{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:28Z","timestamp":1791354088194,"version":"4.3.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.yjmcc.2010.10.008","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T08:24:21Z","timestamp":1287735861000},"page":"512-517","source":"Crossref","is-referenced-by-count":74,"title":["Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure"],"prefix":"10.1016","volume":"51","author":[{"given":"Christopher C.","family":"Glembotski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.yjmcc.2010.10.008_bb0005","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1161\/CIRCULATIONAHA.108.767673","article-title":"Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart","volume":"117","author":"Oshima","year":"2008","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.yjmcc.2010.10.008_bb0010","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.109.872200","article-title":"Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury","volume":"120","author":"Oshima","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.10.008_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1253\/circj.CJ-08-0961","article-title":"Adipokines, myokines and cardiovascular disease","volume":"73","author":"Walsh","year":"2009","journal-title":"Circ J"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.10.008_bb0020","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/japplphysiol.00080.2007","article-title":"Role of myokines in exercise and metabolism","volume":"103","author":"Pedersen","year":"2007","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.10.008_bb0025","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1010318832604","article-title":"Protein targeting","volume":"20","author":"Blobel","year":"2000","journal-title":"Biosci Rep"},{"key":"10.1016\/j.yjmcc.2010.10.008_bb0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.20.010403.105307","article-title":"Bi-directional protein transport between the ER and Golgi","volume":"20","author":"Lee","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"4200","key":"10.1016\/j.yjmcc.2010.10.008_bb0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.1096303","article-title":"Intracellular aspects of the process of protein synthesis","volume":"189","author":"Palade","year":"1975","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.10.008_bb0040","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1152\/physrev.00015.2006","article-title":"Endoplasmic reticulum stress signaling in disease","volume":"86","author":"Marciniak","year":"2006","journal-title":"Physiol Rev"},{"issue":"10","key":"10.1016\/j.yjmcc.2010.10.008_bb0045","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/CIRCRESAHA.107.161273","article-title":"Endoplasmic reticulum stress in the heart","volume":"101","author":"Glembotski","year":"2007","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.10.008_bb0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/13813450802306602","article-title":"Hypoxia and the endocrine and signalling role of white adipose tissue","volume":"114","author":"Trayhurn","year":"2008","journal-title":"Arch Physiol Biochem"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.10.008_bb0055","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI32752","article-title":"Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents","volume":"118","author":"Ota","year":"2008","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.yjmcc.2010.10.008_bb0060","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/scdb.1999.0317","article-title":"Procollagen folding and assembly: the role of endoplasmic reticulum enzymes and molecular chaperones","volume":"10","author":"Lamande","year":"1999","journal-title":"Semin Cell Dev Biol"},{"issue":"21","key":"10.1016\/j.yjmcc.2010.10.008_bb0065","doi-asserted-by":"crossref","first-page":"14884","DOI":"10.1074\/jbc.274.21.14884","article-title":"Intracellular retention of procollagen within the endoplasmic reticulum is mediated by prolyl 4-hydroxylase","volume":"274","author":"Walmsley","year":"1999","journal-title":"J Biol Chem"},{"issue":"23","key":"10.1016\/j.yjmcc.2010.10.008_bb0070","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.1128\/MCB.00947-08","article-title":"Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress","volume":"28","author":"Verras","year":"2008","journal-title":"Mol Cell Biol"},{"issue":"16","key":"10.1016\/j.yjmcc.2010.10.008_bb0075","doi-asserted-by":"crossref","first-page":"8584","DOI":"10.1073\/pnas.93.16.8584","article-title":"Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia","volume":"93","author":"Kuznetsov","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.yjmcc.2010.10.008_bb0080","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.10.008_bb0085","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.semcdb.2007.09.003","article-title":"The endoplasmic reticulum and the unfolded protein response","volume":"18","author":"Malhotra","year":"2007","journal-title":"Semin Cell Dev Biol"},{"issue":"9","key":"10.1016\/j.yjmcc.2010.10.008_bb0090","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/bies.10320","article-title":"Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD)","volume":"25","author":"McCracken","year":"2003","journal-title":"Bioessays"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.10.008_bb0095","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.yjmcc.2007.10.017","article-title":"The role of the unfolded protein response in the heart","volume":"44","author":"Glembotski","year":"2008","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"10.1016\/j.yjmcc.2010.10.008_bb0100","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.yjmcc.2010.10.008_bb0105","doi-asserted-by":"crossref","unstructured":"Mori K. Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein! Mol Biol Cell, 2010 May; 21(9): 1435\u20138.","DOI":"10.1091\/mbc.e09-07-0600"},{"issue":"43","key":"10.1016\/j.yjmcc.2010.10.008_bb0110","doi-asserted-by":"crossref","first-page":"29735","DOI":"10.1074\/jbc.M109.018036","article-title":"Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response","volume":"284","author":"Doroudgar","year":"2009","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.yjmcc.2010.10.008_bb0115","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/01.RES.0000220643.65941.8d","article-title":"Endoplasmic reticulum stress gene induction and protection from ischemia\/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6","volume":"98","author":"Martindale","year":"2006","journal-title":"Circ Res"},{"issue":"20","key":"10.1016\/j.yjmcc.2010.10.008_bb0120","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1074\/jbc.M709776200","article-title":"Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene","volume":"283","author":"Belmont","year":"2008","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.yjmcc.2010.10.008_bb0125","first-page":"1931","article-title":"A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas","volume":"12","author":"Shridhar","year":"1996","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.yjmcc.2010.10.008_bb0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1385\/JMN:20:2:173","article-title":"MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons","volume":"20","author":"Petrova","year":"2003","journal-title":"J Mol Neurosci"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.10.008_bb0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/protein\/gzn080","article-title":"The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional","volume":"22","author":"Parkash","year":"2009","journal-title":"Protein Eng Des Sel"},{"issue":"13","key":"10.1016\/j.yjmcc.2010.10.008_bb0140","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.yexcr.2008.05.001","article-title":"Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death","volume":"314","author":"Apostolou","year":"2008","journal-title":"Exp Cell Res"},{"issue":"7149","key":"10.1016\/j.yjmcc.2010.10.008_bb0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature05957","article-title":"Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo","volume":"448","author":"Lindholm","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2010.10.008_bb0150","doi-asserted-by":"crossref","unstructured":"Lindholm P., Saarma M. Novel CDNF\/MANF family of neurotrophic factors. Dev Neurobiol, 2010 Apr; 70(5): 360\u201371.","DOI":"10.1002\/dneu.20760"},{"issue":"5932","key":"10.1016\/j.yjmcc.2010.10.008_bb0155","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1170653","article-title":"Disulfide formation in the ER and mitochondria: two solutions to a common process","volume":"324","author":"Riemer","year":"2009","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yjmcc.2010.10.008_bb0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbamcr.2007.12.011","article-title":"Ero1 and redox homeostasis in the endoplasmic reticulum","volume":"1783","author":"Sevier","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.10.008_bb0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1247\/csf.07001","article-title":"ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element","volume":"32","author":"Mizobuchi","year":"2007","journal-title":"Cell Struct Funct"},{"issue":"11","key":"10.1016\/j.yjmcc.2010.10.008_bb0170","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCRESAHA.108.180679","article-title":"Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart","volume":"103","author":"Tadimalla","year":"2008","journal-title":"Circ Res"},{"issue":"17","key":"10.1016\/j.yjmcc.2010.10.008_bb0175","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1158\/0008-5472.CAN-04-1606","article-title":"XBP1 is essential for survival under hypoxic conditions and is required for tumor growth","volume":"64","author":"Romero-Ramirez","year":"2004","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.yjmcc.2010.10.008_bb0180","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.mcn.2008.07.016","article-title":"MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain","volume":"39","author":"Lindholm","year":"2008","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.10.008_bb0185","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/cne.22039","article-title":"Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats","volume":"515","author":"Airavaara","year":"2009","journal-title":"J Comp Neurol"},{"issue":"30","key":"10.1016\/j.yjmcc.2010.10.008_bb0190","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.1523\/JNEUROSCI.0833-09.2009","article-title":"Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease","volume":"29","author":"Voutilainen","year":"2009","journal-title":"J Neurosci"},{"issue":"23","key":"10.1016\/j.yjmcc.2010.10.008_bb0195","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1016\/j.febslet.2009.10.053","article-title":"The KDEL receptor: new functions for an old protein","volume":"583","author":"Capitani","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.yjmcc.2010.10.008_bb0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.biochem.76.061705.130002","article-title":"Unsolved mysteries in membrane traffic","volume":"76","author":"Pfeffer","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"6","key":"10.1016\/j.yjmcc.2010.10.008_bb0205","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1083\/jcb.200705180","article-title":"A molecular specificity code for the three mammalian KDEL receptors","volume":"179","author":"Raykhel","year":"2007","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.yjmcc.2010.10.008_bb0210","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/bbrc.1997.7607","article-title":"KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells","volume":"240","author":"Llewellyn","year":"1997","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282810003871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282810003871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T19:16:46Z","timestamp":1559762206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282810003871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0022282810003871"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2010.10.008","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}