{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:59:54Z","timestamp":1792515594463,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15590755"],"award-info":[{"award-number":["15590755"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15590759"],"award-info":[{"award-number":["15590759"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17590775"],"award-info":[{"award-number":["17590775"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.yjmcc.2009.08.032","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T08:15:56Z","timestamp":1252484156000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intracellular Ca2+- and PKC-dependent upregulation of T-type Ca2+ channels in LPC-stimulated cardiomyocytes"],"prefix":"10.1016","volume":"48","author":[{"given":"Mingqi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Shimaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Marni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushige","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2009.08.032_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(24)37550-0","article-title":"Mechanisms of lysophosphatidylcholine-induced increase in intracellular calcium in rat cardiomyocytes","volume":"286","author":"Yu","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib2","first-page":"H32","article-title":"Lysophosphatidylcholine potentiates Ca2+ accumulation in rat cardiac myocytes","volume":"244","author":"Sedlis","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib3","first-page":"H187","article-title":"Pathophysiological concentrations of lysophosphatides and the slow response","volume":"243","author":"Corr","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0022-2828(91)90977-T","article-title":"Lysophosphatidylcholine increases cytosolic calcium in ventricular myocytes by direct action on the sarcolemma","volume":"23","author":"Woodley","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib5","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/0024-3205(79)90238-8","article-title":"The inhibition of Na+ and K+ stimulated ATPase activity of rabbit and dog heart sarcolemma by lysophosphatidylcholine","volume":"24","author":"Karli","year":"1979","journal-title":"Life Sci."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000092041","article-title":"Lysophosphatidylcholine augments CaV3.2 but not CaV3.1 T-type Ca2+ channel current expressed in HEK-293 cells","volume":"76","author":"Zheng","year":"2006","journal-title":"Pharmacology"},{"key":"10.1016\/j.yjmcc.2009.08.032_bib7","first-page":"L429","article-title":"Protein kinase C isozymes and the regulation of diverse cell responses","volume":"279","author":"Dempsey","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib8","doi-asserted-by":"crossref","first-page":"H1761","DOI":"10.1152\/ajpheart.2001.280.6.H2761","article-title":"Abnormal Ca and \u03b5PKC signaling in hypertrophied atrial tumor myocytes (AT-1 cells)","volume":"280","author":"Kline","year":"2001","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/01.RES.85.11.1085","article-title":"Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein \u03b1(q)","volume":"85","author":"Mende","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/01.RES.76.4.654","article-title":"Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes","volume":"76","author":"Johnson","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/01.RES.75.6.999","article-title":"Modulation of an inactivating human cardiac K+ channel by protein kinase C","volume":"75","author":"Murray","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.yjmcc.2007.03.905","article-title":"Transcription factors Csx\/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart","volume":"42","author":"Wang","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib13","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbrc.2006.04.146","article-title":"Remodeling excitation\u2013contraction coupling of hypertrophied ventricular myocytes is dependent on T-type calcium channels expression","volume":"345","author":"Takebayashi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0076-6879(88)57093-3","article-title":"Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands","volume":"157","author":"Fabiato","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cardiores.2006.05.023","article-title":"Oxidized low-density lipoprotein depletes PKC\u03b1 and attenuates reactive oxygen species formation in monocytes\/macrophages","volume":"71","author":"Kohl","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/CIRCULATIONAHA.105.592550","article-title":"Pharmacological- and gene therapy-based inhibition of protein kinase C\u03b1\/\u03b2 enhances cardiac contractility and attenuates heart failure","volume":"114","author":"Hambleton","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.08.032_bib17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mce.2006.03.033","article-title":"Role of protein kinase C\u03b1 in melatonin signal transduction","volume":"252","author":"Sampson","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/01.CIR.0000133384.38551.A8","article-title":"Selective inhibition of protein kinase C\u03b22 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"110","author":"Kouroedov","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.08.032_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-5198(19)53291-7","article-title":"Suppression of lysophosphatidylcholine-induced abnormal automaticity by verapamil in canine Purkinje fibers","volume":"36","author":"Nakaya","year":"1984","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib20","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/01.RES.44.6.822","article-title":"Potential arrhythmogenic electrophysiological derangements in canine Purkinje fibers induced by lysophosphoglycerides","volume":"44","author":"Corr","year":"1979","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00640917","article-title":"Effects of lysophosphatidylcholine on resting potassium conductance of isolated guinea pig ventricular cells","volume":"406","author":"Kiyosue","year":"1986","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/01.RES.71.5.1231","article-title":"Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine","volume":"71","author":"Undrovinas","year":"1992","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.ph.55.030193.002323","article-title":"Pacemaker mechanisms in cardiac tissue","volume":"55","author":"DiFrancesco","year":"1993","journal-title":"Ann. Rev. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/cvr\/13.7.377","article-title":"Augmentation of cyclic AMP content induced by lysophosphatidylcholine in rabbit hearts","volume":"13","author":"Ahumada","year":"1979","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/jphysiol.1997.sp021927","article-title":"Elementary and global aspects of calcium signaling","volume":"499","author":"Berridge","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib26","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1139\/y95-242","article-title":"Effects of endothelin 1 on calcium and sodium currents in isolated human cardiac myocytes","volume":"73","author":"Cheng","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1469-7793.1997.055bi.x","article-title":"Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes","volume":"503","author":"Thomas","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s002109900130","article-title":"Characterization of the endothelin-1-induced regulation of L-type Ca2+ current in rabbit ventricular myocytes","volume":"360","author":"Watanabe","year":"1999","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib29","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.RES.87.12.1095","article-title":"Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C","volume":"87","author":"Kamp","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-5793(93)81655-J","article-title":"Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids: subspecies differences","volume":"320","author":"Sasaki","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.2006.123414","article-title":"Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits","volume":"581","author":"Cockerill","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.2001.012839","article-title":"Stimulation of recombinant Cav3.2, T-type, Ca2+ channel currents by CaMKII\u03b3c","volume":"538","author":"Wolfe","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib33","doi-asserted-by":"crossref","first-page":"H184","DOI":"10.1152\/ajpheart.2000.278.1.H184","article-title":"Arachidonic acid modulation of \u03b11H, a cloned human T-type calcium channel","volume":"278","author":"Zhang","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib34","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.RES.71.5.1242","article-title":"Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes","volume":"71","author":"Furukawa","year":"1992","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1523\/JNEUROSCI.10-03-00947.1990","article-title":"T-type calcium channels: heterogeneous expression in rat sensory neurons and selective modulation by phorbol esters","volume":"10","author":"Schroeder","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib36","doi-asserted-by":"crossref","first-page":"C206","DOI":"10.1152\/ajpcell.1988.254.1.C206","article-title":"Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells","volume":"254","author":"Marchetti","year":"1988","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2009.08.032_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-5793(03)00665-3","article-title":"Modulation of Ca(v)3.2 T-type Ca2+ channels by protein kinase C","volume":"547","author":"Park","year":"2003","journal-title":"FEBS Lett."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809003757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809003757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:17:41Z","timestamp":1758313061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282809003757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0022282809003757"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2009.08.032","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular Ca2+- and PKC-dependent upregulation of T-type Ca2+ channels in LPC-stimulated cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2009.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}