{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:31:41Z","timestamp":1790832701103,"version":"4.1.0"},"reference-count":112,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.yjmcc.2009.04.004","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T08:16:18Z","timestamp":1239869778000},"page":"15-22","source":"Crossref","is-referenced-by-count":122,"title":["NADPH oxidase signaling and cardiac myocyte function"],"prefix":"10.1016","volume":"47","author":[{"given":"Ashwin","family":"Akki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2009.04.004_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","article-title":"Oxidant signals and oxidative stress","volume":"15","author":"Finkel","year":"2003","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure","volume":"115","author":"Giordano","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/ars.2006.8.691","article-title":"NADPH oxidases in cardiovascular health and disease","volume":"8","author":"Cave","year":"2006","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib6","doi-asserted-by":"crossref","first-page":"18583","DOI":"10.1074\/jbc.M310268200","article-title":"Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)","volume":"279","author":"Banfi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib7","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/hh0901.090299","article-title":"Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways","volume":"88","author":"Lassegue","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/01.RES.87.1.26","article-title":"A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall","volume":"87","author":"Gorlach","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib9","doi-asserted-by":"crossref","first-page":"19952","DOI":"10.1074\/jbc.M110073200","article-title":"Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells","volume":"277","author":"Li","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hc0302.103712","article-title":"Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice","volume":"105","author":"Bendall","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiolgenomics.00029.2005","article-title":"Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy","volume":"26","author":"Hingtgen","year":"2006","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib12","doi-asserted-by":"crossref","first-page":"C926","DOI":"10.1152\/ajpcell.00254.2001","article-title":"Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes","volume":"282","author":"Xiao","year":"2002","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib13","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1073\/pnas.94.26.14483","article-title":"Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II","volume":"94","author":"Pagano","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/01.RES.0000020404.01971.2F","article-title":"Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II","volume":"90","author":"Touyz","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000105680.92873.70","article-title":"Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase","volume":"109","author":"Ago","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.ATV.0000112024.13727.2c","article-title":"Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells","volume":"24","author":"Hilenski","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.RES.0000099504.30207.F5","article-title":"Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy","volume":"93","author":"Byrne","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib18","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1091\/mbc.E05-06-0532","article-title":"The NADPH oxidase NOX4 drives cardiac differentiation: role in regulating cardiac transcription factors and MAP kinase activation","volume":"17","author":"Li","year":"2006","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib19","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","article-title":"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"97","author":"Cucoranu","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2006.10.054","article-title":"NOX5 variants are functionally active in endothelial cells","volume":"42","author":"BelAiba","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.freeradbiomed.2008.04.024","article-title":"Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells","volume":"45","author":"Jay","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib22","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1152\/ajpregu.00758.2002","article-title":"Vascular NAD(P)H oxidases: specific features, expression, and regulation","volume":"285","author":"Lassegue","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cardiores.2006.02.033","article-title":"Reactive oxygen species signaling in vascular smooth muscle cells","volume":"71","author":"Clempus","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib24","first-page":"3168","article-title":"Redox sensitive signaling pathways in cardiac remodeling, hypertrophy and failure","volume":"14","author":"Narayana","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1089\/152308603770380115","article-title":"Role of NADPH oxidases in the control of vascular gene expression","volume":"5","author":"Brandes","year":"2003","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib26","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/01.RES.0000017631.28815.8E","article-title":"PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells","volume":"90","author":"Frey","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib27","doi-asserted-by":"crossref","first-page":"12094","DOI":"10.1074\/jbc.M209793200","article-title":"Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib28","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/01.RES.0000046227.65158.F8","article-title":"Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis","volume":"91","author":"Ushio-Fukai","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/hh0202.103615","article-title":"Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha","volume":"90","author":"Li","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib30","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1161\/CIRCULATIONAHA.105.581397","article-title":"Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase","volume":"113","author":"Zhang","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/CIRCRESAHA.107.151076","article-title":"Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3","volume":"101","author":"Miller","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/MCB.26.1.140-154.2006","article-title":"Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes","volume":"26","author":"Li","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib33","doi-asserted-by":"crossref","first-page":"45935","DOI":"10.1074\/jbc.M406486200","article-title":"Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase","volume":"279","author":"Ambasta","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2005.03.023","article-title":"Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases","volume":"18","author":"Martyn","year":"2006","journal-title":"Cell. Signal"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib35","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200709049","article-title":"Regulation of ROS signal transduction by NADPH oxidase 4 localization","volume":"181","author":"Chen","year":"2008","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib36","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.24.5.1844-1854.2004","article-title":"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction","volume":"24","author":"Mahadev","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib37","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/ATVBAHA.108.164277","article-title":"Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation","volume":"28","author":"Anilkumar","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib38","first-page":"993","article-title":"Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases","volume":"9","author":"Gupte","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib39","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1042\/BST0340960","article-title":"Redox signaling involving NADPH oxidase-derived reactive oxygen species","volume":"34","author":"Dworakowski","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/ars.2006.1446","article-title":"Redox control of calcium channels: from mechanisms to therapeutic opportunities","volume":"9","author":"Hool","year":"2007","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cardiores.2006.02.019","article-title":"Redox regulation of cardiac calcium channels and transporters","volume":"71","author":"Zima","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib42","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/01.RES.0000115554.65513.7C","article-title":"NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release","volume":"94","author":"Cherednichenko","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib43","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.yjmcc.2005.08.010","article-title":"Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle","volume":"39","author":"Sanchez","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib44","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/cvr\/cvm011","article-title":"Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection","volume":"77","author":"Sanchez","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib45","doi-asserted-by":"crossref","first-page":"H1136","DOI":"10.1152\/ajpheart.00296.2005","article-title":"Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle","volume":"290","author":"Yi","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib46","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1124\/jpet.108.140301","article-title":"Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)H oxidase-derived superoxide","volume":"326","author":"Zeng","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1113\/jphysiol.2005.090639","article-title":"Modulation of potassium currents by angiotensin and oxidative stress in cardiac cells from the diabetic rat","volume":"567","author":"Shimoni","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/cvr\/cvm031","article-title":"Regulation of swelling-activated Cl(\u2212) current by angiotensin II signaling and NADPH oxidase in rabbit ventricle","volume":"77","author":"Ren","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib49","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/01.RES.0000218989.52072.e7","article-title":"Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA","volume":"98","author":"Zhou","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib50","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/01.RES.0000268497.93085.e1","article-title":"Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes","volume":"100","author":"Tsai","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib51","doi-asserted-by":"crossref","first-page":"C372","DOI":"10.1152\/ajpcell.00186.2007","article-title":"NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II","volume":"294","author":"Shang","year":"2008","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib52","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signaling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib53","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/01.CIR.98.8.794","article-title":"Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II","volume":"98","author":"Nakamura","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib54","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/hc0402.102863","article-title":"Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy","volume":"105","author":"Hirotani","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib56","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0735-1097(03)00471-6","article-title":"Increased myocardial NADPH oxidase activity in human heart failure","volume":"41","author":"Heymes","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib57","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000091084.46500.BB","article-title":"Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment","volume":"108","author":"Maack","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib58","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.yjmcc.2007.01.009","article-title":"NADPH oxidase-dependent redox signaling in human heart failure: relationship between the left and right ventricle","volume":"42","author":"Nediani","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib59","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1073\/pnas.0510444103","article-title":"Requirement of Rac1 in the development of cardiac hypertrophy","volume":"103","author":"Satoh","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib60","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1172\/JCI8497","article-title":"Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1","volume":"105","author":"Sussman","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI2552","article-title":"A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy","volume":"102","author":"Pracyk","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib62","doi-asserted-by":"crossref","first-page":"20770","DOI":"10.1074\/jbc.M213203200","article-title":"The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B","volume":"278","author":"Higuchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib63","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/01.CIR.0000117229.60628.2F","article-title":"Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox","volume":"109","author":"Maytin","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib64","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmcc.2001.1348","article-title":"MEK1\/2-ERK1\/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes","volume":"33","author":"Xiao","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib65","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.CIR.0000157148.59308.F5","article-title":"Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras","volume":"111","author":"Kuster","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib66","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-2828(03)00145-7","article-title":"NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy","volume":"35","author":"Nakagami","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib67","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.RES.0000100665.67510.F5","article-title":"Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling","volume":"93","author":"Izumiya","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib68","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1089\/ars.2005.7.472","article-title":"Stress-responsive protein kinases in redox-regulated apoptosis signaling","volume":"7","author":"Matsuzawa","year":"2005","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib69","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/01.hco.0000231397.64362.70","article-title":"Apoptosis in hypertensive heart disease: a clinical approach","volume":"21","author":"Gonzalez","year":"2006","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib70","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1161\/01.RES.0000148632.35500.d9","article-title":"The mitochondrial death pathway and cardiac myocyte apoptosis","volume":"95","author":"Crow","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib71","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2005.08.010","article-title":"NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin","volume":"40","author":"Qin","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2007.04.021","article-title":"Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction","volume":"43","author":"Qin","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib73","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.gt.3303071","article-title":"Overexpression of TGFbeta1 by adeno-associated virus type-2 vector protects myocardium from ischemia-reperfusion injury","volume":"15","author":"Dandapat","year":"2008","journal-title":"Gene. Ther."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib74","doi-asserted-by":"crossref","first-page":"H2364","DOI":"10.1152\/ajpheart.00408.2003","article-title":"Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage","volume":"285","author":"Grishko","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib75","doi-asserted-by":"crossref","first-page":"H1847","DOI":"10.1152\/ajpheart.00578.2007","article-title":"Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis","volume":"293","author":"Li","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib76","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1291\/hypres.31.363","article-title":"Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis","volume":"31","author":"Hayashi","year":"2008","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib77","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00004872-200018060-00002","article-title":"Role of oxidative stress in cardiovascular diseases","volume":"18","author":"Dhalla","year":"2000","journal-title":"J. Hypertens."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib78","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/S0021-9258(18)52251-1","article-title":"Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes","volume":"266","author":"Josephson","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib79","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1161\/01.CIR.94.10.2597","article-title":"Selective effects of oxygen free radicals on excitation\u2013contraction coupling in ventricular muscle. Implications for the mechanism of stunned myocardium","volume":"94","author":"Gao","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib80","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/01.RES.82.8.891","article-title":"Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation","volume":"82","author":"Xie","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib81","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.RES.87.5.392","article-title":"Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress","volume":"87","author":"Kinugawa","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib82","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","article-title":"Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction","volume":"88","author":"Ide","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib83","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1024145212616","article-title":"Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum","volume":"248","author":"Kaplan","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib84","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1161\/CIRCULATIONAHA.105.555623","article-title":"Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure","volume":"112","author":"Yano","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib85","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jacc.2005.09.051","article-title":"Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload","volume":"47","author":"Grieve","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib86","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s00125-006-0229-0","article-title":"Cardiac contractile dysfunction in Lep\/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch","volume":"49","author":"Li","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib87","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.freeradbiomed.2005.12.009","article-title":"Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme","volume":"40","author":"Wold","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib88","doi-asserted-by":"crossref","first-page":"H1728","DOI":"10.1152\/ajpheart.01328.2005","article-title":"Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-l-cysteine","volume":"292","author":"Guo","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib89","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1096\/fj.05-5288fje","article-title":"Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress","volume":"20","author":"Yang","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib90","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/01.CIR.0000160366.50210.E9","article-title":"Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression","volume":"111","author":"Peng","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib91","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1161\/hc4901.100382","article-title":"Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase","volume":"104","author":"MacCarthy","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib92","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1096\/fj.05-4642fje","article-title":"Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase","volume":"20","author":"Johar","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib93","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart: role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib94","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bbrc.2003.11.173","article-title":"NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats","volume":"313","author":"Park","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib95","doi-asserted-by":"crossref","first-page":"E355","DOI":"10.1152\/ajpendo.00632.2006","article-title":"Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat","volume":"293","author":"Whaley-Connell","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib96","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1161\/01.RES.0000077044.60138.7C","article-title":"Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species","volume":"92","author":"Grote","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2004.12.152","article-title":"Angiotensin II induces MMP-2 in a p47phox-dependent manner","volume":"328","author":"Luchtefeld","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib98","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2174\/092986706777585086","article-title":"Targeting the inflammatory response in healing myocardial infarcts","volume":"13","author":"Frangogiannis","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib99","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.hlc.2004.02.008","article-title":"Role of oxidative stress in cardiac remodelling after myocardial infarction","volume":"13","author":"Grieve","year":"2004","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib100","first-page":"291","article-title":"Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats","volume":"148","author":"Hill","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib101","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1161\/01.CIR.0000016721.84535.00","article-title":"Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat","volume":"105","author":"Sia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib102","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1006\/bbrc.2001.4493","article-title":"Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction","volume":"281","author":"Fukui","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib103","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/jcp.56.3.194","article-title":"Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction","volume":"56","author":"Krijnen","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib104","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.RES.0000261657.76299.ff","article-title":"Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling\/dysfunction and survival after myocardial infarction","volume":"100","author":"Doerries","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/HYPERTENSIONAHA.107.101980","article-title":"Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction","volume":"51","author":"Looi","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib106","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib107","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/hh0801.089342","article-title":"Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism","volume":"88","author":"Forbes","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib108","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.87.6.460","article-title":"Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals","volume":"87","author":"Pain","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib109","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.abb.2003.09.023","article-title":"Preconditioning potentiates redox signaling and converts death signal into survival signal","volume":"420","author":"Das","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib110","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1096\/fj.04-2774fje","article-title":"Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning","volume":"19","author":"Bell","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2009.04.004_bib111","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/01.HYP.0000163462.98381.7f","article-title":"Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II","volume":"45","author":"Kimura","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2009.04.004_bib112","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1385\/CBB:44:1:103","article-title":"Angiotensin preconditioning of the heart: evidence for redox signaling","volume":"44","author":"Das","year":"2006","journal-title":"Cell. Biochem. Biophys."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809001527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809001527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T05:34:03Z","timestamp":1633325643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282809001527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0022282809001527"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2009.04.004","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}