{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:39:24Z","timestamp":1792658364836,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.yjmcc.2008.09.002","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T04:21:00Z","timestamp":1221884460000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure"],"prefix":"10.1016","volume":"46","author":[{"given":"Jeffery D.","family":"Molkentin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yjmcc.2008.09.002_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/01.CIR.0000111581.15521.F5","article-title":"Manipulating cardiac contractility in heart failure: data from mice and men","volume":"109","author":"Dorn","year":"2004","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib2","doi-asserted-by":"crossref","unstructured":"Moga MA, Nakamura T, Robbins J. Genetic approaches for changing the heart and dissecting complex syndromes. J Mol Cell Cardiol 2008 in press.","DOI":"10.1016\/j.yjmcc.2008.06.002"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib3","doi-asserted-by":"crossref","first-page":"22419","DOI":"10.1016\/S0021-9258(18)54589-0","article-title":"Myosin heavy chain gene expression in mouse embryoid bodies: an in vitro developmental study","volume":"266","author":"S\u00e1nchez","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib4","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/01.RES.68.6.1742","article-title":"Cardiac myosin expression in the mouse heart","volume":"69","author":"Ng","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/(SICI)1521-2254(199909\/10)1:5<372::AID-JGM61>3.0.CO;2-T","article-title":"Controlling genes with tetracyclines","volume":"1","author":"Bujard","year":"1999","journal-title":"J. Gene. Med."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/0958-1669(94)90067-1","article-title":"Inducible gene expression systems for higher eukaryotic cells","volume":"5","author":"Gossen","year":"1994","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80533-4","article-title":"Inducible and reversible gene expression with the rtTA system for the study of memory","volume":"21","author":"Mansuy","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.RES.0000065442.64694.9F","article-title":"Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter","volume":"92","author":"Sanbe","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/0470029331.ch10","article-title":"Phospholamban as a therapeutic modality in heart failure","volume":"274","author":"Chu","year":"2006","journal-title":"Novartis. Found. Symp."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1172\/JCI118390","article-title":"Molecular medicine in genetically engineered animals: series introduction","volume":"97","author":"Chien","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1161\/01.RES.88.6.546","article-title":"To Cre or not to Cre: the next generation of mouse models of human cardiac diseases","volume":"88","author":"Chien","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/j.1460-2075.1995.tb07101.x","article-title":"Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development","volume":"14","author":"Braun","year":"1995","journal-title":"Embo. J."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib13","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1242\/dev.121.10.3347","article-title":"Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome","volume":"121","author":"Patapoutian","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1101\/gad.9.11.1388","article-title":"Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies","volume":"9","author":"Zhang","year":"1995","journal-title":"Genes. Dev."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","article-title":"Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo","volume":"100","author":"Agah","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib17","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000215985.18538.c4","article-title":"Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability","volume":"98","author":"Oka","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.RES.83.4.345","article-title":"\u201cStress-responsive\u201d mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium","volume":"24","author":"Sugden","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib20","doi-asserted-by":"crossref","first-page":"28092","DOI":"10.1074\/jbc.270.47.28092","article-title":"The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes","volume":"270","author":"Gillespie-Brown","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/01.HYP.35.1.188","article-title":"Endothelin-dependent and -independent components of strain-activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase","volume":"35","author":"Liang","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib22","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/01.RES.78.6.954","article-title":"Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes","volume":"78","author":"Glennon","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1083\/jcb.142.2.523","article-title":"Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?","volume":"142","author":"Clerk","year":"1998","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib24","doi-asserted-by":"crossref","first-page":"H1635","DOI":"10.1152\/ajpheart.2000.279.4.H1635","article-title":"Significance of ERK cascade compared with JAK\/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy","volume":"279","author":"Kodama","year":"2000","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib25","doi-asserted-by":"crossref","first-page":"37895","DOI":"10.1074\/jbc.M007037200","article-title":"Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy","volume":"275","author":"Yue","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1006\/jmcc.2000.1135","article-title":"Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy","volume":"32","author":"Ueyama","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib27","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1083\/jcb.126.6.1565","article-title":"Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy","volume":"126","author":"Thorburn","year":"1994","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib28","doi-asserted-by":"crossref","first-page":"30580","DOI":"10.1016\/S0021-9258(18)43853-7","article-title":"Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy","volume":"269","author":"Thorburn","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib29","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1074\/jbc.271.14.8452","article-title":"Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes","volume":"271","author":"Post","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1091\/mbc.6.11.1479","article-title":"Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase","volume":"6","author":"Thorburn","year":"1995","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib31","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1074\/jbc.272.22.14057","article-title":"The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and Ras activation and is associated with in vitro and in vivo cardiac hypertrophy","volume":"272","author":"Ramirez","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.139.1.115","article-title":"A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression","volume":"139","author":"Zechner","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib33","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI3512","article-title":"Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy","volume":"102","author":"Choukroun","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib34","doi-asserted-by":"crossref","first-page":"24858","DOI":"10.1074\/jbc.274.35.24858","article-title":"Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes","volume":"274","author":"Silberbach","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib35","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"Bueno","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib36","doi-asserted-by":"crossref","first-page":"23173","DOI":"10.1074\/jbc.270.39.23173","article-title":"Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice","volume":"270","author":"Hunter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib37","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1161\/01.CIR.0000127126.73759.23","article-title":"MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo","volume":"109","author":"Lips","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib38","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.88.1.88","article-title":"The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo","volume":"88","author":"Bueno","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib40","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.CIR.0000138190.50127.6A","article-title":"Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload","volume":"110","author":"Harris","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib41","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1242\/jcs.115.8.1575","article-title":"Extracellular signal regulated kinase (ERK)\/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases","volume":"115","author":"Hindley","year":"2002","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib42","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.febslet.2005.03.024","article-title":"Second nature: biological functions of the Raf-1 \u201ckinase\u201d","volume":"579","author":"Baccarini","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.pharmtox.48.121806.154902","article-title":"PKC isozymes in chronic cardiac disease: possible therapeutic targets?","volume":"48","author":"Churchill","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrd1009","article-title":"Kinases as therapeutic targets for heart failure","volume":"2","author":"Vlahos","year":"2003","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib45","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/CIRCULATIONAHA.105.592550","article-title":"Pharmacological- and gene therapy-based inhibition of protein kinase Calpha\/beta enhances cardiac contractility and attenuates heart failure","volume":"114","author":"Hambleton","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib46","doi-asserted-by":"crossref","first-page":"H2500","DOI":"10.1152\/ajpheart.2001.281.6.H2500","article-title":"Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1","volume":"281","author":"Pass","year":"2001","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib47","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/01.RES.81.3.404","article-title":"Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity","volume":"81","author":"Ping","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/CIRCRESAHA.107.148288","article-title":"Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure","volume":"101","author":"Belin","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm1000","article-title":"PKC\u03b1 regulates cardiac contractility and propensity towards heart failure","volume":"10","author":"Braz","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.yjmcc.2007.05.021","article-title":"Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue","volume":"43","author":"El-Armouche","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.0000105087.79373.17","article-title":"Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy","volume":"93","author":"Hahn","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib52","doi-asserted-by":"crossref","first-page":"H3768","DOI":"10.1152\/ajpheart.00486.2007","article-title":"Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure","volume":"293","author":"Hambleton","year":"2007","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib53","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.7761854","article-title":"Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor","volume":"268","author":"Koch","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib54","doi-asserted-by":"crossref","first-page":"18180","DOI":"10.1074\/jbc.273.29.18180","article-title":"Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice","volume":"273","author":"Rockman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib55","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.95.12.7000","article-title":"Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice","volume":"95","author":"Rockman","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib56","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1073\/pnas.091102398","article-title":"Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure","volume":"98","author":"Harding","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1172\/JCI12083","article-title":"Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy","volume":"107","author":"Freeman","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib58","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib59","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.RES.0000069685.20258.F1","article-title":"Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release","volume":"92","author":"Maier","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1210\/me.2002-0350","article-title":"Pressure overload selectively up-regulates Ca2+\/calmodulin-dependent protein kinase II in vivo","volume":"17","author":"Colomer","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.yjmcc.2008.09.002_bib61","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI8551","article-title":"CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo","volume":"105","author":"Passier","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI200316326","article-title":"Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+\/calmodulin kinase II","volume":"111","author":"Zhu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib63","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2008.09.002_bib64","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm1215","article-title":"Calmodulin kinase II inhibition protects against structural heart disease","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib65","doi-asserted-by":"crossref","first-page":"H3065","DOI":"10.1152\/ajpheart.00353.2006","article-title":"Anderson ME. Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo","volume":"291","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2008.09.002_bib66","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1152\/japplphysiol.01045.2001","article-title":"Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains","volume":"92","author":"Lerman","year":"2002","journal-title":"J. Appl. Physiol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282808005841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282808005841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:16:12Z","timestamp":1758312972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282808005841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0022282808005841"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2008.09.002","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2008.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}