{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:26Z","timestamp":1790429606638,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.yjmcc.2011.08.028","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T03:16:19Z","timestamp":1315365379000},"page":"857-864","source":"Crossref","is-referenced-by-count":149,"title":["The coronary circulation and blood flow in left ventricular hypertrophy"],"prefix":"10.1016","volume":"52","author":[{"given":"Paolo G.","family":"Camici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella E.","family":"Rimoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2011.08.028_bb0005","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/hrt.51.6.637","article-title":"Left ventricular hypertrophy. Relation of structure to diastolic function in hypertension","volume":"51","author":"Shapiro","year":"1984","journal-title":"Br Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00001573-200007000-00010","article-title":"Fibrosis and hypertensive heart disease","volume":"15","author":"Weber","year":"2000","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-physiol-012110-142230","article-title":"Myocardial remodeling: cellular and extracellular events and targets","volume":"73","author":"Dixon","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jacc.2009.07.059","article-title":"The hypertensive heart. An integrated understanding informed by imaging","volume":"55","author":"Raman","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0025","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/oxfordjournals.eurheartj.a015090","article-title":"Coronary vasodilator reserve in primary and secondary left ventricular hypertrophy. A study with positron emission tomography","volume":"18","author":"Choudhury","year":"1997","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0035","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0735-1097(91)90869-B","article-title":"Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron emission tomography","volume":"17","author":"Camici","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0040","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa025050","article-title":"Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy","volume":"349","author":"Cecchi","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/3540528806_4","article-title":"Endothelial and neuro-humoral control of coronary blood flow in health and disease","volume":"116","author":"Bassenge","year":"1990","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0050","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/sj.bjp.0707673","article-title":"Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents","volume":"153","author":"Heusch","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0055","first-page":"75","article-title":"Myocardial blood flow measurement by PET: technical aspects and clinical applications","volume":"46","author":"Kaufmann","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0008-6363(01)00202-4","article-title":"Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans","volume":"50","author":"Chareonthaitawee","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-009-0074-7","article-title":"Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve","volume":"105","author":"Heusch","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0070","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1056\/NEJM199406233302503","article-title":"Relation between myocardial blood flow and the severity of coronary-artery stenosis","volume":"330","author":"Uren","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0075","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1161\/01.CIR.99.16.2090","article-title":"Augmented alpha-adrenergic constriction of atherosclerotic human coronary arteries","volume":"99","author":"Baumgart","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0080","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2967\/jnumed.108.054478","article-title":"The clinical value of myocardial blood flow measurement","volume":"50","author":"Camici","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0085","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0735-1097(89)90105-8","article-title":"Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography","volume":"14","author":"Bergmann","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0090","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/01.CIR.83.3.875","article-title":"Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography","volume":"83","author":"Araujo","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1161\/01.CIR.78.1.104","article-title":"Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect","volume":"78","author":"Iida","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0100","first-page":"1848","article-title":"Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET","volume":"40","author":"Kaufmann","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0105","first-page":"146","article-title":"Bicycle exercise stress in PET for assessment of coronary flow reserve: repeatability and comparison with adenosine stress","volume":"44","author":"Wyss","year":"2003","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0002-9149(79)80006-5","article-title":"Regional myocardial perfusion assessed with N-13 labeled ammonia and positron emission computerized axial tomography","volume":"43","author":"Schelbert","year":"1979","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0115","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/0735-1097(90)90237-J","article-title":"Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging","volume":"15","author":"Hutchins","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0120","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/01.CIR.80.5.1328","article-title":"13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography","volume":"80","author":"Krivokapich","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0125","first-page":"83","article-title":"Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET","volume":"34","author":"Muzik","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0130","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/01.CIR.82.4.1377","article-title":"Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model","volume":"82","author":"Herrero","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0135","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.2967\/jnumed.104.007831","article-title":"Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET","volume":"50","author":"El Fakhri","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0140","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1161\/01.CIR.89.5.2290","article-title":"Enhancement of regional myocardial efficiency and persistence of perfusion, oxidative, and functional reserve with paired pacing of stunned myocardium","volume":"89","author":"Bergmann","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0145","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s002590050279","article-title":"Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols","volume":"25","author":"Hermansen","year":"1998","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0150","first-page":"616","article-title":"Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems","volume":"26","author":"Huang","year":"1985","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0155","first-page":"1626","article-title":"Reproducibility of measurement of regional resting and hyperemic myocardial blood flow assessed with PET","volume":"37","author":"Nagamachi","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0160","first-page":"212","article-title":"Assessment of the long-term reproducibility of baseline and dobutamine-induced myocardial blood flow in patients with stable coronary artery disease","volume":"46","author":"Jagathesan","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0165","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy: a systematic review","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0170","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0735-1097(03)00941-0","volume":"42","author":"Maron","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0175","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMra0902923","article-title":"Inherited cardiomyopathies","volume":"364","author":"Watkins","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0180","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrcardio.2009.9","article-title":"Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis","volume":"6","author":"Olivotto","year":"2009","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0185","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0190","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0735-1097(01)01765-X","article-title":"Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction","volume":"39","author":"Jenni","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl.","key":"10.1016\/j.yjmcc.2011.08.028_bb0195","first-page":"151","article-title":"Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy","volume":"57","author":"Neglia","year":"2005","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0200","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/hrt.2004.054015","article-title":"Coronary microvascular dysfunction in male patients with Anderson\u2013Fabry disease and the effect of treatment with alpha galactosidase A","volume":"92","author":"Elliott","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0205","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.106.657023","article-title":"Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging","volume":"115","author":"Petersen","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0210","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0025-6196(11)60890-2","article-title":"Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy","volume":"83","author":"Olivotto","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0215","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12265-009-9137-2","article-title":"The many faces of hypertrophic cardiomyopathy: from developmental biology to clinical practice","volume":"2","author":"Olivotto","year":"2009","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0220","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0735-1097(86)80181-4","article-title":"Intramural (\u201csmall vessel\u201d) coronary artery disease in hypertrophic cardiomyopathy","volume":"8","author":"Maron","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0225","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/hupa.2000.16659","article-title":"Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia","volume":"31","author":"Basso","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0230","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.CIR.97.3.230","article-title":"Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation","volume":"97","author":"Krams","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0235","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0735-1097(98)00036-9","article-title":"Alterations of the architecture of subendocardial arterioles in patients with hypertrophic cardiomyopathy and impaired coronary vasodilator reserve: a possible cause for myocardial ischemia","volume":"31","author":"Schwartzkopff","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0240","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1161\/01.CIR.83.5.1660","article-title":"Myocardial metabolic, hemodynamic, and electrocardiographic significance of reversible thallium-201 abnormalities in hypertrophic cardiomyopathy","volume":"83","author":"Cannon","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0245","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0735-1097(03)00189-X","article-title":"Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance","volume":"41","author":"Moon","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0250","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.105.583500","article-title":"Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy","volume":"114","author":"Harris","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0255","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jacc.2009.04.072","article-title":"The case for myocardial ischemia in hypertrophic cardiomyopathy","volume":"54","author":"Maron","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0260","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0735-1097(87)80159-6","article-title":"Differences in coronary flow and myocardial metabolism at rest and during pacing between patients with obstructive and patients with nonobstructive hypertrophic cardiomyopathy","volume":"10","author":"Cannon","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0265","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9149(94)90404-9","article-title":"Effect of verapamil on absolute myocardial blood flow in hypertrophic cardiomyopathy","volume":"74","author":"Gistri","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0270","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.amjcard.2007.12.032","article-title":"Effect of successful alcohol septal ablation on microvascular function in patients with obstructive hypertrophic cardiomyopathy","volume":"101","author":"Soliman","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0275","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtcvs.2003.11.003","article-title":"Regional myocardial ischemia in hypertrophic cardiomyopathy: impact of myectomy","volume":"128","author":"Jorg-Ciopor","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0280","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.jacc.2004.03.035","article-title":"The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy","volume":"43","author":"Moon","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0285","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/S0735-1097(02)02602-5","article-title":"Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy","volume":"40","author":"Choudhury","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0290","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCHEARTFAILURE.108.768119","article-title":"Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy","volume":"1","author":"Maron","year":"2008","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0295","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2967\/jnumed.107.050138","article-title":"Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy","volume":"49","author":"Sotgia","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0300","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.nuclcard.2006.05.018","article-title":"Regional heterogeneity of resting perfusion in hypertrophic cardiomyopathy is related to delayed contrast enhancement but not to systolic function: a PET and MRI study","volume":"13","author":"Knaapen","year":"2006","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0305","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jacc.2011.05.018","article-title":"Microvascular function is selectively impaired in hypertrophic cardiomyopathy patients with sarcomere myofilament gene mutations","volume":"58","author":"Olivotto I","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0310","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2005.10.050","article-title":"Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy","volume":"47","author":"Olivotto","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0315","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jacc.2010.05.010","article-title":"Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"56","author":"O'Hanlon","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0320","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-146-6-200703200-00007","article-title":"Narrative review: Fabry disease","volume":"146","author":"Clarke","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0325","first-page":"38","article-title":"Cardiac abnormalities in Anderson\u2013Fabry disease and Fabry's cardiomyopathy","volume":"22","author":"Morrissey","year":"2011","journal-title":"Cardiovasc J Afr"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0330","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7326\/0003-4819-130-1-199901050-00005","article-title":"Physiologic left ventricular cavity dilatation in elite athletes","volume":"130","author":"Pelliccia","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0335","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/hc0802.104534","article-title":"Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning","volume":"105","author":"Pelliccia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0340","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1148\/radiol.2511081118","article-title":"Myocardial late gadolinium enhancement: prevalence, pattern, and prognostic relevance in marathon runners","volume":"251","author":"Breuckmann","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0345","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10554-008-9337-x","article-title":"Left ventricular volumes and mass in marathon runners and their association with cardiovascular risk factors","volume":"25","author":"Nassenstein","year":"2009","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0350","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0002-9149(97)00778-9","article-title":"Comparison of coronary vasodilator reserve in elite rowing athletes versus hypertrophic cardiomyopathy","volume":"80","author":"Radvan","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0355","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1152\/jappl.1998.85.3.1160","article-title":"Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart","volume":"85","author":"White","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0360","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10741-008-9125-7","article-title":"Cardiac hypertrophy and thyroid hormone signaling","volume":"15","author":"Dillmann","year":"2010","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0365","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.vph.2009.10.007","article-title":"Thyroid hormone and angiogenesis","volume":"52","author":"Luidens","year":"2010","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0370","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.CIR.75.6.1130","article-title":"Quantitative analysis of narrowings of intramyocardial small arteries in normal hearts, hypertensive hearts, and hearts with hypertrophic cardiomyopathy","volume":"75","author":"Tanaka","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0375","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.CIR.86.1.38","article-title":"Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy","volume":"86","author":"Rakusan","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0380","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0895-7061(00)01212-7","article-title":"Coronary microvasculature alteration in hypertensive rats. Effect of treatment with a diuretic and an ACE inhibitor","volume":"14","author":"Levy","year":"2001","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0385","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0735-1097(90)90620-5","article-title":"Response of the coronary vasculature to myocardial hypertrophy","volume":"15","author":"Tomanek","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0390","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0735-1097(00)00594-5","article-title":"Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy","volume":"35","author":"Hamasaki","year":"2000","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl. D","key":"10.1016\/j.yjmcc.2011.08.028_bb0395","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/13.suppl_D.17","article-title":"Morphometric investigation of human myocardium in arterial hypertension and valvular aortic stenosis","volume":"13","author":"Schwartzkopff","year":"1992","journal-title":"Eur Heart J"},{"issue":"Suppl. I","key":"10.1016\/j.yjmcc.2011.08.028_bb0400","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/eurheartj\/16.suppl_I.82","article-title":"Remodelling of intramyocardial arterioles and extracellular matrix in patients with arterial hypertension and impaired coronary reserve","volume":"16","author":"Schwartzkopff","year":"1995","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0405","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0895-7061(02)02985-0","article-title":"Positron emission tomography, echo-doppler, and exercise studies of functional capacity in hypertensive heart disease","volume":"15","author":"Akinboboye","year":"2002","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0410","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/HJH.0b013e328340a08e","article-title":"Perindopril and indapamide reverse coronary microvascular remodelling and improve flow in arterial hypertension","volume":"29","author":"Neglia","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0415","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.jhh.1001716","article-title":"Association between vascular dysfunction and reduced myocardial flow reserve in patients with hypertension: a LIFE substudy","volume":"18","author":"Olsen","year":"2004","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0420","first-page":"419","article-title":"PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography","volume":"45","author":"Schindler","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0425","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/0895-7061(95)00028-N","article-title":"Impairment of flow-dependent coronary dilation in hypertensive patients. Demonstration by cold pressor test induced flow velocity increase","volume":"8","author":"Nitenberg","year":"1995","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0430","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jacc.2007.06.013","article-title":"Olmesartan, but not amlodipine, improves endothelium-dependent coronary dilation in hypertensive patients","volume":"50","author":"Naya","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0435","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.HYP.0000141273.72768.b7","article-title":"Myocardial perfusion during long-term angiotensin-converting enzyme inhibition or {beta}-blockade in patients with essential hypertension","volume":"44","author":"Buus","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0440","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.HYP.36.2.220","article-title":"Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease","volume":"36","author":"Schwartzkopff","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0445","series-title":"Physiology and pathophysiology of the heart","first-page":"1109","article-title":"Extravascular coronary resistance","author":"Downey","year":"1995"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0450","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/hc0402.102931","article-title":"Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries","volume":"105","author":"Rajappan","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0455","doi-asserted-by":"crossref","first-page":"194S","DOI":"10.1016\/S0895-7061(01)02088-X","article-title":"Fibrosis and ischemia: the real risks in hypertensive heart disease","volume":"14","author":"Frohlich","year":"2001","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0460","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJM198811173192002","article-title":"Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy","volume":"319","author":"Brush","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0465","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/hc0202.102119","article-title":"Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction","volume":"105","author":"Neglia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0470","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/CIRCHEARTFAILURE.110.958199","article-title":"Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure","volume":"4","author":"Zile","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0475","first-page":"230","article-title":"Guidelines on the management of valvular heart disease: the task force on the management of valvular heart disease of the European society of cardiology","volume":"28","author":"Vahanian","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0480","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.109.894170","article-title":"Natural history of very severe aortic stenosis","volume":"121","author":"Rosenhek","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0485","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/hrt.2005.062422","article-title":"Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: a transthoracic Doppler and myocardial contrast echocardiography study","volume":"92","author":"Galiuto","year":"2006","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.yjmcc.2011.08.028_bb0490","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/eurheartj\/ehr084","article-title":"Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis","volume":"32","author":"Ng","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0495","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJMcp010846","article-title":"Clinical practice. Aortic stenosis","volume":"346","author":"Carabello","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0500","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1152\/japplphysiol.00049.2008","article-title":"Impairment of coronary flow reserve in aortic stenosis","volume":"106","author":"Garcia","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0505","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/01.CIR.0000074211.28917.31","article-title":"Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis","volume":"107","author":"Rajappan","year":"2003","journal-title":"Circulation"},{"issue":"9 Suppl","key":"10.1016\/j.yjmcc.2011.08.028_bb0510","first-page":"I429","article-title":"Physiologic compensation is supranormal in compensated aortic stenosis: does it return to normal after aortic valve replacement or is it blunted by coexistent coronary artery disease?: an intramyocardial magnetic resonance imaging study","volume":"112","author":"Biederman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0515","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1136\/hrt.2007.135475","article-title":"Myocardial blood flow in patients with low-flow, low-gradient aortic stenosis: differences between true and pseudo-severe aortic stenosis. Results from the multicentre TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study","volume":"94","author":"Burwash","year":"2008","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2011.08.028_bb0520","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/01.CIR.92.4.978","article-title":"Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy","volume":"92","author":"Hittinger","year":"1995","journal-title":"Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282811003750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282811003750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T01:40:03Z","timestamp":1560562803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282811003750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":104,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0022282811003750"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2011.08.028","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}