{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:09:13Z","timestamp":1793138953066,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.yjmcc.2013.03.010","type":"journal-article","created":{"date-parts":[[2013,3,24]],"date-time":"2013-03-24T13:17:04Z","timestamp":1364131024000},"page":"50-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves"],"prefix":"10.1016","volume":"60","author":[{"given":"Loren E.","family":"Dupuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Osinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2013.03.010_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0010","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/ajmg.a.33974","article-title":"Risk factors for aortic valve disease in bicuspid aortic valve: a family-based study","volume":"155A","author":"Calloway","year":"2011","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000079779","article-title":"The epidemiology of valvular heart diseases: the problem is growing","volume":"41","author":"Supino","year":"2004","journal-title":"Adv Cardiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0020","doi-asserted-by":"crossref","first-page":"196037","DOI":"10.1155\/2012\/196037","article-title":"Bicuspid aortic valve disease: a comprehensive review","volume":"2012","author":"Mordi","year":"2012","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0025","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.athoracsur.2011.09.063","article-title":"Bicuspid pulmonary valve with atrial septal defect leading to pulmonary aneurysm","volume":"93","author":"Goda","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0030","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.jacc.2009.05.027","article-title":"Bicuspid pulmonic valve","volume":"54","author":"Vedanthan","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0035","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","article-title":"Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease\u20142011 update","volume":"124","author":"Rajamannan","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0040","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.jacc.2009.07.044","article-title":"Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities","volume":"54","author":"Fernandez","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0045","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/01.RES.87.10.888","article-title":"Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5","volume":"87","author":"Biben","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0050","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1172\/JCI44555","article-title":"Loss of Gata5 in mice leads to bicuspid aortic valve","volume":"121","author":"Laforest","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0055","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/01.CIR.101.20.2345","article-title":"Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase","volume":"101","author":"Lee","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/hmg\/ddr434","article-title":"Cardiovascular defects in a mouse model of HOXA1 syndrome","volume":"21","author":"Makki","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0065","doi-asserted-by":"crossref","first-page":"e35539","DOI":"10.1371\/journal.pone.0035539","article-title":"Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development","volume":"7","author":"Thomas","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0070","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","article-title":"Mutations in NOTCH1 cause aortic valve disease","volume":"437","author":"Garg","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0075","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.bbrc.2006.05.046","article-title":"Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve","volume":"345","author":"Mohamed","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0080","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jtcvs.2007.02.041","article-title":"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms","volume":"134","author":"McKellar","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0085","doi-asserted-by":"crossref","first-page":"e27743","DOI":"10.1371\/journal.pone.0027743","article-title":"Inhibitory role of Notch1 in calcific aortic valve disease","volume":"6","author":"Acharya","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0095","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/hmg\/6.7.1021","article-title":"Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis","volume":"6","author":"Li","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0100","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0105","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/dvdy.21725","article-title":"Origin and fate of cardiac mesenchyme","volume":"237","author":"Snarr","year":"2008","journal-title":"Dev Dyn"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0110","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1172\/JCI200422715","article-title":"TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome","volume":"114","author":"Ng","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ydbio.2007.02.002","article-title":"Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development","volume":"305","author":"Lincoln","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ydbio.2006.03.027","article-title":"Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development","volume":"294","author":"Lincoln","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0125","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCRESAHA.108.177238","article-title":"Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo","volume":"103","author":"Levay","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0130","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00246-009-9616-x","article-title":"Transcriptional regulation of heart valve progenitor cells","volume":"31","author":"Chakraborty","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ydbio.2010.08.021","article-title":"Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves","volume":"347","author":"Chakraborty","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ydbio.2011.06.041","article-title":"Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease","volume":"357","author":"Dupuis","year":"2011","journal-title":"Dev Biol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0145","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.modgep.2005.03.004","article-title":"Adamts9 is widely expressed during mouse embryo development","volume":"5","author":"Jungers","year":"2005","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0150","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.devcel.2009.09.008","article-title":"ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression","volume":"17","author":"McCulloch","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0155","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/dvdy.21059","article-title":"Versican proteolysis mediates myocardial regression during outflow tract development","volume":"236","author":"Kern","year":"2007","journal-title":"Dev Dyn"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0160","first-page":"H1595","article-title":"A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice","volume":"273","author":"Fewell","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0165","first-page":"352","article-title":"Bilateral semilunar valve disease in a child with partial deletion of the Williams\u2013Beuren syndrome region is associated with elastin haploinsufficiency","volume":"15","author":"Hinton","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0170","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.110.221358","article-title":"Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model","volume":"107","author":"Hinton","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/bj2190451","article-title":"Collagen composition of normal and myxomatous human mitral heart valves","volume":"219","author":"Cole","year":"1984","journal-title":"Biochem J"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCULATIONAHA.106.622621","article-title":"Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy","volume":"115","author":"Kyndt","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0185","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.108.843516","article-title":"Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms","volume":"120","author":"Pilop","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0190","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/ng.2007.6","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections","volume":"39","author":"Guo","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0195","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","article-title":"Role of endothelial\u2013mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders","volume":"179","author":"Piera-Velazquez","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0200","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","article-title":"Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation","volume":"106","author":"Leask","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0205","doi-asserted-by":"crossref","first-page":"17871","DOI":"10.1074\/jbc.M008422200","article-title":"Filamin associates with Smads and regulates transforming growth factor-beta signaling","volume":"276","author":"Sasaki","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0210","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.RES.0000040397.23817.E5","article-title":"Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression","volume":"91","author":"Saura","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5551\/jat.8185","article-title":"Activation of TGF-beta receptors and Smad proteins by atorvastatin is related to reduced atherogenesis in ApoE\/LDLR double knockout mice","volume":"19","author":"Vecerova","year":"2012","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0220","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.athoracsur.2006.11.086","article-title":"Endothelial nitric oxide synthase in bicuspid aortic valve disease","volume":"83","author":"Aicher","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0225","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/dvdy.20838","article-title":"Proteolytic cleavage of versican during cardiac cushion morphogenesis","volume":"235","author":"Kern","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0230","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1050-1738(00)00023-2","article-title":"A novel role for cardiac neural crest in heart development","volume":"9","author":"Farrell","year":"1999","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0235","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/heart.89.9.1110","article-title":"Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks","volume":"89","author":"Anderson","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0240","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1469-7580.2003.00168.x","article-title":"Septation and separation within the outflow tract of the developing heart","volume":"202","author":"Webb","year":"2003","journal-title":"J Anat"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0245","doi-asserted-by":"crossref","first-page":"21114","DOI":"10.1074\/jbc.M109.096479","article-title":"Versican facilitates chondrocyte differentiation and regulates joint morphogenesis","volume":"285","author":"Choocheep","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0250","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/sj.cr.7290318","article-title":"The interaction of versican with its binding partners","volume":"15","author":"Wu","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0255","doi-asserted-by":"crossref","first-page":"26016","DOI":"10.1074\/jbc.M110.208694","article-title":"Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1) signaling","volume":"286","author":"Velasco","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0260","doi-asserted-by":"crossref","first-page":"34298","DOI":"10.1074\/jbc.M111.254938","article-title":"Pericellular versican regulates the fibrobl\u2013myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis","volume":"286","author":"Hattori","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0265","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1100\/tsw.2011.132","article-title":"The inter-relationship of periostin, TGF beta, and BMP in heart valve development and valvular heart diseases","volume":"11","author":"Conway","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0270","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/dvdy.22702","article-title":"Transforming growth factor Beta2 is required for valve remodeling during heart development","volume":"240","author":"Azhar","year":"2011","journal-title":"Dev Dyn"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0275","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/j.jacc.2009.12.068","article-title":"Bicuspid aortic valve disease","volume":"55","author":"Siu","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0280","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.carpath.2011.01.002","article-title":"Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix","volume":"21","author":"Stephens","year":"2012","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0285","doi-asserted-by":"crossref","first-page":"e26769","DOI":"10.1371\/journal.pone.0026769","article-title":"Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes","volume":"6","author":"Peacock","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0290","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCRESAHA.109.213702","article-title":"Reduced sox9 function promotes heart valve calcification phenotypes in vivo","volume":"106","author":"Peacock","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0295","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1152\/japplphysiol.00408.2004","article-title":"Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries","volume":"98","author":"Woodman","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.yjmcc.2013.03.010_bb0300","first-page":"1444","article-title":"Effects of rat urotensin II on coronary flow and myocardial eNOS protein expression in isolated rat heart","volume":"25","author":"Li","year":"2004","journal-title":"Acta Pharmacol Sin"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282813000916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282813000916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T09:05:59Z","timestamp":1562835959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282813000916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":60,"alternative-id":["S0022282813000916"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2013.03.010","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2013.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}