{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:43:29Z","timestamp":1788871409343,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"am","delay-in-days":243,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["1R01 AA013412"],"award-info":[{"award-number":["1R01 AA013412"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["09POST2250477"],"award-info":[{"award-number":["09POST2250477"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30700263"],"award-info":[{"award-number":["30700263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30728023"],"award-info":[{"award-number":["30728023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.yjmcc.2010.03.017","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T04:25:07Z","timestamp":1270182307000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases"],"prefix":"10.1016","volume":"49","author":[{"given":"Heng","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Byra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi I.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/eurjhf\/hfp037","article-title":"Alcohol abuse and heart failure","volume":"11","author":"Laonigro","year":"2009","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/ije\/30.4.724","article-title":"Alcohol and coronary heart disease","volume":"30","author":"Marmot","year":"2001","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib3","first-page":"337","article-title":"Effects of alcohol on the heart","volume":"7","author":"Spies","year":"2001","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.yjmcc.2010.03.017_bib4","first-page":"35","article-title":"Alcohol and the myocardium","volume":"216","author":"Richardson","year":"1998","journal-title":"Novartis Found Symp"},{"issue":"9","key":"10.1016\/j.yjmcc.2010.03.017_bib5","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/01.alc.0000179318.48376.cd","article-title":"RSA 2004: combined basic research satellite symposium\u2014session three: alcohol and mitochondrial metabolism: at the crossroads of life and death","volume":"29","author":"Szabo","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.03.017_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10408360290795529","article-title":"Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis","volume":"39","author":"Hannuksela","year":"2002","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.03.017_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.alcohol.2004.01.005","article-title":"Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress","volume":"32","author":"Zhang","year":"2004","journal-title":"Alcohol"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.03.017_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/y83-001","article-title":"Pharmacology of acetaldehyde","volume":"61","author":"Brien","year":"1983","journal-title":"Can J Physiol Pharmacol"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib9","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/alcalc\/35.6.554","article-title":"Influence of chronic alcohol ingestion on acetaldehyde-induced depression of rat cardiac contractile function","volume":"35","author":"Ren","year":"2000","journal-title":"Alcohol Alcohol"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.03.017_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/bbrc.2000.2353","article-title":"Diabetes enhances acetaldehyde-induced depression of cardiac myocyte contraction","volume":"269","author":"Ren","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib11","first-page":"453","article-title":"Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+","volume":"45","author":"Brown","year":"1999","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"10.1016\/j.yjmcc.2010.03.017_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/9780470511848.ch13","article-title":"Acetaldehyde adducts in circulation","volume":"285","author":"Niemela","year":"2007","journal-title":"Novartis Found Symp"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib13","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.yjmcc.2008.02.276","article-title":"Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress","volume":"44","author":"Li","year":"2008","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib14","doi-asserted-by":"crossref","first-page":"H1216","DOI":"10.1152\/ajpheart.00780.2001","article-title":"Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes","volume":"282","author":"Duan","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"14","key":"10.1016\/j.yjmcc.2010.03.017_bib15","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1161\/CIRCULATIONAHA.108.823799","article-title":"Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction","volume":"119","author":"Doser","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.03.017_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yjmcc.2005.11.006","article-title":"Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling","volume":"40","author":"Li","year":"2006","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2010.03.017_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1566-0702(02)00206-0","article-title":"Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects","volume":"102","author":"Nishimura","year":"2002","journal-title":"Auton Neurosci"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.03.017_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/dmd.30.1.69","article-title":"Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver","volume":"30","author":"Wang","year":"2002","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.yjmcc.2010.03.017_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/15376510903401708","article-title":"Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice","volume":"19","author":"Yu","year":"2009","journal-title":"Toxicol Mech Methods"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.03.017_bib20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0014-5793(00)01710-5","article-title":"Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse","volume":"476","author":"Kitagawa","year":"2000","journal-title":"FEBS Lett"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib21","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1152\/japplphysiol.00750.2005","article-title":"Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes","volume":"99","author":"Zhang","year":"2005","journal-title":"J Appl Physiol"},{"issue":"7","key":"10.1016\/j.yjmcc.2010.03.017_bib22","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1097\/01.ALC.0000075823.73536.DD","article-title":"Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion","volume":"27","author":"Hintz","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"issue":"12","key":"10.1016\/j.yjmcc.2010.03.017_bib23","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/oby.2007.350","article-title":"Interaction between high-fat diet and alcohol dehydrogenase on ethanol-elicited cardiac depression in murine myocytes","volume":"15","author":"Ren","year":"2007","journal-title":"Obesity (Silver Spring)"},{"issue":"12","key":"10.1016\/j.yjmcc.2010.03.017_bib24","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.jacc.2005.02.075","article-title":"Alcohol and the cardiovascular system research challenges and opportunities","volume":"45","author":"Lucas","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2010.03.017_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1995.sp020786","article-title":"Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition","volume":"486","author":"Di Lisa","year":"1995","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.03.017_bib26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/bbrc.1999.0944","article-title":"Hypertension augments ethanol-induced depression of cell shortening and intracellular Ca(2+) transients in adult rat ventricular myocytes","volume":"261","author":"Ren","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.03.017_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmet.2008.01.004","article-title":"Phosphatases at the heart of FoxO metabolic control","volume":"7","author":"Tremblay","year":"2008","journal-title":"Cell Metab"},{"issue":"51","key":"10.1016\/j.yjmcc.2010.03.017_bib28","doi-asserted-by":"crossref","first-page":"20517","DOI":"10.1073\/pnas.0610290104","article-title":"FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases","volume":"104","author":"Ni","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.03.017_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellsig.2006.05.032","article-title":"Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1","volume":"19","author":"Zuluaga","year":"2007","journal-title":"Cell Signal"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/01.ALC.0000163493.45344.7A","article-title":"Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization","volume":"29","author":"Hajnoczky","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00001648-199009000-00003","article-title":"Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study","volume":"1","author":"Boffetta","year":"1990","journal-title":"Epidemiology"},{"issue":"11","key":"10.1016\/j.yjmcc.2010.03.017_bib32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jacc.2007.04.089","article-title":"Alcohol and cardiovascular health: the razor-sharp double-edged sword","volume":"50","author":"O'Keefe","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1530-0277.2009.01138.x","article-title":"Ethanol-induced increase of Agouti-related protein (AgRP) immunoreactivity in the arcuate nucleus of the hypothalamus of C57BL\/6J, but not 129\/SvJ, inbred mice","volume":"34","author":"Cubero","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.03.017_bib34","doi-asserted-by":"crossref","first-page":"e8757","DOI":"10.1371\/journal.pone.0008757","article-title":"Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway","volume":"5","author":"Guo","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.03.017_bib35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1530-0277.2008.00844.x","article-title":"Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication","volume":"33","author":"Walker","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib36","first-page":"410","article-title":"ECG changes in alcoholic intoxication","volume":"54","author":"Trejbal","year":"2008","journal-title":"Vnitr Lek"},{"issue":"23","key":"10.1016\/j.yjmcc.2010.03.017_bib37","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.jacc.2009.04.100","article-title":"Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor","volume":"54","author":"Ma","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.03.017_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1540-8159.1988.tb06002.x","article-title":"Sudden death associated with alcohol consumption","volume":"11","author":"Panos","year":"1988","journal-title":"Pacing Clin Electrophysiol"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/1753944708095137","article-title":"Mechanisms of alcoholic heart disease","volume":"2","author":"Ren","year":"2008","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"7","key":"10.1016\/j.yjmcc.2010.03.017_bib40","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: a dysfunctional relationship","volume":"122","author":"Hoek","year":"2002","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/PL00002037","article-title":"Alcohol and the heart","volume":"26","author":"Schoppet","year":"2001","journal-title":"Herz"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.03.017_bib42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1161\/CIRCRESAHA.107.168211","article-title":"Protein kinase d in the cardiovascular system: emerging roles in health and disease","volume":"102","author":"Avkiran","year":"2008","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib43","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/alcalc\/agl080","article-title":"Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase","volume":"41","author":"Li","year":"2006","journal-title":"Alcohol Alcohol"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.03.017_bib44","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1046\/j.1471-4159.2003.02113.x","article-title":"Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation","volume":"87","author":"Bijur","year":"2003","journal-title":"J Neurochem"},{"issue":"Pt 16","key":"10.1016\/j.yjmcc.2010.03.017_bib45","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1242\/jcs.03473","article-title":"GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis","volume":"120","author":"Lin","year":"2007","journal-title":"J Cell Sci"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib46","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/diabetes.50.5.1171","article-title":"Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis. Role of GSK3beta","volume":"50","author":"Hall","year":"2001","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.yjmcc.2010.03.017_bib47","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10495-009-0398-7","article-title":"Activation of Akt\/GSK-3beta signaling pathway is involved in intermedin(1\u201353) protection against myocardial apoptosis induced by ischemia\/reperfusion","volume":"14","author":"Song","year":"2009","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.yjmcc.2010.03.017_bib48","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1172\/JCI19906","article-title":"Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore","volume":"113","author":"Juhaszova","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.03.017_bib49","doi-asserted-by":"crossref","first-page":"H569","DOI":"10.1152\/ajpheart.00293.2009","article-title":"Molecular mechanism underlying Akt activation in zinc-induced cardioprotection","volume":"297","author":"Lee","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.03.017_bib50","first-page":"339","article-title":"Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother","volume":"92","author":"Espinet","year":"1984","journal-title":"Arch Int Physiol Biochim"},{"key":"10.1016\/j.yjmcc.2010.03.017_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/9780470511848.ch5","article-title":"Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models","volume":"285","author":"Ren","year":"2007","journal-title":"Novartis Found Symp"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282810001276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282810001276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:57:31Z","timestamp":1762667851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282810001276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0022282810001276"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2010.03.017","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2010.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}