006\/jmcc.2002.2091","article-title":"ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3","volume":"34","author":"Nobori","year":"2002","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib9","first-page":"H2036","article-title":"Essential roles for G1 cyclin-dependent kinase activity in development of cardiomyocyte hypertrophy","volume":"275","author":"Tamamori","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/01.RES.88.4.408","article-title":"Cyclin A\/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes","volume":"88","author":"Adachi","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.8108732","article-title":"Premature p34cdc2 activation required for apoptosis","volume":"263","author":"Shi","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/01.RES.84.3.257","article-title":"Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane","volume":"84","author":"Sawyer","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib13","first-page":"1039","article-title":"Phenotypes of c-Myc deficient rat fibroblasts isolated by targeted homologous recombination","volume":"8","author":"Mateyak","year":"1997","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0026-895X(25)10233-2","article-title":"Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H- [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one","volume":"48","author":"Garthwaite","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/excr.1998.4310","article-title":"Nitric oxide induces apoptotic death of cardiomyocytes via a cyclic-GMP-dependent pathway","volume":"247","author":"Shimojo","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib16","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1074\/jbc.M209264200","article-title":"Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species","volume":"278","author":"Setsukinai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35055104","article-title":"Protein S-nitrosylation: a physiological signal for neuronal nitric oxide","volume":"3","author":"Jaffrey","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0076-6879(99)01083-6","article-title":"Detection of S-nitrosothiols by fluorometric and colorimetric methods","volume":"301","author":"Wink","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib19","first-page":"1648","article-title":"Nitric oxide inhibits apoptosis downstream of cytochrome c release by nitrosylating caspase 9","volume":"62","author":"T\u00f6r\u00f6k","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib20","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1074\/jbc.C100746200","article-title":"Basal and stimulated protein S-nitrosylation in multiple cell types and tissues","volume":"277","author":"Gow","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib21","first-page":"1745","article-title":"A general mechanism for microsomal activation of quinone anticancer agents to free radicals","volume":"38","author":"Bachur","year":"1978","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib22","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib23","doi-asserted-by":"crossref","first-page":"48093","DOI":"10.1074\/jbc.M108622200","article-title":"Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore","volume":"276","author":"Takuma","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1096\/fj.02-0738com","article-title":"Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase\/Akt activation","volume":"17","author":"Ha","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib25","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1006\/bbrc.2001.5477","article-title":"Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia\u2013reoxygenation injury","volume":"286","author":"Rakhit","year":"2001","journal-title":"Biochem Biophys Res. Commun"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1006\/bbrc.2000.2522","article-title":"Activation of Akt during simulated ischemia\/reperfusion in cardiac myocytes","volume":"270","author":"Mockridge","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib27","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1161\/01.CIR.103.21.2617","article-title":"Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes","volume":"103","author":"Rakhit","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib28","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0008-6363(03)00425-5","article-title":"Nitric oxide inhibits ischemia\/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity","volume":"59","author":"Maejima","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib29","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI119730","article-title":"Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy","volume":"100","author":"Li","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib30","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1172\/JCI10226","article-title":"Myocardial protection from ischemia\/reperfusion injury by endogenous and exogenous HGF","volume":"106","author":"Nakamura","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1172\/JCI18200","article-title":"A novel protective effect of erythropoietin in the infarcted heart","volume":"112","author":"Parsa","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI118871","article-title":"Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells","volume":"98","author":"Zeng","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0021-9150(02)00384-2","article-title":"Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth","volume":"167","author":"Maejima","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.yjmcc.2004.10.012_bib34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00005344-200310000-00011","article-title":"Erythropoietin administration in vivo increases vascular nitric oxide synthase expression","volume":"42","author":"Kanagy","year":"2003","journal-title":"J. Cardiovasc Pharmacol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib35","doi-asserted-by":"crossref","first-page":"H92","DOI":"10.1016\/S0002-9149(99)00269-6","article-title":"Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts","volume":"83","author":"Mital","year":"1999","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib36","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/S0735-1097(00)00948-7","article-title":"Left ventricular assist device preserves nitric oxide dependent control of mitochondrial respiration in failing human hearts","volume":"36","author":"Mital","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(03)00917-7","article-title":"Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction","volume":"551","author":"Hoffmann","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib38","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/ncb851","article-title":"Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69","volume":"4","author":"Haendeler","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib39","doi-asserted-by":"crossref","first-page":"18265","DOI":"10.1074\/jbc.M212459200","article-title":"Nitrosylation of cytochrome c during apoptosis","volume":"278","author":"Schonhoff","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib40","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/01.RES.85.9.829","article-title":"Cytokine-mediated apoptosis in cardiac myocytes\u2014the role of inducible nitric oxide synthase induction and peroxynitrite generation","volume":"85","author":"Arstall","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2004.10.012_bib41","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/sj.onc.1207559","article-title":"Regulation of the apoptosis-necrosis switch","volume":"23","author":"Nicotera","year":"2004","journal-title":"Oncogene"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282804003153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282804003153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:13:58Z","timestamp":1758312838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282804003153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0022282804003153"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2004.10.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2004.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}