{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:16:26Z","timestamp":1772003786863,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.yjmcc.2009.09.012","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T09:22:02Z","timestamp":1254388922000},"page":"810-818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway"],"prefix":"10.1016","volume":"47","author":[{"given":"J. Craig","family":"Hunter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Zeidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabzali","family":"Javadov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Kili\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Rajapurohitam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Karmazyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2009.09.012_bib1","series-title":"2008 Heart and Stroke Statistical Update","year":"2008"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0014-5793(99)00680-8","article-title":"The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes\u2014possible involvement of Rho\/ROCK pathway in cardiac muscle cell hypertrophy","volume":"452","author":"Kuwahara","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib3","doi-asserted-by":"crossref","first-page":"G1006","DOI":"10.1152\/ajpgi.00465.2002","article-title":"Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA","volume":"284","author":"Murthy","year":"2003","journal-title":"Am. J. Physiol., Gastrointest. Liver Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib4","doi-asserted-by":"crossref","first-page":"21722","DOI":"10.1074\/jbc.M000753200","article-title":"Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle","volume":"275","author":"Sauzeau","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib5","doi-asserted-by":"crossref","first-page":"H2598","DOI":"10.1152\/ajpheart.01393.2006","article-title":"Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium","volume":"292","author":"Hamid","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cardiores.2006.06.024","article-title":"Essential role of Rho\/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes","volume":"72","author":"Zeidan","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib7","doi-asserted-by":"crossref","first-page":"H1804","DOI":"10.1152\/ajpheart.01078.2007","article-title":"Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction","volume":"294","author":"Phrommintikul","year":"2008","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/01.RES.82.6.666","article-title":"Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation","volume":"82","author":"Aoki","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1007185711745","article-title":"Rho plays an important role in angiotensin II-induced hypertrophic responses in cardiac myocytes","volume":"212","author":"Aikawa","year":"2000","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/jcp.20151","article-title":"PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes","volume":"202","author":"Pan","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/cvr\/cvm020","article-title":"Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA\/ROCK-dependent p38 MAPK translocation to nuclei","volume":"77","author":"Zeidan","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib12","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1172\/JCI31240","article-title":"Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity","volume":"117","author":"Kuwahara","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cbpb.2005.05.048","article-title":"Regulation of the mammalian heart function by nitric oxide","volume":"142","author":"Massion","year":"2005","journal-title":"Comp. Biochem. Physiol., A Mol. Integr. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.hco.0000221584.56372.dc","article-title":"Nitric oxide signaling in the cardiovascular system: implications for heart failure","volume":"21","author":"Saraiva","year":"2006","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib15","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/hc3601.094298","article-title":"Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice","volume":"104","author":"Scherrer-Crosbie","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib16","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.RES.0000126497.38281.23","article-title":"Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction","volume":"94","author":"Janssens","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib17","doi-asserted-by":"crossref","first-page":"H620","DOI":"10.1152\/ajpheart.01236.2006","article-title":"Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload","volume":"293","author":"Buys","year":"2007","journal-title":"Am. J. Physiol., Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/hc3201.092284","article-title":"Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice","volume":"104","author":"Feng","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib19","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1172\/JCI119883","article-title":"Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts","volume":"101","author":"Calderone","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2210-5-10","article-title":"Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T","volume":"5","author":"Hassan","year":"2005","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"Takimoto","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib22","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1006\/bbrc.2000.4194","article-title":"cGMP-dependent protein kinase phosphorylates and inactivates RhoA","volume":"280","author":"Sawada","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.yjmcc.2006.05.001","article-title":"An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1","volume":"41","author":"Rajapurohitam","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib24","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1074\/jbc.M213066200","article-title":"Serine phosphorylation negatively regulates RhoA in vivo","volume":"278","author":"Ellerbroek","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj3610243","article-title":"Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes","volume":"361","author":"Forget","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.RES.0000216039.75913.9e","article-title":"The Rac and Rho hall of fame: a decade of hypertrophic signaling hits","volume":"98","author":"Brown","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.HYP.27.1.14","article-title":"Chronic l-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats","volume":"27","author":"Matsuoka","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib28","doi-asserted-by":"crossref","first-page":"18596","DOI":"10.1074\/jbc.271.31.18596","article-title":"Mechanism of nitric oxide release from S-nitrosothiols","volume":"271","author":"Singh","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib29","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1161\/CIRCULATIONAHA.105.557892","article-title":"Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium","volume":"112","author":"Saraiva","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12012-007-0028-y","article-title":"eNOS deficient mice develop progressive cardiac hypertrophy with altered cytokine and calcium handling protein expression","volume":"7","author":"Flaherty","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/416337a","article-title":"Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms","volume":"416","author":"Barouch","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/hh1601.094993","article-title":"Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction","volume":"89","author":"Sam","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/01.RES.0000264081.78659.45","article-title":"Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure","volume":"100","author":"Zhang","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib34","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1161\/CIRCULATIONAHA.107.741702","article-title":"Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling","volume":"117","author":"Loyer","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1172\/JCI0213265","article-title":"Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death","volume":"109","author":"Mungrue","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1022142904202","article-title":"Role of nitric oxide in the pathophysiology of heart failure","volume":"8","author":"Champion","year":"2003","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib37","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1161\/CIRCULATIONAHA.107.737031","article-title":"Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy","volume":"117","author":"Moens","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib38","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1124\/mol.105.014449","article-title":"Nitric oxide inhibits endothelin-1-induced cardiomyocyte hypertrophy through cGMP-mediated suppression of extracellular-signal regulated kinase phosphorylation","volume":"68","author":"Cheng","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib39","first-page":"1370","article-title":"Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide","volume":"275","author":"Ritchie","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib40","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/HYPERTENSIONAHA.107.093666","article-title":"LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation","volume":"50","author":"Ruiz-Hurtado","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib41","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib42","doi-asserted-by":"crossref","first-page":"C824","DOI":"10.1152\/ajpcell.00592.2005","article-title":"Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA","volume":"292","author":"Zuckerbraun","year":"2007","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib43","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/bies.20049","article-title":"Nitric oxide and the enigma of cardiac hypertrophy","volume":"26","author":"Kempf","year":"2004","journal-title":"BioEssays"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib44","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/01.CIR.0000055319.94801.FC","article-title":"Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy","volume":"107","author":"Heineke","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2009.09.012_bib45","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1006\/bbrc.2001.6068","article-title":"Reactive oxygen species in mechanical stress-induced cardiac hypertrophy","volume":"289","author":"Aikawa","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib46","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/MCB.21.4.1173-1184.2001","article-title":"Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1","volume":"21","author":"Clerk","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ceb.2005.11.005","article-title":"Cofilin phosphatases and regulation of actin dynamics","volume":"18","author":"Huang","year":"2006","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib48","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1074\/jbc.M411494200","article-title":"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin","volume":"280","author":"Wang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib49","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tcm.2006.03.010","article-title":"Regulation of Rho proteins by phosphorylation in the cardiovascular system","volume":"16","author":"Loirand","year":"2006","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2009.09.012_bib50","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/diabetes.51.7.2256","article-title":"Negative regulation of Rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: role of nitric oxide and cyclic guanosine monophosphate signaling pathways","volume":"51","author":"Begum","year":"2002","journal-title":"Diabetes"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809004118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282809004118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:17:02Z","timestamp":1758313022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282809004118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022282809004118"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2009.09.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2009.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}