{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:06:35Z","timestamp":1770987995801,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.yjmcc.2012.07.010","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T14:48:38Z","timestamp":1343746118000},"page":"487-496","source":"Crossref","is-referenced-by-count":88,"title":["Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells"],"prefix":"10.1016","volume":"53","author":[{"given":"Donghong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yequn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xina","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2012.07.010_bb0005","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1056\/NEJM199502023320502","article-title":"Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis","volume":"332","author":"Selhub","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nm0496-386","article-title":"Homocysteine and vascular disease","volume":"2","author":"McCully","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jvs.2004.12.043","article-title":"Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells","volume":"41","author":"Akasaka","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cardiores.2005.08.016","article-title":"Hyperhomocysteinemia inhibits post-injury reendothelialization in mice","volume":"69","author":"Tan","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbapap.2008.10.001","article-title":"Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells","volume":"1794","author":"Liu","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0030","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1523-1755.2004.00795.x","article-title":"Activation of mesangial cell MAPK in response to homocysteine","volume":"66","author":"Ingram","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0035","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood-2007-06-096701","article-title":"Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene","volume":"110","author":"Jamaluddin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0040","doi-asserted-by":"crossref","first-page":"C1466","DOI":"10.1152\/ajpcell.00304.2009","article-title":"Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin","volume":"297","author":"Jiang","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-5-1","article-title":"Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies","volume":"5","author":"Sharma","year":"2006","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0050","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJM198806093182303","article-title":"Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma","volume":"318","author":"Libby","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0055","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1073\/pnas.85.5.1524","article-title":"Expression and developmental control of platelet-derived growth factor A-chain and B-chain\/Sis genes in rat aortic smooth muscle cells","volume":"85","author":"Majesky","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cytogfr.2004.03.004","article-title":"PDGF and cardiovascular disease","volume":"15","author":"Raines","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0065","doi-asserted-by":"crossref","first-page":"17334","DOI":"10.1016\/S0021-9258(19)85339-5","article-title":"Site-specific methylation inhibits transcriptional activity of platelet-derived growth factor A-chain promoter","volume":"268","author":"Lin","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccr.2006.11.023","article-title":"High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene","volume":"11","author":"Bruna","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0075","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1158\/1078-0432.CCR-08-2062","article-title":"Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation","volume":"15","author":"Hervouet","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0080","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.ATV.18.3.473","article-title":"LDL induces transcription factor activator protein-1 in human endothelial cells","volume":"18","author":"Zhu","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0085","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/01.ATV.0000020550.65963.E9","article-title":"NO attenuates insulin signaling and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B-mediated mechanism","volume":"22","author":"Sreejayan","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0090","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/cvr\/cvm105","article-title":"Ageing-exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells","volume":"77","author":"Wu","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0095","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bbagrm.2010.09.006","article-title":"DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism","volume":"1799","author":"Zhang","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0100","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/nar\/gkm923","article-title":"Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation","volume":"36","author":"Sanchez-Guerrero","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0105","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood-2005-06-2377","article-title":"Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1","volume":"107","author":"Liu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0110","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1158\/0008-5472.CAN-04-0989","article-title":"Hepatocyte growth factor\/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma","volume":"65","author":"Worden","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0115","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCRESAHA.111.259325","article-title":"Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo","volume":"110","author":"Zhang","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.CIR.103.1.133","article-title":"Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury","volume":"103","author":"Morita","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0125","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1161\/ATVBAHA.107.148544","article-title":"Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells","volume":"27","author":"Jiang","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/jsre.2001.6304","article-title":"Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries","volume":"102","author":"Chen","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0135","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1139\/y00-016","article-title":"Short-term exposure to homocysteine depresses rat aortic contractility by an endothelium-dependent mechanism","volume":"78","author":"Wang","year":"2000","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0140","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1111\/j.1742-4658.2005.04989.x","article-title":"Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family","volume":"272","author":"Reigstad","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0145","doi-asserted-by":"crossref","first-page":"27679","DOI":"10.1074\/jbc.270.46.27679","article-title":"Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells","volume":"270","author":"Khachigian","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0150","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.271.5254.1427","article-title":"Egr-1-induced endothelial gene expression: a common theme in vascular injury","volume":"271","author":"Khachigian","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0155","doi-asserted-by":"crossref","first-page":"40289","DOI":"10.1074\/jbc.M406063200","article-title":"Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1","volume":"279","author":"Midgley","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/01.RES.0000141135.36279.67","article-title":"Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1","volume":"95","author":"Santiago","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0165","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.yjmcc.2011.06.023","article-title":"Platelet-derived growth factor involvement in myocardial remodeling following infarction","volume":"51","author":"Zhao","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0170","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/ATVBAHA.108.178558","article-title":"PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts","volume":"29","author":"Tuuminen","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0175","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1038\/ki.1997.501","article-title":"Dipyridamole inhibits PDGF- and bFGF-induced vascular smooth muscle cell proliferation","volume":"52","author":"Himmelfarb","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0180","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCRESAHA.109.206029","article-title":"TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner","volume":"106","author":"Chan","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Goll","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0190","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1074\/jbc.M109.064956","article-title":"DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta","volume":"285","author":"Novakovic","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0195","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/cvr\/cvr009","article-title":"Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats","volume":"90","author":"Lim","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/cvr\/cvp182","article-title":"Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE\u2212\/\u2212 mice","volume":"84","author":"Feng","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0205","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1160\/TH09-06-0393","article-title":"Homocysteine and arterial thrombosis: challenge and opportunity","volume":"103","author":"Di Minno","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.yjmcc.2012.07.010_bb0210","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1538-7836.2005.01708.x","article-title":"Activation of p38 MAPKinase\/cPLA2 pathway in homocysteine-treated platelets","volume":"4","author":"Leoncini","year":"2006","journal-title":"J Thromb Haemost"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282812002581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282812002581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T23:28:52Z","timestamp":1643066932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282812002581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0022282812002581"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2012.07.010","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}