{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:32:48Z","timestamp":1789169568360,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KR 1187\/5-4"],"award-info":[{"award-number":["KR 1187\/5-4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["1187\/19-1"],"award-info":[{"award-number":["1187\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["241577"],"award-info":[{"award-number":["241577"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands organization for scientific research (NWO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.yjmcc.2013.01.001","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T23:38:39Z","timestamp":1357947519000},"page":"13-22","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes"],"prefix":"10.1016","volume":"57","author":[{"given":"Theresia","family":"Kraft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Rosalie","family":"Witjas-Paalberends","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky M.","family":"Boontje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almuth","family":"Brandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Montag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Hodgkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Francino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Navarro-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger J.M.","family":"Stienen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2013.01.001_bb0005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0010","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0195-668X(03)00479-2","volume":"24","author":"Maron","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0015","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.CIR.0000066323.15244.54","article-title":"Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy","volume":"107","author":"Richard","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1152\/physrev.1996.76.2.371","article-title":"Molecular diversity of myofibrillar proteins: gene regulation and functional significance","volume":"76","author":"Schiaffino","year":"1996","journal-title":"Physiol Rev"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0025","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1172\/JCI116530","article-title":"Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy","volume":"91","author":"Cuda","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0030","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.1021\/ac701711h","article-title":"Quantification of mutant versus wild-type myosin in human muscle biopsies using nano-LC\/ESI\u2013MS","volume":"79","author":"Becker","year":"2007","journal-title":"Anal Chem"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1018613907574","article-title":"The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy","volume":"18","author":"Cuda","year":"1997","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/cvr\/cvn094","article-title":"The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy","volume":"79","author":"Jacques","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.yjmcc.2010.06.006","article-title":"Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy","volume":"49","author":"Hoskins","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0050","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1113\/jphysiol.2008.155952","article-title":"The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils","volume":"586","author":"Belus","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0055","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1006\/jmcc.2000.1260","article-title":"Malignant hypertrophic cardiomyopathy caused by the Arg723Gly mutation in beta-myosin heavy chain gene","volume":"32","author":"Enjuto","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0060","doi-asserted-by":"crossref","first-page":"H1242","DOI":"10.1152\/ajpheart.00686.2004","article-title":"Hypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells","volume":"288","author":"Kirschner","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bpj.2009.05.023","article-title":"Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance","volume":"97","author":"Seebohm","year":"2009","journal-title":"Biophys J"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0070","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/01.CIR.96.5.1495","article-title":"Troponin I phosphorylation in the normal and failing adult human heart","volume":"96","author":"Bodor","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yjmcc.2007.05.003","article-title":"Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure","volume":"43","author":"El-Armouche","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0080","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1161\/CIRCRESAHA.108.193326","article-title":"Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium","volume":"104","author":"Borbely","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0085","first-page":"518","article-title":"The left and right ventricle of a patient with a R723G mutation of the beta-myosin heavy chain and severe hypertrophic cardiomyopathy show no differences in the expression of myosin mRNA","volume":"17","author":"Borchert","year":"2010","journal-title":"Cardiol J"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0090","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10974-010-9231-8","article-title":"More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease","volume":"31","author":"Hamdani","year":"2010","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0008-6363(02)00606-5","article-title":"Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins","volume":"57","author":"van der Velden","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0100","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1073\/pnas.83.10.3542","article-title":"Rate of force generation in muscle: correlation with actomyosin ATPase activity in solution","volume":"83","author":"Brenner","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0105","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00395-011-0205-9","article-title":"Unequal allelic expression of wild-type and mutated beta-myosin in familial hypertrophic cardiomyopathy","volume":"106","author":"Tripathi","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0110","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/prca.200600891","article-title":"Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies","volume":"1","author":"Zaremba","year":"2007","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0115","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1161\/CIRCULATIONAHA.105.587519","article-title":"Myocardial structure and function differ in systolic and diastolic heart failure","volume":"113","author":"van Heerebeek","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0008-6363(02)00662-4","article-title":"The effect of myosin light chain 2 dephosphorylation on Ca2+-sensitivity of force is enhanced in failing human hearts","volume":"57","author":"van der Velden","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0125","doi-asserted-by":"crossref","first-page":"40710","DOI":"10.1074\/jbc.M203446200","article-title":"Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy","volume":"277","author":"Robinson","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0130","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCRESAHA.107.156380","article-title":"Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments","volume":"101","author":"Robinson","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/CIRCHEARTFAILURE.111.963702","article-title":"Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function","volume":"5","author":"van Dijk","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0140","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1073\/pnas.85.9.3265","article-title":"Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction","volume":"85","author":"Brenner","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0145","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/hc3501.095485","article-title":"Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts","volume":"104","author":"van der Velden","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0150","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1073\/pnas.062415899","article-title":"Mutation of the myosin converter domain alters cross-bridge elasticity","volume":"99","author":"K\u00f6hler","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.137.1.131","volume":"137","author":"Becker","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0160","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bpj.2009.11.005","article-title":"Microarchitecture is severely compromised but motor protein function is preserved in dystrophic mdx skeletal muscle","volume":"98","author":"Friedrich","year":"2010","journal-title":"Biophys J"},{"key":"10.1016\/j.yjmcc.2013.01.001_bb0165","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/01.RES.0000021115.24712.99","article-title":"Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes","volume":"90","author":"Yamasaki","year":"2002","journal-title":"Circ Res"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282813000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282813000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:24:38Z","timestamp":1588836278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282813000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":33,"alternative-id":["S0022282813000047"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2013.01.001","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}