{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:15:12Z","timestamp":1793222112304,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.yjmcc.2008.01.005","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T15:10:15Z","timestamp":1202829015000},"page":"647-653","source":"Crossref","is-referenced-by-count":100,"title":["The role of NHE-1 in myocardial hypertrophy and remodelling"],"prefix":"10.1016","volume":"44","author":[{"given":"Morris","family":"Karmazyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Kili\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabzali","family":"Javadov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2008.01.005_bib1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1161\/CIRCULATIONAHA.106.626929","article-title":"Sodium\u2013hydrogen exchanger, cardiac overload, and myocardial hypertrophy","volume":"115","author":"Cingolani","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/01.HYP.27.4.859","article-title":"Phorbol ester activation of the rat vascular myocyte Na+\/H+ exchanger isoform I","volume":"27","author":"Sisczkowski","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib3","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1021\/bi970802f","article-title":"Phosphorylation and regulation of the Na+\/H+ exchanger through mitogen-activated protein kinase","volume":"29","author":"Wang","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib4","doi-asserted-by":"crossref","first-page":"22985","DOI":"10.1074\/jbc.274.33.22985","article-title":"Protein kinase mediated regulation of the Na+\/H+ exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways","volume":"274","author":"Moor","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib5","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1074\/jbc.M100519200","article-title":"Activation of Na+\/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium","volume":"276","author":"Moor","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1124\/mol.106.029900","article-title":"Evidence for direct regulation of myocardial Na+\/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to \u03b11-adrenergic stimulation","volume":"71","author":"Cuello","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib7","doi-asserted-by":"crossref","first-page":"20252","DOI":"10.1074\/jbc.M600268200","article-title":"A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+\/H+ exchanger NHE1","volume":"281","author":"Snabaitis","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.RES.75.2.369","article-title":"Role of Na+\u2013H+ exchange in mediating the effects of endothelin-1 on the normal and ischemic and reperfused heart","volume":"75","author":"Khandoudi","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1113\/jphysiol.1993.sp019917","article-title":"The modulatory effects of endothelin-1, carbachol and isoprenaline upon Na+\u2013H+ exchange in dog cardiac Purkinje fibers","volume":"471","author":"Wu","year":"1993","journal-title":"J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1172\/JCI119123","article-title":"Endothelin and angiotensin II stimulation of Na+\u2013H+ exchange is impaired in cardiac hypertrophy","volume":"99","author":"Ito","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0008-6363(96)88573-7","article-title":"Angiotensin II stimulates sodium\u2013hydrogen exchange in adult rabbit ventricular myocytes","volume":"29","author":"Matsui","year":"1995","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0022-3565(24)37437-3","article-title":"Effects of angiotensin II on intracellular calcium and contracture in metabolically inhibited cardiomyocytes","volume":"285","author":"Boston","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib13","first-page":"H1131","article-title":"Dissociation between positive inotropic and alkalinizing effects of angiotensin II in feline myocardium","volume":"272","author":"Mattiazi","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib14","doi-asserted-by":"crossref","first-page":"C1096","DOI":"10.1152\/ajpcell.1992.263.5.C1096","article-title":"\u03b11-Adrenergic stimulation of the Na\u2013H exchange in cardiac myocytes","volume":"263","author":"Wallert","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0008-6363(96)88567-1","article-title":"Neurohumoral modulation of intracellular pH in the heart","volume":"29","author":"Puceat","year":"1995","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib16","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/01.RES.82.10.1078","article-title":"\u03b11-adrenergic stimulation of sarcolemmal Na+\u2013H+ exchanger activity in rat ventricular myocytes: evidence for selective mediation by the \u03b11A-adrenoceptor subtype","volume":"82","author":"Yokoyama","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib17","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.89.6.2424","article-title":"The Na+\/H+ antiporter cytoplasmic domain mediates growth factor signals and controls \u201cH+ sensing\u201d","volume":"89","author":"Wakabayashi","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib18","series-title":"Heart Failure. Pathophysiology, molecular biology, and clinical management","author":"Katz","year":"2000"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/01.RES.82.4.430","article-title":"Role of ion channels and exchanger in mechanical stretch-induced cardiomyocyte hypertrophy","volume":"82","author":"Yamazaki","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/01.RES.83.8.775","article-title":"Stretch-induced alkalinization of feline papillary muscle. An autocrine\u2013paracrine system","volume":"83","author":"Cingolani","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1253\/jcj.54.535","article-title":"The role of Na+\/H+ exchange in norepinephrine-induced protein synthesis in neonatal cultured cardiomyocytes","volume":"54","author":"Hori","year":"1990","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib22","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/01.RES.83.8.870","article-title":"Angiotensin and endothelin: messengers that couple ventricular stretch to the Na+\/H+ exchanger and cardiac hypertrophy","volume":"83","author":"Dostal","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0008-6363(99)00210-2","article-title":"Na+\/H+ exchange hyperactivity and myocardial hypertrophy: are they linked phenomena?","volume":"44","author":"Cingolani","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib24","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0008-6363(02)00809-X","article-title":"Increased Na+\/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model","volume":"57","author":"Baartscheer","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0735-1097(00)00730-0","article-title":"Sarcolemmal Na+\/H+ exchanger activity and expression in human ventricular myocardium","volume":"36","author":"Yokoyama","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1006\/jmcc.1998.0640","article-title":"Influence of pHi and creatine phosphate on \u03b1-adrenoceptor-mediated cardiac hypertrophy","volume":"30","author":"Schluter","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1161\/01.HYP.0000071180.12012.6E","article-title":"Regression of isoproterenol-induced cardiac hypertrophy by Na+\/H+ exchanger inhibition","volume":"41","author":"Ennis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/dmrr.689","article-title":"Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy","volume":"23","author":"Chen","year":"2007","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib29","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.HYP.0000102863.23854.0B","article-title":"Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes","volume":"42","author":"Karmazyn","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib30","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1210\/en.2003-0039","article-title":"Mineralocorticoid action and sodium\u2013hydrogen exchange: studies in experimental cardiac fibrosis","volume":"144","author":"Young","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/BF00879877","article-title":"Effects of Na+\u2013H+ exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats","volume":"9","author":"Hasegawa","year":"1995","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib32","first-page":"201","article-title":"Beneficial effect of amiloride, a Na+\u2013H+ exchange blocker, in a murine model of dilated cardiomyopathy","volume":"92","author":"Taniguchi","year":"1996","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib33","first-page":"H300","article-title":"Na+\/H+ exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium","volume":"278","author":"Yoshida","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib34","first-page":"H738","article-title":"Na+\/H+ exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats","volume":"280","author":"Kusumoto","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib35","first-page":"H381","article-title":"Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition","volume":"286","author":"Chen","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cardiores.2004.04.014","article-title":"Inhibition of the Na+\/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits","volume":"63","author":"Aker","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.HYP.0000051502.93374.1C","article-title":"Regression of hypertensive myocardial fibrosis by Na+\/H+ exchange inhibition","volume":"41","author":"Cingolani","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0022-3565(24)29404-0","article-title":"Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+\u2013H+ exchange inhibitor cariporide","volume":"298","author":"Chen","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib39","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/HYPERTENSIONAHA.107.087759","article-title":"Phosphodiesterase 5A inhibition induces Na+\/H+ exchanger blockade and protection against myocardial infarction","volume":"49","author":"P\u00e9rez","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib40","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0022-2828(95)90128-0","article-title":"Altered Na+\u2013H+-exchange activity in the spontaneously hypertensive rat","volume":"27","author":"Schussheim","year":"1995","journal-title":"J mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib41","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.RES.77.6.1192","article-title":"pHi regulation in the myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na+\u2013H+ exchanger","volume":"77","author":"Perez","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib42","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/01.HYP.31.4.961","article-title":"Enalapril induces regression of cardiac hypertrophy and normalization of pHi regulatory mechanisms","volume":"31","author":"Ennis","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib43","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1161\/01.RES.0000014966.97486.C0","article-title":"Inhibition of Na+\u2013H+ exchange prevents hypertrophy, fibrosis, and heart failure in \u03b21-adrenergic receptor transgenic mice","volume":"90","author":"Engelhardt","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.yjmcc.2005.01.003","article-title":"NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor","volume":"38","author":"Chahine","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib45","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/CIRCULATIONAHA.105.542209","article-title":"Enhanced activity of the myocardial Na+\/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice","volume":"112","author":"Kili\u0107","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib46","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1210\/en.2007-0182","article-title":"Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling","volume":"148","author":"Kili\u0107","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib47","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1161\/01.CIR.98.24.2760","article-title":"Atrial natriuretic peptide has different effects on contractility and intracellular pH in normal and hypertrophied myocytes from pressure-overloaded hearts","volume":"98","author":"Tajima","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib48","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00125-007-0628-x","article-title":"Enhanced activity of the myocardial Na+\/H+ exchanger contributes to left ventricular hypertrophy in the Goto\u2013Kakizaki rat model of type 2 diabetes: critical role of Akt","volume":"50","author":"Darmellah","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib49","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.yjmcc.2006.07.001","article-title":"Contribution of NHE-1 to cell shortening of normal and failing rabbit heart","volume":"41","author":"Van Borren","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib50","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1006\/jmcc.1999.0993","article-title":"Na+ influx via Na+\/H+ exchange activates protein kinase C isozymes \u03b4 and \u03b5 in cultured neonatal rat cardiac myocytes","volume":"31","author":"Hayasaki-Kajiwara","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1139\/y06-072","article-title":"Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+\/H+ exchanger 1 inhibition","volume":"85","author":"Ennis","year":"2007","journal-title":"Can J Physiol Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib52","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.yjmcc.2006.05.016","article-title":"Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: involvement of Na+\/H+ and Na+\/Ca2+ exchangers","volume":"41","author":"Dulce","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib53","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1161\/01.CIR.0000016701.85760.97","article-title":"Intracellular Na+ concentration is elevated in heart failure but Na\/K pump function is unchanged","volume":"105","author":"Despa","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000103747","article-title":"Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection","volume":"20","author":"Javadov","year":"2007","journal-title":"Cell Physiol Biochem."},{"key":"10.1016\/j.yjmcc.2008.01.005_bib55","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yjmcc.2004.10.007","article-title":"NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat","volume":"38","author":"Javadov","year":"2005","journal-title":"J Mol Cell Cardiol."},{"issue":"Pt 2","key":"10.1016\/j.yjmcc.2008.01.005_bib56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/0264-6021:3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib57","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.RES.0000087542.26971.D4","article-title":"Role of the mitochondrial permeability transition in myocardial disease","volume":"93","author":"Weiss","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib58","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib59","first-page":"H1722","article-title":"NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling","volume":"291","author":"Javadov","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib60","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/cvr\/cvm039","article-title":"NHE-1 inhibition-induced cardioprotection against ischemia\/reperfusion is associated with attenuation of the mitochondrial permeability transition","volume":"77","author":"Javadov","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib61","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1124\/jpet.105.100107","article-title":"Antihypertrophic effect of Na+\/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species","volume":"317","author":"Javadov","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib62","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/01.CIR.101.25.2902","article-title":"Cardioprotective effects of the Na+\/H+ exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA","volume":"101","author":"Rupprecht","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib63","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.102.25.3032","article-title":"Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial","volume":"102","author":"Th\u00e9roux","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.01.005_bib64","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0735-1097(01)01608-4","article-title":"The Na+\/H+ exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction: results of the Evaluation of the Safety and Cardioprotective effects of eniporide in Acute Myocardial Infarction (ESCAMI) trial","volume":"38","author":"Zeymer","year":"2001","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.yjmcc.2008.01.005_bib65","first-page":"2723","article-title":"Effects of Na+\/H+ exchange inhibition by cariporide on death and nonfatal myocardial infarction in patients undergoing coronary artery bypass gradt surgery: the Expedition study","volume":"108","author":"Mentzer","year":"2003","journal-title":"Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282808000357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282808000357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T10:34:47Z","timestamp":1737974087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282808000357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0022282808000357"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2008.01.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}